Resistance to Antibiotics in Thermophilic Campylobacters
Campylobacter jejuni (C. jejuni) is one of the most frequent causes of bacterial enterocolitis globally. The disease in human is usually self-limiting, but when complications arise antibiotic therapy is required at a time when resistance to antibiotics is increasing worldwide. Mechanisms of antibiot...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:aee82740ad694eb1ad0633d1b7959be72021-11-11T07:17:54ZResistance to Antibiotics in Thermophilic Campylobacters2296-858X10.3389/fmed.2021.763434https://doaj.org/article/aee82740ad694eb1ad0633d1b7959be72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.763434/fullhttps://doaj.org/toc/2296-858XCampylobacter jejuni (C. jejuni) is one of the most frequent causes of bacterial enterocolitis globally. The disease in human is usually self-limiting, but when complications arise antibiotic therapy is required at a time when resistance to antibiotics is increasing worldwide. Mechanisms of antibiotic resistance in bacteria are diverse depending on antibiotic type and usage and include: enzymatic destruction or drug inactivation; alteration of the target enzyme; alteration of cell membrane permeability; alteration of ribosome structure and alteration of the metabolic pathway(s). Resistance of Campylobacter spp. to antibiotics, especially fluoroquinolones is now a major public health problem in developed and developing countries. In this review the mechanisms of resistance to fluoroquinolones, macrolides, tetracycline, aminoglycoside and the role of integrons in resistance of Campylobacter (especially at the molecular level) are discussed, as well as the mechanisms of resistance to β-lactam antibiotics, sulphonamides and trimethoprim. Multiple drug resistance is an increasing problem for treatment of campylobacter infections and emergence of resistant strains and resistance are important One Health issues.Ema AleksićBiljana Miljković-SelimovićZoran TamburNikola AleksićNikola AleksićVladimir BiočaninStevan AvramovStevan AvramovFrontiers Media S.A.articlecampylobacterantibiotic resistancemechanisms of resistancebacterial enterocolitissignificance of resistant strainsMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
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campylobacter antibiotic resistance mechanisms of resistance bacterial enterocolitis significance of resistant strains Medicine (General) R5-920 |
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campylobacter antibiotic resistance mechanisms of resistance bacterial enterocolitis significance of resistant strains Medicine (General) R5-920 Ema Aleksić Biljana Miljković-Selimović Zoran Tambur Nikola Aleksić Nikola Aleksić Vladimir Biočanin Stevan Avramov Stevan Avramov Resistance to Antibiotics in Thermophilic Campylobacters |
description |
Campylobacter jejuni (C. jejuni) is one of the most frequent causes of bacterial enterocolitis globally. The disease in human is usually self-limiting, but when complications arise antibiotic therapy is required at a time when resistance to antibiotics is increasing worldwide. Mechanisms of antibiotic resistance in bacteria are diverse depending on antibiotic type and usage and include: enzymatic destruction or drug inactivation; alteration of the target enzyme; alteration of cell membrane permeability; alteration of ribosome structure and alteration of the metabolic pathway(s). Resistance of Campylobacter spp. to antibiotics, especially fluoroquinolones is now a major public health problem in developed and developing countries. In this review the mechanisms of resistance to fluoroquinolones, macrolides, tetracycline, aminoglycoside and the role of integrons in resistance of Campylobacter (especially at the molecular level) are discussed, as well as the mechanisms of resistance to β-lactam antibiotics, sulphonamides and trimethoprim. Multiple drug resistance is an increasing problem for treatment of campylobacter infections and emergence of resistant strains and resistance are important One Health issues. |
format |
article |
author |
Ema Aleksić Biljana Miljković-Selimović Zoran Tambur Nikola Aleksić Nikola Aleksić Vladimir Biočanin Stevan Avramov Stevan Avramov |
author_facet |
Ema Aleksić Biljana Miljković-Selimović Zoran Tambur Nikola Aleksić Nikola Aleksić Vladimir Biočanin Stevan Avramov Stevan Avramov |
author_sort |
Ema Aleksić |
title |
Resistance to Antibiotics in Thermophilic Campylobacters |
title_short |
Resistance to Antibiotics in Thermophilic Campylobacters |
title_full |
Resistance to Antibiotics in Thermophilic Campylobacters |
title_fullStr |
Resistance to Antibiotics in Thermophilic Campylobacters |
title_full_unstemmed |
Resistance to Antibiotics in Thermophilic Campylobacters |
title_sort |
resistance to antibiotics in thermophilic campylobacters |
publisher |
Frontiers Media S.A. |
publishDate |
2021 |
url |
https://doaj.org/article/aee82740ad694eb1ad0633d1b7959be7 |
work_keys_str_mv |
AT emaaleksic resistancetoantibioticsinthermophiliccampylobacters AT biljanamiljkovicselimovic resistancetoantibioticsinthermophiliccampylobacters AT zorantambur resistancetoantibioticsinthermophiliccampylobacters AT nikolaaleksic resistancetoantibioticsinthermophiliccampylobacters AT nikolaaleksic resistancetoantibioticsinthermophiliccampylobacters AT vladimirbiocanin resistancetoantibioticsinthermophiliccampylobacters AT stevanavramov resistancetoantibioticsinthermophiliccampylobacters AT stevanavramov resistancetoantibioticsinthermophiliccampylobacters |
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1718439429754847232 |