Clinical and Therapeutic Implications of Epstein–Barr Virus in HIV-Related Lymphomas

The incidence of lymphomas is increased in people living with HIV (PLWH). Aggressive B-cell non-Hodgkin lymphomas (NHLs) are the most common and are considered an AIDS-defining cancer (ADC). Although Hodgkin lymphoma (HL) is not considered an ADC, its incidence is also increased in PLWH. Among all H...

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Autores principales:	Miriam Verdu-Bou, Gustavo Tapia, Agueda Hernandez-Rodriguez, Jose-Tomas Navarro
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Epstein–Barr virus human immunodeficiency virus HIV-related lymphomas Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/aec9ab139c3b4342b559249ac34747ae
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spelling	oai:doaj.org-article:aec9ab139c3b4342b559249ac34747ae2021-11-11T15:34:04ZClinical and Therapeutic Implications of Epstein–Barr Virus in HIV-Related Lymphomas10.3390/cancers132155342072-6694https://doaj.org/article/aec9ab139c3b4342b559249ac34747ae2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5534https://doaj.org/toc/2072-6694The incidence of lymphomas is increased in people living with HIV (PLWH). Aggressive B-cell non-Hodgkin lymphomas (NHLs) are the most common and are considered an AIDS-defining cancer (ADC). Although Hodgkin lymphoma (HL) is not considered an ADC, its incidence is also increased in PLWH. Among all HIV-related lymphomas (HRL), the prevalence of Epstein–Barr virus (EBV) is high. It has been shown that EBV is involved in different lymphomagenic mechanisms mediated by some of its proteins, contributing to the development of different lymphoma subtypes. Additionally, cooperation between both HIV and EBV can lead to the proliferation of aberrant B-cells, thereby being an additional lymphomagenic mechanism in EBV-associated HRL. Despite the close relationship between EBV and HRL, the impact of EBV on clinical aspects has not been extensively studied. These lymphomas are treated with the same therapeutic regimens as the general population in combination with cART. Nevertheless, new therapeutic strategies targeting EBV are promising for these lymphomas. In this article, the different types of HRL are extensively reviewed, focusing on the influence of EBV on the epidemiology, pathogenesis, clinical presentation, and pathological characteristics of each lymphoma subtype. Moreover, novel therapies targeting EBV and future strategies to treat HRL harboring EBV are discussed.Miriam Verdu-BouGustavo TapiaAgueda Hernandez-RodriguezJose-Tomas NavarroMDPI AGarticleEpstein–Barr virushuman immunodeficiency virusHIV-related lymphomasNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5534, p 5534 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Epstein–Barr virus human immunodeficiency virus HIV-related lymphomas Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Epstein–Barr virus human immunodeficiency virus HIV-related lymphomas Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Miriam Verdu-Bou Gustavo Tapia Agueda Hernandez-Rodriguez Jose-Tomas Navarro Clinical and Therapeutic Implications of Epstein–Barr Virus in HIV-Related Lymphomas
description	The incidence of lymphomas is increased in people living with HIV (PLWH). Aggressive B-cell non-Hodgkin lymphomas (NHLs) are the most common and are considered an AIDS-defining cancer (ADC). Although Hodgkin lymphoma (HL) is not considered an ADC, its incidence is also increased in PLWH. Among all HIV-related lymphomas (HRL), the prevalence of Epstein–Barr virus (EBV) is high. It has been shown that EBV is involved in different lymphomagenic mechanisms mediated by some of its proteins, contributing to the development of different lymphoma subtypes. Additionally, cooperation between both HIV and EBV can lead to the proliferation of aberrant B-cells, thereby being an additional lymphomagenic mechanism in EBV-associated HRL. Despite the close relationship between EBV and HRL, the impact of EBV on clinical aspects has not been extensively studied. These lymphomas are treated with the same therapeutic regimens as the general population in combination with cART. Nevertheless, new therapeutic strategies targeting EBV are promising for these lymphomas. In this article, the different types of HRL are extensively reviewed, focusing on the influence of EBV on the epidemiology, pathogenesis, clinical presentation, and pathological characteristics of each lymphoma subtype. Moreover, novel therapies targeting EBV and future strategies to treat HRL harboring EBV are discussed.
format	article
author	Miriam Verdu-Bou Gustavo Tapia Agueda Hernandez-Rodriguez Jose-Tomas Navarro
author_facet	Miriam Verdu-Bou Gustavo Tapia Agueda Hernandez-Rodriguez Jose-Tomas Navarro
author_sort	Miriam Verdu-Bou
title	Clinical and Therapeutic Implications of Epstein–Barr Virus in HIV-Related Lymphomas
title_short	Clinical and Therapeutic Implications of Epstein–Barr Virus in HIV-Related Lymphomas
title_full	Clinical and Therapeutic Implications of Epstein–Barr Virus in HIV-Related Lymphomas
title_fullStr	Clinical and Therapeutic Implications of Epstein–Barr Virus in HIV-Related Lymphomas
title_full_unstemmed	Clinical and Therapeutic Implications of Epstein–Barr Virus in HIV-Related Lymphomas
title_sort	clinical and therapeutic implications of epstein–barr virus in hiv-related lymphomas
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/aec9ab139c3b4342b559249ac34747ae
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Clinical and Therapeutic Implications of Epstein–Barr Virus in HIV-Related Lymphomas

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