Immunomorphological features of female patient’s skin with androgenetic alopecia in the treatment of platelet-rich plasma in combination with topical minoxidil 2 % lotion

The aim. The research was provided to obtain immunohistochemical changes in scalp biopsies of female patients with androgenetic alopecia (AGA) I-II stages according to the Ludwig scale and to detect possible changes after usage of platelet-rich plasma (PRP) injections in combination with topical min...

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Autor principal:	Olena Salyenkova
Formato:	article
Lenguaje:	EN
Publicado:	Scientific Route OÜ 2021
Materias:	androgenetic alopecia female patients platelet-rich plasma topical minoxidil immunohistochemical examination of skin biopsies Medicine R
Acceso en línea:	https://doaj.org/article/aecd8f22c0fa4ccd9c0e0c7adec22c30
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spelling	oai:doaj.org-article:aecd8f22c0fa4ccd9c0e0c7adec22c302021-11-12T09:47:19ZImmunomorphological features of female patient’s skin with androgenetic alopecia in the treatment of platelet-rich plasma in combination with topical minoxidil 2 % lotion2585-66262585-663410.21303/2585-6634.2021.002154https://doaj.org/article/aecd8f22c0fa4ccd9c0e0c7adec22c302021-10-01T00:00:00Zhttp://journal.eu-jr.eu/ttism/article/view/2154https://doaj.org/toc/2585-6626https://doaj.org/toc/2585-6634The aim. The research was provided to obtain immunohistochemical changes in scalp biopsies of female patients with androgenetic alopecia (AGA) I-II stages according to the Ludwig scale and to detect possible changes after usage of platelet-rich plasma (PRP) injections in combination with topical minoxidil 2 % lotion. Materials and methods. Skin biopsies of 30 patients with AGA were examined by immunohistochemistry before and after treatment, which lasted for 3 months and included 3 PRP sessions (once per month) and topical application of minoxidil 2 % lotion twice daily. Results. It was found that AGA is accompanied by inflammatory perifollicular infiltration by T-lymphocytes CD3 +, CD4 + and CD8 +, macrophages (CD68 +); imbalance of growth polypeptides VEGF, TGF-β1, EGFR; accumulation of oxidative stress enzymes eNOS and iNOS; accumulation of pathological fraction of Collagen IV. The use of platelet-rich plasma in combination with topical 2 % minoxidil as AGA therapy leads to the normalization of immunohistochemical parameters of the skin, which indicates the possibility of its use for long-term therapeutic effect. Conclusions. This study supplemented the understanding of the pathogenesis of AGA and serves as the basis for improving treatment regimens for this pathology. But more research is required to further study the pathomorphology of androgenetic alopecia and to standardize the technique of using platelet-rich plasma in patients with this disease.Olena SalyenkovaScientific Route OÜarticleandrogenetic alopeciafemale patientsplatelet-rich plasmatopical minoxidilimmunohistochemical examination of skin biopsiesMedicineRENTechnology Transfer: Innovative Solutions in Medicine, Pp 22-25 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	androgenetic alopecia female patients platelet-rich plasma topical minoxidil immunohistochemical examination of skin biopsies Medicine R
spellingShingle	androgenetic alopecia female patients platelet-rich plasma topical minoxidil immunohistochemical examination of skin biopsies Medicine R Olena Salyenkova Immunomorphological features of female patient’s skin with androgenetic alopecia in the treatment of platelet-rich plasma in combination with topical minoxidil 2 % lotion
description	The aim. The research was provided to obtain immunohistochemical changes in scalp biopsies of female patients with androgenetic alopecia (AGA) I-II stages according to the Ludwig scale and to detect possible changes after usage of platelet-rich plasma (PRP) injections in combination with topical minoxidil 2 % lotion. Materials and methods. Skin biopsies of 30 patients with AGA were examined by immunohistochemistry before and after treatment, which lasted for 3 months and included 3 PRP sessions (once per month) and topical application of minoxidil 2 % lotion twice daily. Results. It was found that AGA is accompanied by inflammatory perifollicular infiltration by T-lymphocytes CD3 +, CD4 + and CD8 +, macrophages (CD68 +); imbalance of growth polypeptides VEGF, TGF-β1, EGFR; accumulation of oxidative stress enzymes eNOS and iNOS; accumulation of pathological fraction of Collagen IV. The use of platelet-rich plasma in combination with topical 2 % minoxidil as AGA therapy leads to the normalization of immunohistochemical parameters of the skin, which indicates the possibility of its use for long-term therapeutic effect. Conclusions. This study supplemented the understanding of the pathogenesis of AGA and serves as the basis for improving treatment regimens for this pathology. But more research is required to further study the pathomorphology of androgenetic alopecia and to standardize the technique of using platelet-rich plasma in patients with this disease.
format	article
author	Olena Salyenkova
author_facet	Olena Salyenkova
author_sort	Olena Salyenkova
title	Immunomorphological features of female patient’s skin with androgenetic alopecia in the treatment of platelet-rich plasma in combination with topical minoxidil 2 % lotion
title_short	Immunomorphological features of female patient’s skin with androgenetic alopecia in the treatment of platelet-rich plasma in combination with topical minoxidil 2 % lotion
title_full	Immunomorphological features of female patient’s skin with androgenetic alopecia in the treatment of platelet-rich plasma in combination with topical minoxidil 2 % lotion
title_fullStr	Immunomorphological features of female patient’s skin with androgenetic alopecia in the treatment of platelet-rich plasma in combination with topical minoxidil 2 % lotion
title_full_unstemmed	Immunomorphological features of female patient’s skin with androgenetic alopecia in the treatment of platelet-rich plasma in combination with topical minoxidil 2 % lotion
title_sort	immunomorphological features of female patient’s skin with androgenetic alopecia in the treatment of platelet-rich plasma in combination with topical minoxidil 2 % lotion
publisher	Scientific Route OÜ
publishDate	2021
url	https://doaj.org/article/aecd8f22c0fa4ccd9c0e0c7adec22c30
work_keys_str_mv	AT olenasalyenkova immunomorphologicalfeaturesoffemalepatientsskinwithandrogeneticalopeciainthetreatmentofplateletrichplasmaincombinationwithtopicalminoxidil2lotion
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Immunomorphological features of female patient’s skin with androgenetic alopecia in the treatment of platelet-rich plasma in combination with topical minoxidil 2 % lotion

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