Intracellular artificial supramolecules based on de novo designed Y15 peptides

Self-assembling peptides (SAPs) can be used to build biomaterials, but genetically encoded SAPs have rarely been used as building blocks in cells. Here, the authors design a SAP that can be genetically fused to target proteins to induce their intracellular clustering and modulate their signaling fun...

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Main Authors:	Takayuki Miki, Taichi Nakai, Masahiro Hashimoto, Keigo Kajiwara, Hiroshi Tsutsumi, Hisakazu Mihara
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/aed0717ccedf4fe4990fdba0e05fbb07
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spelling	oai:doaj.org-article:aed0717ccedf4fe4990fdba0e05fbb072021-12-02T17:52:09ZIntracellular artificial supramolecules based on de novo designed Y15 peptides10.1038/s41467-021-23794-62041-1723https://doaj.org/article/aed0717ccedf4fe4990fdba0e05fbb072021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23794-6https://doaj.org/toc/2041-1723Self-assembling peptides (SAPs) can be used to build biomaterials, but genetically encoded SAPs have rarely been used as building blocks in cells. Here, the authors design a SAP that can be genetically fused to target proteins to induce their intracellular clustering and modulate their signaling functions.Takayuki MikiTaichi NakaiMasahiro HashimotoKeigo KajiwaraHiroshi TsutsumiHisakazu MiharaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takayuki Miki Taichi Nakai Masahiro Hashimoto Keigo Kajiwara Hiroshi Tsutsumi Hisakazu Mihara Intracellular artificial supramolecules based on de novo designed Y15 peptides
description	Self-assembling peptides (SAPs) can be used to build biomaterials, but genetically encoded SAPs have rarely been used as building blocks in cells. Here, the authors design a SAP that can be genetically fused to target proteins to induce their intracellular clustering and modulate their signaling functions.
format	article
author	Takayuki Miki Taichi Nakai Masahiro Hashimoto Keigo Kajiwara Hiroshi Tsutsumi Hisakazu Mihara
author_facet	Takayuki Miki Taichi Nakai Masahiro Hashimoto Keigo Kajiwara Hiroshi Tsutsumi Hisakazu Mihara
author_sort	Takayuki Miki
title	Intracellular artificial supramolecules based on de novo designed Y15 peptides
title_short	Intracellular artificial supramolecules based on de novo designed Y15 peptides
title_full	Intracellular artificial supramolecules based on de novo designed Y15 peptides
title_fullStr	Intracellular artificial supramolecules based on de novo designed Y15 peptides
title_full_unstemmed	Intracellular artificial supramolecules based on de novo designed Y15 peptides
title_sort	intracellular artificial supramolecules based on de novo designed y15 peptides
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aed0717ccedf4fe4990fdba0e05fbb07
work_keys_str_mv	AT takayukimiki intracellularartificialsupramoleculesbasedondenovodesignedy15peptides AT taichinakai intracellularartificialsupramoleculesbasedondenovodesignedy15peptides AT masahirohashimoto intracellularartificialsupramoleculesbasedondenovodesignedy15peptides AT keigokajiwara intracellularartificialsupramoleculesbasedondenovodesignedy15peptides AT hiroshitsutsumi intracellularartificialsupramoleculesbasedondenovodesignedy15peptides AT hisakazumihara intracellularartificialsupramoleculesbasedondenovodesignedy15peptides
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Intracellular artificial supramolecules based on de novo designed Y15 peptides

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