The role of calcifying nanoparticles in biology and medicine

Anton G Kutikhin, Elena B Brusina, Arseniy E YuzhalinDepartment of Epidemiology, Kemerovo State Medical Academy, Kemerovo, Russian FederationAbstract: Calcifying nanoparticles (CNPs) (nanobacteria, nanobacteria-like particles, nanobes) were discovered over 25 years ago; nevertheless, their nature is...

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Autores principales:	Kutikhin AG, Brusina EB, Yuzhalin AE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/aed167f2f3a34b7ebff51cd5bb8e9650
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spelling	oai:doaj.org-article:aed167f2f3a34b7ebff51cd5bb8e96502021-12-02T04:25:22ZThe role of calcifying nanoparticles in biology and medicine1176-91141178-2013https://doaj.org/article/aed167f2f3a34b7ebff51cd5bb8e96502012-01-01T00:00:00Zhttp://www.dovepress.com/the-role-of-calcifying-nanoparticles-in-biology-and-medicine-a9099https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Anton G Kutikhin, Elena B Brusina, Arseniy E YuzhalinDepartment of Epidemiology, Kemerovo State Medical Academy, Kemerovo, Russian FederationAbstract: Calcifying nanoparticles (CNPs) (nanobacteria, nanobacteria-like particles, nanobes) were discovered over 25 years ago; nevertheless, their nature is still obscure. To date, nobody has been successful in credibly determining whether they are the smallest self-replicating life form on Earth, or whether they represent mineralo-protein complexes without any relation to living organisms. Proponents of both theories have a number of arguments in favor of the validity of their hypotheses. However, after epistemological analysis carried out in this review, all arguments used by proponents of the theory about the physicochemical model of CNP formation may be refuted on the basis of the performed investigations, and therefore published data suggest a biological nature of CNPs. The only obstacle to establish CNPs as living organisms is the absence of a fairly accurately sequenced genome at the present time. Moreover, it is clear that CNPs play an important role in etiopathogenesis of many diseases, and this association is independent from their nature. Consequently, emergence of CNPs in an organism is a pathological, not a physiological, process. The classification and new directions of further investigations devoted to the role of CNPs in biology and medicine are proposed.Keywords: nanobacteria, nanobacteria-like particles, diseases, infectious agents, hydroxyapatiteKutikhin AGBrusina EBYuzhalin AEDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 339-350 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Kutikhin AG Brusina EB Yuzhalin AE The role of calcifying nanoparticles in biology and medicine
description	Anton G Kutikhin, Elena B Brusina, Arseniy E YuzhalinDepartment of Epidemiology, Kemerovo State Medical Academy, Kemerovo, Russian FederationAbstract: Calcifying nanoparticles (CNPs) (nanobacteria, nanobacteria-like particles, nanobes) were discovered over 25 years ago; nevertheless, their nature is still obscure. To date, nobody has been successful in credibly determining whether they are the smallest self-replicating life form on Earth, or whether they represent mineralo-protein complexes without any relation to living organisms. Proponents of both theories have a number of arguments in favor of the validity of their hypotheses. However, after epistemological analysis carried out in this review, all arguments used by proponents of the theory about the physicochemical model of CNP formation may be refuted on the basis of the performed investigations, and therefore published data suggest a biological nature of CNPs. The only obstacle to establish CNPs as living organisms is the absence of a fairly accurately sequenced genome at the present time. Moreover, it is clear that CNPs play an important role in etiopathogenesis of many diseases, and this association is independent from their nature. Consequently, emergence of CNPs in an organism is a pathological, not a physiological, process. The classification and new directions of further investigations devoted to the role of CNPs in biology and medicine are proposed.Keywords: nanobacteria, nanobacteria-like particles, diseases, infectious agents, hydroxyapatite
format	article
author	Kutikhin AG Brusina EB Yuzhalin AE
author_facet	Kutikhin AG Brusina EB Yuzhalin AE
author_sort	Kutikhin AG
title	The role of calcifying nanoparticles in biology and medicine
title_short	The role of calcifying nanoparticles in biology and medicine
title_full	The role of calcifying nanoparticles in biology and medicine
title_fullStr	The role of calcifying nanoparticles in biology and medicine
title_full_unstemmed	The role of calcifying nanoparticles in biology and medicine
title_sort	role of calcifying nanoparticles in biology and medicine
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/aed167f2f3a34b7ebff51cd5bb8e9650
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The role of calcifying nanoparticles in biology and medicine

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