Resistance to Antibiotics in Thermophilic Campylobacters

Campylobacter jejuni (C. jejuni) is one of the most frequent causes of bacterial enterocolitis globally. The disease in human is usually self-limiting, but when complications arise antibiotic therapy is required at a time when resistance to antibiotics is increasing worldwide. Mechanisms of antibiot...

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Autores principales: Ema Aleksić, Biljana Miljković-Selimović, Zoran Tambur, Nikola Aleksić, Vladimir Biočanin, Stevan Avramov
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Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/aee82740ad694eb1ad0633d1b7959be7
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spelling oai:doaj.org-article:aee82740ad694eb1ad0633d1b7959be72021-11-11T07:17:54ZResistance to Antibiotics in Thermophilic Campylobacters2296-858X10.3389/fmed.2021.763434https://doaj.org/article/aee82740ad694eb1ad0633d1b7959be72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.763434/fullhttps://doaj.org/toc/2296-858XCampylobacter jejuni (C. jejuni) is one of the most frequent causes of bacterial enterocolitis globally. The disease in human is usually self-limiting, but when complications arise antibiotic therapy is required at a time when resistance to antibiotics is increasing worldwide. Mechanisms of antibiotic resistance in bacteria are diverse depending on antibiotic type and usage and include: enzymatic destruction or drug inactivation; alteration of the target enzyme; alteration of cell membrane permeability; alteration of ribosome structure and alteration of the metabolic pathway(s). Resistance of Campylobacter spp. to antibiotics, especially fluoroquinolones is now a major public health problem in developed and developing countries. In this review the mechanisms of resistance to fluoroquinolones, macrolides, tetracycline, aminoglycoside and the role of integrons in resistance of Campylobacter (especially at the molecular level) are discussed, as well as the mechanisms of resistance to β-lactam antibiotics, sulphonamides and trimethoprim. Multiple drug resistance is an increasing problem for treatment of campylobacter infections and emergence of resistant strains and resistance are important One Health issues.Ema AleksićBiljana Miljković-SelimovićZoran TamburNikola AleksićNikola AleksićVladimir BiočaninStevan AvramovStevan AvramovFrontiers Media S.A.articlecampylobacterantibiotic resistancemechanisms of resistancebacterial enterocolitissignificance of resistant strainsMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution DOAJ
collection DOAJ
language EN
topic campylobacter
antibiotic resistance
mechanisms of resistance
bacterial enterocolitis
significance of resistant strains
Medicine (General)
R5-920
spellingShingle campylobacter
antibiotic resistance
mechanisms of resistance
bacterial enterocolitis
significance of resistant strains
Medicine (General)
R5-920
Ema Aleksić
Biljana Miljković-Selimović
Zoran Tambur
Nikola Aleksić
Nikola Aleksić
Vladimir Biočanin
Stevan Avramov
Stevan Avramov
Resistance to Antibiotics in Thermophilic Campylobacters
description Campylobacter jejuni (C. jejuni) is one of the most frequent causes of bacterial enterocolitis globally. The disease in human is usually self-limiting, but when complications arise antibiotic therapy is required at a time when resistance to antibiotics is increasing worldwide. Mechanisms of antibiotic resistance in bacteria are diverse depending on antibiotic type and usage and include: enzymatic destruction or drug inactivation; alteration of the target enzyme; alteration of cell membrane permeability; alteration of ribosome structure and alteration of the metabolic pathway(s). Resistance of Campylobacter spp. to antibiotics, especially fluoroquinolones is now a major public health problem in developed and developing countries. In this review the mechanisms of resistance to fluoroquinolones, macrolides, tetracycline, aminoglycoside and the role of integrons in resistance of Campylobacter (especially at the molecular level) are discussed, as well as the mechanisms of resistance to β-lactam antibiotics, sulphonamides and trimethoprim. Multiple drug resistance is an increasing problem for treatment of campylobacter infections and emergence of resistant strains and resistance are important One Health issues.
format article
author Ema Aleksić
Biljana Miljković-Selimović
Zoran Tambur
Nikola Aleksić
Nikola Aleksić
Vladimir Biočanin
Stevan Avramov
Stevan Avramov
author_facet Ema Aleksić
Biljana Miljković-Selimović
Zoran Tambur
Nikola Aleksić
Nikola Aleksić
Vladimir Biočanin
Stevan Avramov
Stevan Avramov
author_sort Ema Aleksić
title Resistance to Antibiotics in Thermophilic Campylobacters
title_short Resistance to Antibiotics in Thermophilic Campylobacters
title_full Resistance to Antibiotics in Thermophilic Campylobacters
title_fullStr Resistance to Antibiotics in Thermophilic Campylobacters
title_full_unstemmed Resistance to Antibiotics in Thermophilic Campylobacters
title_sort resistance to antibiotics in thermophilic campylobacters
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/aee82740ad694eb1ad0633d1b7959be7
work_keys_str_mv AT emaaleksic resistancetoantibioticsinthermophiliccampylobacters
AT biljanamiljkovicselimovic resistancetoantibioticsinthermophiliccampylobacters
AT zorantambur resistancetoantibioticsinthermophiliccampylobacters
AT nikolaaleksic resistancetoantibioticsinthermophiliccampylobacters
AT nikolaaleksic resistancetoantibioticsinthermophiliccampylobacters
AT vladimirbiocanin resistancetoantibioticsinthermophiliccampylobacters
AT stevanavramov resistancetoantibioticsinthermophiliccampylobacters
AT stevanavramov resistancetoantibioticsinthermophiliccampylobacters
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