Football and team handball training postpone cellular aging in women

Abstract Several hallmarks of aging have been identified and examined separately in previous exercise studies. For the first time, this study investigates the effect of lifelong regular exercise in humans on two of the central aging hallmarks combined. This cross-sectional study involved 129 healthy...

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Autores principales:	Marie Hagman, Bjørn Fristrup, Rémi Michelin, Peter Krustrup, Muhammad Asghar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aee0bbef15aa4512829288dcf37f2c61
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spelling	oai:doaj.org-article:aee0bbef15aa4512829288dcf37f2c612021-12-02T18:25:03ZFootball and team handball training postpone cellular aging in women10.1038/s41598-021-91255-72045-2322https://doaj.org/article/aee0bbef15aa4512829288dcf37f2c612021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91255-7https://doaj.org/toc/2045-2322Abstract Several hallmarks of aging have been identified and examined separately in previous exercise studies. For the first time, this study investigates the effect of lifelong regular exercise in humans on two of the central aging hallmarks combined. This cross-sectional study involved 129 healthy, non-smoking women, including young elite football players (YF, n = 29), young untrained controls (YC, n = 30), elderly team handball players (EH, n = 35) and elderly untrained controls (EC, n = 35). From a resting blood sample, mononuclear cells (MNCs) were isolated and sorted into monocytes and lymphocytes. Telomere length, mitochondrial (mtDNA) copy number and key regulators of mitochondrial biogenesis and function (PGC-1α and PGC-1β expression) were measured using quantitative polymerase chain reaction (qPCR). Overall, young women showed significantly longer telomeres and higher PGC-1α and PGC-1β expression, but lower mtDNA copy number compared to elderly subjects. A multivariate analysis showed that YF had 22–24% longer telomeres in lymphocytes and MNCs compared to YC. In addition, YF showed 19–20% higher mtDNA copy number in lymphocytes and MNCs compared to YC. The two young groups did not differ in PGC-1α and PGC-1β expression. EH showed 14% lower mtDNA copy number in lymphocytes compared to EC, but 3.4-fold higher lymphocyte PGC-1α expression compared to EC. In MNCs, EH also showed 1.4–1.6-fold higher PGC-1α and PGC-1β expression. The two elderly groups did not differ in telomere length. Elite football training and lifelong team handball training are associated with anti-aging mechanisms in leukocytes in women, including maintenance of telomere length and superior mitochondrial characteristics.Marie HagmanBjørn FristrupRémi MichelinPeter KrustrupMuhammad AsgharNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie Hagman Bjørn Fristrup Rémi Michelin Peter Krustrup Muhammad Asghar Football and team handball training postpone cellular aging in women
description	Abstract Several hallmarks of aging have been identified and examined separately in previous exercise studies. For the first time, this study investigates the effect of lifelong regular exercise in humans on two of the central aging hallmarks combined. This cross-sectional study involved 129 healthy, non-smoking women, including young elite football players (YF, n = 29), young untrained controls (YC, n = 30), elderly team handball players (EH, n = 35) and elderly untrained controls (EC, n = 35). From a resting blood sample, mononuclear cells (MNCs) were isolated and sorted into monocytes and lymphocytes. Telomere length, mitochondrial (mtDNA) copy number and key regulators of mitochondrial biogenesis and function (PGC-1α and PGC-1β expression) were measured using quantitative polymerase chain reaction (qPCR). Overall, young women showed significantly longer telomeres and higher PGC-1α and PGC-1β expression, but lower mtDNA copy number compared to elderly subjects. A multivariate analysis showed that YF had 22–24% longer telomeres in lymphocytes and MNCs compared to YC. In addition, YF showed 19–20% higher mtDNA copy number in lymphocytes and MNCs compared to YC. The two young groups did not differ in PGC-1α and PGC-1β expression. EH showed 14% lower mtDNA copy number in lymphocytes compared to EC, but 3.4-fold higher lymphocyte PGC-1α expression compared to EC. In MNCs, EH also showed 1.4–1.6-fold higher PGC-1α and PGC-1β expression. The two elderly groups did not differ in telomere length. Elite football training and lifelong team handball training are associated with anti-aging mechanisms in leukocytes in women, including maintenance of telomere length and superior mitochondrial characteristics.
format	article
author	Marie Hagman Bjørn Fristrup Rémi Michelin Peter Krustrup Muhammad Asghar
author_facet	Marie Hagman Bjørn Fristrup Rémi Michelin Peter Krustrup Muhammad Asghar
author_sort	Marie Hagman
title	Football and team handball training postpone cellular aging in women
title_short	Football and team handball training postpone cellular aging in women
title_full	Football and team handball training postpone cellular aging in women
title_fullStr	Football and team handball training postpone cellular aging in women
title_full_unstemmed	Football and team handball training postpone cellular aging in women
title_sort	football and team handball training postpone cellular aging in women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aee0bbef15aa4512829288dcf37f2c61
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Football and team handball training postpone cellular aging in women

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