A PTHrP-2 loaded adhesive cellulose acetate nanofiber mat as wound dressing accelerates wound healing

Although various dressings currently used have the effect of promoting wound healing, they still cannot meet the requirements of clinically efficient treatment. Recently, parathyroid hormone (PTH) and its pathway have been shown as the new target for wound repair. However, using PTH in clinical woun...

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Autores principales:	Ang Li, Zhengzhe Han, Zongyue Li, Jingfeng Li, Xiaolin Li, Zhichang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cellulose acetate nanofiber mat Parathyroid hormone related peptide Electrospinning Wound healing Angiogenesis Materials of engineering and construction. Mechanics of materials TA401-492
Acceso en línea:	https://doaj.org/article/aecd990650b647579a77ad84c6219762
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spelling	oai:doaj.org-article:aecd990650b647579a77ad84c62197622021-11-14T04:28:35ZA PTHrP-2 loaded adhesive cellulose acetate nanofiber mat as wound dressing accelerates wound healing0264-127510.1016/j.matdes.2021.110241https://doaj.org/article/aecd990650b647579a77ad84c62197622021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0264127521007966https://doaj.org/toc/0264-1275Although various dressings currently used have the effect of promoting wound healing, they still cannot meet the requirements of clinically efficient treatment. Recently, parathyroid hormone (PTH) and its pathway have been shown as the new target for wound repair. However, using PTH in clinical wound treatment can be a question. This study is to develop a novel PTHrP-2 loaded cellulose acetate nanofiber mat (CAP) via electrospinning to benefit wound repair. By observing the effects of prepared CAP on cell proliferation, migration, tube formation, and wound healing in the rat models, we have evaluated the safety and effectiveness of CAP. With the extract of CAP, the viability of human umbilical vein endothelial cells and fibroblasts was enhanced. It also could significantly increase the movement rate of human umbilical vein endothelial cells and promote tube formation. The wound closure speed of CAP treatment was significantly faster than the cellulose acetate group. In conclusion, CAP has a promoting effect in angiogenesis, collagen formation and re-epithelialization, thereby it can accelerate wound healing. CAP is a promising translational nanocomposite material, which might be transferred into a new type of wound dressing.Ang LiZhengzhe HanZongyue LiJingfeng LiXiaolin LiZhichang ZhangElsevierarticleCellulose acetate nanofiber matParathyroid hormone related peptideElectrospinningWound healingAngiogenesisMaterials of engineering and construction. Mechanics of materialsTA401-492ENMaterials & Design, Vol 212, Iss , Pp 110241- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cellulose acetate nanofiber mat Parathyroid hormone related peptide Electrospinning Wound healing Angiogenesis Materials of engineering and construction. Mechanics of materials TA401-492
spellingShingle	Cellulose acetate nanofiber mat Parathyroid hormone related peptide Electrospinning Wound healing Angiogenesis Materials of engineering and construction. Mechanics of materials TA401-492 Ang Li Zhengzhe Han Zongyue Li Jingfeng Li Xiaolin Li Zhichang Zhang A PTHrP-2 loaded adhesive cellulose acetate nanofiber mat as wound dressing accelerates wound healing
description	Although various dressings currently used have the effect of promoting wound healing, they still cannot meet the requirements of clinically efficient treatment. Recently, parathyroid hormone (PTH) and its pathway have been shown as the new target for wound repair. However, using PTH in clinical wound treatment can be a question. This study is to develop a novel PTHrP-2 loaded cellulose acetate nanofiber mat (CAP) via electrospinning to benefit wound repair. By observing the effects of prepared CAP on cell proliferation, migration, tube formation, and wound healing in the rat models, we have evaluated the safety and effectiveness of CAP. With the extract of CAP, the viability of human umbilical vein endothelial cells and fibroblasts was enhanced. It also could significantly increase the movement rate of human umbilical vein endothelial cells and promote tube formation. The wound closure speed of CAP treatment was significantly faster than the cellulose acetate group. In conclusion, CAP has a promoting effect in angiogenesis, collagen formation and re-epithelialization, thereby it can accelerate wound healing. CAP is a promising translational nanocomposite material, which might be transferred into a new type of wound dressing.
format	article
author	Ang Li Zhengzhe Han Zongyue Li Jingfeng Li Xiaolin Li Zhichang Zhang
author_facet	Ang Li Zhengzhe Han Zongyue Li Jingfeng Li Xiaolin Li Zhichang Zhang
author_sort	Ang Li
title	A PTHrP-2 loaded adhesive cellulose acetate nanofiber mat as wound dressing accelerates wound healing
title_short	A PTHrP-2 loaded adhesive cellulose acetate nanofiber mat as wound dressing accelerates wound healing
title_full	A PTHrP-2 loaded adhesive cellulose acetate nanofiber mat as wound dressing accelerates wound healing
title_fullStr	A PTHrP-2 loaded adhesive cellulose acetate nanofiber mat as wound dressing accelerates wound healing
title_full_unstemmed	A PTHrP-2 loaded adhesive cellulose acetate nanofiber mat as wound dressing accelerates wound healing
title_sort	pthrp-2 loaded adhesive cellulose acetate nanofiber mat as wound dressing accelerates wound healing
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/aecd990650b647579a77ad84c6219762
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A PTHrP-2 loaded adhesive cellulose acetate nanofiber mat as wound dressing accelerates wound healing

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