Intrabursal immunization as a possible route to overcome immunosuppression due to maternal antibodies

Vaccination is the most effective mean of preventing, controlling, and even eradicating infectious diseases. Poultry are vaccinated through various routes including eye/nose drops, drinking water, vent brush, or injections. The prolonged suppression effect of maternal antibodies on humoral immune re...

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Autores principales:	Elsayed Mohammed, Mohammed Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	South Valley University 2019
Materias:	chick maternal antibody Agriculture S Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/aec8420fc8954a6482a296589205711a
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spelling	oai:doaj.org-article:aec8420fc8954a6482a296589205711a2021-12-02T12:07:13ZIntrabursal immunization as a possible route to overcome immunosuppression due to maternal antibodiesdoi:10.21608/SVU.2019.17189.10302535-18262535-1877https://doaj.org/article/aec8420fc8954a6482a296589205711a2019-11-01T00:00:00Zhttps://svu.journals.ekb.eg/article_57912.htmlhttps://doaj.org/toc/2535-1826https://doaj.org/toc/2535-1877Vaccination is the most effective mean of preventing, controlling, and even eradicating infectious diseases. Poultry are vaccinated through various routes including eye/nose drops, drinking water, vent brush, or injections. The prolonged suppression effect of maternal antibodies on humoral immune response of newly hatched chicks to active immunization has been reported, while the effect of vaccination route on this suppression still unclear. Laying hens were immunized with dinitrophenyl-keyhole limpet hemocyanin (DNP-KLH). Purified maternal anti-DNP or non-specific IgY antibodies were transferred by yolk sac inoculation to newly hatched chicks (chicks of maternal and no-maternal antibodies), and they were immunized with DNP-KLH via intrabursal route at 0.1, 1 and 10 mg/kg body weight (BW) and with 1 mg/kg BW intraperitoneally at 1 and 4 weeks of age. Concentration of anti-DNP antibodies in serum samples of these chicks was measured by using Enzyme- linked immunosorbent assay (ELISA). The immune response to intrabursal immunization was higher in chicks of no-maternal antibodies than that of chicks of maternal antibodies at 5 weeks of age. Intrabursal immunization showed higher response than intraperitoneal one at the same dose. These results confirmed that the immune suppressive effect of maternal antibodies on the immune response of the newly hatched chicks was antigen specific and depends on the ratio of antigen/maternal antibody at the time of immunization. Furthermore, intrabursal vaccination showed promising results than intraperitoneal vaccination at the same dose. Elsayed MohammedMohammed AhmedSouth Valley Universityarticlechickmaternal antibodyAgricultureSVeterinary medicineSF600-1100ENSVU-International Journal of Veterinary Sciences, Vol 3, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	chick maternal antibody Agriculture S Veterinary medicine SF600-1100
spellingShingle	chick maternal antibody Agriculture S Veterinary medicine SF600-1100 Elsayed Mohammed Mohammed Ahmed Intrabursal immunization as a possible route to overcome immunosuppression due to maternal antibodies
description	Vaccination is the most effective mean of preventing, controlling, and even eradicating infectious diseases. Poultry are vaccinated through various routes including eye/nose drops, drinking water, vent brush, or injections. The prolonged suppression effect of maternal antibodies on humoral immune response of newly hatched chicks to active immunization has been reported, while the effect of vaccination route on this suppression still unclear. Laying hens were immunized with dinitrophenyl-keyhole limpet hemocyanin (DNP-KLH). Purified maternal anti-DNP or non-specific IgY antibodies were transferred by yolk sac inoculation to newly hatched chicks (chicks of maternal and no-maternal antibodies), and they were immunized with DNP-KLH via intrabursal route at 0.1, 1 and 10 mg/kg body weight (BW) and with 1 mg/kg BW intraperitoneally at 1 and 4 weeks of age. Concentration of anti-DNP antibodies in serum samples of these chicks was measured by using Enzyme- linked immunosorbent assay (ELISA). The immune response to intrabursal immunization was higher in chicks of no-maternal antibodies than that of chicks of maternal antibodies at 5 weeks of age. Intrabursal immunization showed higher response than intraperitoneal one at the same dose. These results confirmed that the immune suppressive effect of maternal antibodies on the immune response of the newly hatched chicks was antigen specific and depends on the ratio of antigen/maternal antibody at the time of immunization. Furthermore, intrabursal vaccination showed promising results than intraperitoneal vaccination at the same dose.
format	article
author	Elsayed Mohammed Mohammed Ahmed
author_facet	Elsayed Mohammed Mohammed Ahmed
author_sort	Elsayed Mohammed
title	Intrabursal immunization as a possible route to overcome immunosuppression due to maternal antibodies
title_short	Intrabursal immunization as a possible route to overcome immunosuppression due to maternal antibodies
title_full	Intrabursal immunization as a possible route to overcome immunosuppression due to maternal antibodies
title_fullStr	Intrabursal immunization as a possible route to overcome immunosuppression due to maternal antibodies
title_full_unstemmed	Intrabursal immunization as a possible route to overcome immunosuppression due to maternal antibodies
title_sort	intrabursal immunization as a possible route to overcome immunosuppression due to maternal antibodies
publisher	South Valley University
publishDate	2019
url	https://doaj.org/article/aec8420fc8954a6482a296589205711a
work_keys_str_mv	AT elsayedmohammed intrabursalimmunizationasapossibleroutetoovercomeimmunosuppressionduetomaternalantibodies AT mohammedahmed intrabursalimmunizationasapossibleroutetoovercomeimmunosuppressionduetomaternalantibodies
_version_	1718394709614788608

Intrabursal immunization as a possible route to overcome immunosuppression due to maternal antibodies

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