Comparison of Behavioral Risk Factors and Cardiometabolic Comorbidities of Psoriatic Arthritis and Psoriasis: A Case–Control Study in Chinese Patients
Qiaolin Wang,1– 3 Yan Luo,1– 3 Menglin Chen,1– 3 Xuanwei Zheng,1– 3 Wu Zhu,1– 3 Minxue Shen,1– 4 Yehong Kuang1– 3 1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republi...
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2021
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oai:doaj.org-article:aed9ad7c712440acb8162fe53be510802021-12-02T16:53:14ZComparison of Behavioral Risk Factors and Cardiometabolic Comorbidities of Psoriatic Arthritis and Psoriasis: A Case–Control Study in Chinese Patients1178-203Xhttps://doaj.org/article/aed9ad7c712440acb8162fe53be510802021-05-01T00:00:00Zhttps://www.dovepress.com/comparison-of-behavioral-risk-factors-and-cardiometabolic-comorbiditie-peer-reviewed-fulltext-article-TCRMhttps://doaj.org/toc/1178-203XQiaolin Wang,1– 3 Yan Luo,1– 3 Menglin Chen,1– 3 Xuanwei Zheng,1– 3 Wu Zhu,1– 3 Minxue Shen,1– 4 Yehong Kuang1– 3 1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China; 2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, 410008, People’s Republic of China; 3Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis (Xiangya Hospital), Changsha, 410008, People’s Republic of China; 4Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, 410078, People’s Republic of ChinaCorrespondence: Yehong Kuang; Minxue ShenDepartment of Dermatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, People’s Republic of ChinaTel +86-13574171102; +86-15973164022Email yh_927@126.com; shenmx1988@csu.edu.cnPurpose: Comparison of risk factors and comorbidities could help indicate the underlying mechanisms of diseases. This study aimed to compare behavioral factors and cardiometabolic comorbidities of PsA/psoriasis versus healthy controls to implicate the similarities and differences in potential pathogenic mechanisms for further research.Patients and Methods: A case-control study in Chinese patients with PsA or psoriasis and healthy controls was conducted. Clinical information based on patient-reported and measured outcomes were collected. Multivariable logistic regression was used to investigate the associations, in terms of adjusted odds ratios (AORs).Results: We randomly selected 171 patients with PsA, 342 with psoriasis, and 1026 healthy controls from our database, matching by age and sex. Dyslipidemia (AOR=4.62 for PsA and 2.97 for psoriasis) and alcohol drinking (AOR=3.20 for PsA and 3.62 for psoriasis) were significantly associated with both diseases. Overweight was inversely associated with both PsA (AOR=0.46, P=0.002) and psoriasis (AOR=0.56, P=0.001), while obesity was associated with PsA (AOR=2.02, P=0.025) but not psoriasis (AOR=0.87, P=0.621). Subgroup analysis by onset age of psoriatic lesions showed that former smoking was significantly associated with early-onset psoriasis (AOR=2.44, P=0.016) but not PsA (AOR=0.59, P=0.329). Laboratory test indicated that both PsA and psoriasis were associated with altered lipid profile.Conclusion: PsA and psoriasis in Chinese patients share common behavioral and cardiometabolic risk factors including dyslipidemia and alcohol consumption. There is a U-shape association between BMI and PsA/psoriasis.Keywords: psoriatic arthritis, psoriasis, comorbidities, obesity, smoking, alcoholWang QLuo YChen MZheng XZhu WShen MKuang YDove Medical Pressarticlepsoriatic arthritispsoriasiscomorbiditiesobesitysmokingalcohol.Therapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 17, Pp 397-404 (2021) |
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DOAJ |
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EN |
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psoriatic arthritis psoriasis comorbidities obesity smoking alcohol. Therapeutics. Pharmacology RM1-950 |
