The Light Chain Defines the Duration of Action of Botulinum Toxin Serotype A Subtypes

The Light Chain Defines the Duration of Action of Botulinum Toxin Serotype A Subtypes

ABSTRACT Botulinum neurotoxin (BoNT) is the causative agent of botulism and a widely used pharmaceutical to treat a variety of neurological diseases. BoNTs are 150-kDa protein toxins organized into heavy chain (HC) and light chain (LC) domains linked by a disulfide bond. The HC selectively binds to...

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Autores principales: Sabine Pellett, Marite Bradshaw, William H. Tepp, Christina L. Pier, Regina C. M. Whitemarsh, Chen Chen, Joseph T. Barbieri, Eric A. Johnson
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
BoNT
botulinum neurotoxin
duration of action
hybrid toxin
subtype
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/aedc52e97f8748b7906c9ad8d9dcb24e
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