Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice

Abstract We previously showed that Irisin, a myokine released from skeletal muscle after physical exercise, plays a central role in the control of bone mass. Here we report that treatment with recombinant Irisin prevented bone loss in hind-limb suspended mice when administered during suspension (pre...

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Autores principales:	Graziana Colaianni, Teresa Mongelli, Concetta Cuscito, Paolo Pignataro, Luciana Lippo, Giovanna Spiro, Angela Notarnicola, Ilenia Severi, Giovanni Passeri, Giorgio Mori, Giacomina Brunetti, Biagio Moretti, Umberto Tarantino, Silvia C. Colucci, Janne E. Reseland, Roberto Vettor, Saverio Cinti, Maria Grano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aecf262e9cb6466ebcc6d4295e7d1e2e
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spelling	oai:doaj.org-article:aecf262e9cb6466ebcc6d4295e7d1e2e2021-12-02T16:06:07ZIrisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice10.1038/s41598-017-02557-82045-2322https://doaj.org/article/aecf262e9cb6466ebcc6d4295e7d1e2e2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02557-8https://doaj.org/toc/2045-2322Abstract We previously showed that Irisin, a myokine released from skeletal muscle after physical exercise, plays a central role in the control of bone mass. Here we report that treatment with recombinant Irisin prevented bone loss in hind-limb suspended mice when administered during suspension (preventive protocol) and induced recovery of bone mass when mice were injected after bone loss due to a suspension period of 4 weeks (curative protocol). MicroCT analysis of femurs showed that r-Irisin preserved both cortical and trabecular bone mineral density, and prevented a dramatic decrease of the trabecular bone volume fraction. Moreover, r-Irisin protected against muscle mass decline in the hind-limb suspended mice, and maintained the fiber cross-sectional area. Notably, the decrease of myosin type II expression in unloaded mice was completely prevented by r-Irisin administration. Our data reveal for the first time that Irisin retrieves disuse‐induced bone loss and muscle atrophy. These findings may lead to development of an Irisin-based therapy for elderly immobile osteoporotic and physically disable patients, and might represent a countermeasure for astronauts subjected to microgravity-induced bone and muscle losses.Graziana ColaianniTeresa MongelliConcetta CuscitoPaolo PignataroLuciana LippoGiovanna SpiroAngela NotarnicolaIlenia SeveriGiovanni PasseriGiorgio MoriGiacomina BrunettiBiagio MorettiUmberto TarantinoSilvia C. ColucciJanne E. ReselandRoberto VettorSaverio CintiMaria GranoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Graziana Colaianni Teresa Mongelli Concetta Cuscito Paolo Pignataro Luciana Lippo Giovanna Spiro Angela Notarnicola Ilenia Severi Giovanni Passeri Giorgio Mori Giacomina Brunetti Biagio Moretti Umberto Tarantino Silvia C. Colucci Janne E. Reseland Roberto Vettor Saverio Cinti Maria Grano Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice
description	Abstract We previously showed that Irisin, a myokine released from skeletal muscle after physical exercise, plays a central role in the control of bone mass. Here we report that treatment with recombinant Irisin prevented bone loss in hind-limb suspended mice when administered during suspension (preventive protocol) and induced recovery of bone mass when mice were injected after bone loss due to a suspension period of 4 weeks (curative protocol). MicroCT analysis of femurs showed that r-Irisin preserved both cortical and trabecular bone mineral density, and prevented a dramatic decrease of the trabecular bone volume fraction. Moreover, r-Irisin protected against muscle mass decline in the hind-limb suspended mice, and maintained the fiber cross-sectional area. Notably, the decrease of myosin type II expression in unloaded mice was completely prevented by r-Irisin administration. Our data reveal for the first time that Irisin retrieves disuse‐induced bone loss and muscle atrophy. These findings may lead to development of an Irisin-based therapy for elderly immobile osteoporotic and physically disable patients, and might represent a countermeasure for astronauts subjected to microgravity-induced bone and muscle losses.
format	article
author	Graziana Colaianni Teresa Mongelli Concetta Cuscito Paolo Pignataro Luciana Lippo Giovanna Spiro Angela Notarnicola Ilenia Severi Giovanni Passeri Giorgio Mori Giacomina Brunetti Biagio Moretti Umberto Tarantino Silvia C. Colucci Janne E. Reseland Roberto Vettor Saverio Cinti Maria Grano
author_facet	Graziana Colaianni Teresa Mongelli Concetta Cuscito Paolo Pignataro Luciana Lippo Giovanna Spiro Angela Notarnicola Ilenia Severi Giovanni Passeri Giorgio Mori Giacomina Brunetti Biagio Moretti Umberto Tarantino Silvia C. Colucci Janne E. Reseland Roberto Vettor Saverio Cinti Maria Grano
author_sort	Graziana Colaianni
title	Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice
title_short	Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice
title_full	Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice
title_fullStr	Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice
title_full_unstemmed	Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice
title_sort	irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/aecf262e9cb6466ebcc6d4295e7d1e2e
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Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice

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