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psoriatic arthritis psoriasis comorbidities obesity smoking alcohol. Therapeutics. Pharmacology RM1-950 Wang Q Luo Y Chen M Zheng X Zhu W Shen M Kuang Y Comparison of Behavioral Risk Factors and Cardiometabolic Comorbidities of Psoriatic Arthritis and Psoriasis: A Case–Control Study in Chinese Patients |
| description |
Qiaolin Wang,1– 3 Yan Luo,1– 3 Menglin Chen,1– 3 Xuanwei Zheng,1– 3 Wu Zhu,1– 3 Minxue Shen,1– 4 Yehong Kuang1– 3 1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China; 2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, 410008, People’s Republic of China; 3Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis (Xiangya Hospital), Changsha, 410008, People’s Republic of China; 4Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, 410078, People’s Republic of ChinaCorrespondence: Yehong Kuang; Minxue ShenDepartment of Dermatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, People’s Republic of ChinaTel +86-13574171102; +86-15973164022Email yh_927@126.com; shenmx1988@csu.edu.cnPurpose: Comparison of risk factors and comorbidities could help indicate the underlying mechanisms of diseases. This study aimed to compare behavioral factors and cardiometabolic comorbidities of PsA/psoriasis versus healthy controls to implicate the similarities and differences in potential pathogenic mechanisms for further research.Patients and Methods: A case-control study in Chinese patients with PsA or psoriasis and healthy controls was conducted. Clinical information based on patient-reported and measured outcomes were collected. Multivariable logistic regression was used to investigate the associations, in terms of adjusted odds ratios (AORs).Results: We randomly selected 171 patients with PsA, 342 with psoriasis, and 1026 healthy controls from our database, matching by age and sex. Dyslipidemia (AOR=4.62 for PsA and 2.97 for psoriasis) and alcohol drinking (AOR=3.20 for PsA and 3.62 for psoriasis) were significantly associated with both diseases. Overweight was inversely associated with both PsA (AOR=0.46, P=0.002) and psoriasis (AOR=0.56, P=0.001), while obesity was associated with PsA (AOR=2.02, P=0.025) but not psoriasis (AOR=0.87, P=0.621). Subgroup analysis by onset age of psoriatic lesions showed that former smoking was significantly associated with early-onset psoriasis (AOR=2.44, P=0.016) but not PsA (AOR=0.59, P=0.329). Laboratory test indicated that both PsA and psoriasis were associated with altered lipid profile.Conclusion: PsA and psoriasis in Chinese patients share common behavioral and cardiometabolic risk factors including dyslipidemia and alcohol consumption. There is a U-shape association between BMI and PsA/psoriasis.Keywords: psoriatic arthritis, psoriasis, comorbidities, obesity, smoking, alcohol |
| format |
article |
| author |
Wang Q Luo Y Chen M Zheng X Zhu W Shen M Kuang Y |
| author_facet |
Wang Q Luo Y Chen M Zheng X Zhu W Shen M Kuang Y |
| author_sort |
Wang Q |
| title |
Comparison of Behavioral Risk Factors and Cardiometabolic Comorbidities of Psoriatic Arthritis and Psoriasis: A Case–Control Study in Chinese Patients |
| title_short |
Comparison of Behavioral Risk Factors and Cardiometabolic Comorbidities of Psoriatic Arthritis and Psoriasis: A Case–Control Study in Chinese Patients |
| title_full |
Comparison of Behavioral Risk Factors and Cardiometabolic Comorbidities of Psoriatic Arthritis and Psoriasis: A Case–Control Study in Chinese Patients |
| title_fullStr |
Comparison of Behavioral Risk Factors and Cardiometabolic Comorbidities of Psoriatic Arthritis and Psoriasis: A Case–Control Study in Chinese Patients |
| title_full_unstemmed |
Comparison of Behavioral Risk Factors and Cardiometabolic Comorbidities of Psoriatic Arthritis and Psoriasis: A Case–Control Study in Chinese Patients |
| title_sort |
comparison of behavioral risk factors and cardiometabolic comorbidities of psoriatic arthritis and psoriasis: a case–control study in chinese patients |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/aed9ad7c712440acb8162fe53be51080 |
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