Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function

The metabolic regulator protein family, mTOR, regulate natural killer (NK) cell development and function, but the underlying mechanism is unclear. Here, the authors show that Raptor/mTORC1 and Rictor/mTORC2 form a feedback crosstalk network to variegate cytokine and cellular signaling and modulate N...

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Autores principales:	Fangjie Wang, Meng Meng, Banghui Mo, Yao Yang, Yan Ji, Pei Huang, Wenjing Lai, Xiaodong Pan, Tingting You, Hongqin Luo, Xiao Guan, Yafei Deng, Shunzong Yuan, Jianhong Chu, Michael Namaka, Tiffany Hughes, Lilin Ye, Jianhua Yu, Xiaohui Li, Youcai Deng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aed5a9a2b75b4c99ac71c6c1c1c72f87
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spelling	oai:doaj.org-article:aed5a9a2b75b4c99ac71c6c1c1c72f872021-12-02T16:56:37ZCrosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function10.1038/s41467-018-07277-92041-1723https://doaj.org/article/aed5a9a2b75b4c99ac71c6c1c1c72f872018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07277-9https://doaj.org/toc/2041-1723The metabolic regulator protein family, mTOR, regulate natural killer (NK) cell development and function, but the underlying mechanism is unclear. Here, the authors show that Raptor/mTORC1 and Rictor/mTORC2 form a feedback crosstalk network to variegate cytokine and cellular signaling and modulate NK maturation and effector functions.Fangjie WangMeng MengBanghui MoYao YangYan JiPei HuangWenjing LaiXiaodong PanTingting YouHongqin LuoXiao GuanYafei DengShunzong YuanJianhong ChuMichael NamakaTiffany HughesLilin YeJianhua YuXiaohui LiYoucai DengNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fangjie Wang Meng Meng Banghui Mo Yao Yang Yan Ji Pei Huang Wenjing Lai Xiaodong Pan Tingting You Hongqin Luo Xiao Guan Yafei Deng Shunzong Yuan Jianhong Chu Michael Namaka Tiffany Hughes Lilin Ye Jianhua Yu Xiaohui Li Youcai Deng Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
description	The metabolic regulator protein family, mTOR, regulate natural killer (NK) cell development and function, but the underlying mechanism is unclear. Here, the authors show that Raptor/mTORC1 and Rictor/mTORC2 form a feedback crosstalk network to variegate cytokine and cellular signaling and modulate NK maturation and effector functions.
format	article
author	Fangjie Wang Meng Meng Banghui Mo Yao Yang Yan Ji Pei Huang Wenjing Lai Xiaodong Pan Tingting You Hongqin Luo Xiao Guan Yafei Deng Shunzong Yuan Jianhong Chu Michael Namaka Tiffany Hughes Lilin Ye Jianhua Yu Xiaohui Li Youcai Deng
author_facet	Fangjie Wang Meng Meng Banghui Mo Yao Yang Yan Ji Pei Huang Wenjing Lai Xiaodong Pan Tingting You Hongqin Luo Xiao Guan Yafei Deng Shunzong Yuan Jianhong Chu Michael Namaka Tiffany Hughes Lilin Ye Jianhua Yu Xiaohui Li Youcai Deng
author_sort	Fangjie Wang
title	Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
title_short	Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
title_full	Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
title_fullStr	Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
title_full_unstemmed	Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
title_sort	crosstalks between mtorc1 and mtorc2 variagate cytokine signaling to control nk maturation and effector function
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/aed5a9a2b75b4c99ac71c6c1c1c72f87
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Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function

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