Catatonia in Down syndrome; a treatable cause of regression

Neera Ghaziuddin,1 Armin Nassiri,2 Judith H Miles3 1Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, 2Community Psychiatry, San Jose, California, 3Thompson Center for Autism and Neurodevelopmental Disorders and Department of Child Health, University of Missouri, Columbia, Mis...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ghaziuddin N, Nassiri A, Miles JH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/aec945777c5d4bc89e42b8fa4d2154ea
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:aec945777c5d4bc89e42b8fa4d2154ea
record_format	dspace
spelling	oai:doaj.org-article:aec945777c5d4bc89e42b8fa4d2154ea2021-12-02T00:15:49ZCatatonia in Down syndrome; a treatable cause of regression1178-2021https://doaj.org/article/aec945777c5d4bc89e42b8fa4d2154ea2015-04-01T00:00:00Zhttp://www.dovepress.com/catatonia-in-down-syndrome-a-treatable-causenbspofnbspregression-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Neera Ghaziuddin,1 Armin Nassiri,2 Judith H Miles3 1Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, 2Community Psychiatry, San Jose, California, 3Thompson Center for Autism and Neurodevelopmental Disorders and Department of Child Health, University of Missouri, Columbia, Missouri, USA Objective: The main aim of this case series report is to alert physicians to the occurrence of catatonia in Down syndrome (DS). A second aim is to stimulate the study of regression in DS and of catatonia. A subset of individuals with DS is noted to experience unexplained regression in behavior, mood, activities of daily living, motor activities, and intellectual functioning during adolescence or young adulthood. Depression, early onset Alzheimer’s, or just “the Down syndrome” are often blamed after general medical causes have been ruled out. Clinicians are generally unaware that catatonia, which can cause these symptoms, may occur in DS.Study design: Four DS adolescents who experienced regression are reported. Laboratory tests intended to rule out causes of motor and cognitive regression were within normal limits. Based on the presence of multiple motor disturbances (slowing and/or increased motor activity, grimacing, posturing), the individuals were diagnosed with unspecified catatonia and treated with anti-catatonic treatments (benzodiazepines and electroconvulsive therapy [ECT]).Results: All four cases were treated with a benzodiazepine combined with ECT and recovered their baseline functioning.Conclusion: We suspect catatonia is a common cause of unexplained deterioration in adolescents and young adults with DS. Moreover, pediatricians and others who care for individuals with DS are generally unfamiliar with the catatonia diagnosis outside schizophrenia, resulting in misdiagnosis and years of morbidity. Alerting physicians to catatonia in DS is essential to prompt diagnosis, appropriate treatment, and identification of the frequency and course of this disorder. Keywords: electroconvulsive therapy, benzodiazepines, adolescence, young adulthoodGhaziuddin NNassiri AMiles JHDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 941-949 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ghaziuddin N Nassiri A Miles JH Catatonia in Down syndrome; a treatable cause of regression
description	Neera Ghaziuddin,1 Armin Nassiri,2 Judith H Miles3 1Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, 2Community Psychiatry, San Jose, California, 3Thompson Center for Autism and Neurodevelopmental Disorders and Department of Child Health, University of Missouri, Columbia, Missouri, USA Objective: The main aim of this case series report is to alert physicians to the occurrence of catatonia in Down syndrome (DS). A second aim is to stimulate the study of regression in DS and of catatonia. A subset of individuals with DS is noted to experience unexplained regression in behavior, mood, activities of daily living, motor activities, and intellectual functioning during adolescence or young adulthood. Depression, early onset Alzheimer’s, or just “the Down syndrome” are often blamed after general medical causes have been ruled out. Clinicians are generally unaware that catatonia, which can cause these symptoms, may occur in DS.Study design: Four DS adolescents who experienced regression are reported. Laboratory tests intended to rule out causes of motor and cognitive regression were within normal limits. Based on the presence of multiple motor disturbances (slowing and/or increased motor activity, grimacing, posturing), the individuals were diagnosed with unspecified catatonia and treated with anti-catatonic treatments (benzodiazepines and electroconvulsive therapy [ECT]).Results: All four cases were treated with a benzodiazepine combined with ECT and recovered their baseline functioning.Conclusion: We suspect catatonia is a common cause of unexplained deterioration in adolescents and young adults with DS. Moreover, pediatricians and others who care for individuals with DS are generally unfamiliar with the catatonia diagnosis outside schizophrenia, resulting in misdiagnosis and years of morbidity. Alerting physicians to catatonia in DS is essential to prompt diagnosis, appropriate treatment, and identification of the frequency and course of this disorder. Keywords: electroconvulsive therapy, benzodiazepines, adolescence, young adulthood
format	article
author	Ghaziuddin N Nassiri A Miles JH
author_facet	Ghaziuddin N Nassiri A Miles JH
author_sort	Ghaziuddin N
title	Catatonia in Down syndrome; a treatable cause of regression
title_short	Catatonia in Down syndrome; a treatable cause of regression
title_full	Catatonia in Down syndrome; a treatable cause of regression
title_fullStr	Catatonia in Down syndrome; a treatable cause of regression
title_full_unstemmed	Catatonia in Down syndrome; a treatable cause of regression
title_sort	catatonia in down syndrome; a treatable cause of regression
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/aec945777c5d4bc89e42b8fa4d2154ea
work_keys_str_mv	AT ghaziuddinn catatoniaindownsyndromeatreatablecausenbspofnbspregression AT nassiria catatoniaindownsyndromeatreatablecausenbspofnbspregression AT milesjh catatoniaindownsyndromeatreatablecausenbspofnbspregression
_version_	1718403882267181056

Catatonia in Down syndrome; a treatable cause&nbsp;of&nbsp;regression

Ejemplares similares

Catatonia in Down syndrome; a treatable cause of regression