Addition of a novel, protective family history category allows better profiling of cardiovascular risk and atherosclerotic burden in the general population. The Asklepios Study.

<h4>Objectives</h4>Whereas the importance of family history (FH) is widely recognized in cardiovascular risk assessment, its full potential could be underutilized, when applied with its current simple guidelines-based definition (cFH): presence of premature cardiovascular disease (CVD) i...

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Autores principales:	Caroline M Van daele, Tim De Meyer, Marc L De Buyzere, Thierry C Gillebert, Simon L I J Denil, Sofie Bekaert, Julio A Chirinos, Patrick Segers, Guy G De Backer, Dirk De Bacquer, Ernst R Rietzschel, Asklepios Investigators
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aeeaf38d494849048eb912fa299fa251
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spelling	oai:doaj.org-article:aeeaf38d494849048eb912fa299fa2512021-11-18T07:47:00ZAddition of a novel, protective family history category allows better profiling of cardiovascular risk and atherosclerotic burden in the general population. The Asklepios Study.1932-620310.1371/journal.pone.0063185https://doaj.org/article/aeeaf38d494849048eb912fa299fa2512013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23658806/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>Whereas the importance of family history (FH) is widely recognized in cardiovascular risk assessment, its full potential could be underutilized, when applied with its current simple guidelines-based definition (cFH): presence of premature cardiovascular disease (CVD) in a first-degree relative. We tested the added value of a new, extended family history definition (eFH), also taking into account later onset of disease, second-degree relatives and number of affected relatives, on profiling cardiovascular risk and atherosclerotic burden in the general population.<h4>Design</h4>Longitudinal population study.<h4>Setting</h4>Random, representative population sample from Erpe-Mere and Nieuwerkerken (Belgium, primary care).<h4>Subjects</h4>2524 male/female volunteers, aged 35-55 years, free from overt CVD.<h4>Main outcome measures</h4>Subjects were extensively phenotyped including presence of atherosclerosis (ultrasound) and a newly developed FH questionnaire (4 generations).<h4>Results</h4>Compared to cFH, eFH was superior in predicting an adverse risk profile (glycemic state, elevated blood pressure, lipid abnormalities, presence of metabolic syndrome components) and presence of atherosclerosis (all age & sex-adjusted p<0.05). Unlike cFH, eFH remained a significant predictor of subclinical atherosclerosis after adjusting for confounders. Most relations with eFH were not graded but showed clear informational breakpoints, with absence of CVD (including late onset) in any first-degree relative being a negative predictor of atherosclerosis, and a particularly interesting phenotype for further study.<h4>Conclusions</h4>A novel, extended FH definition is superior to the conventional definition in profiling cardiovascular risk and atherosclerotic burden in the general population. There remain clear opportunities to refine and increase the performance and informational content of this simple, readily-available inexpensive tool.Caroline M Van daeleTim De MeyerMarc L De BuyzereThierry C GillebertSimon L I J DenilSofie BekaertJulio A ChirinosPatrick SegersGuy G De BackerDirk De BacquerErnst R RietzschelAsklepios InvestigatorsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e63185 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caroline M Van daele Tim De Meyer Marc L De Buyzere Thierry C Gillebert Simon L I J Denil Sofie Bekaert Julio A Chirinos Patrick Segers Guy G De Backer Dirk De Bacquer Ernst R Rietzschel Asklepios Investigators Addition of a novel, protective family history category allows better profiling of cardiovascular risk and atherosclerotic burden in the general population. The Asklepios Study.
description	<h4>Objectives</h4>Whereas the importance of family history (FH) is widely recognized in cardiovascular risk assessment, its full potential could be underutilized, when applied with its current simple guidelines-based definition (cFH): presence of premature cardiovascular disease (CVD) in a first-degree relative. We tested the added value of a new, extended family history definition (eFH), also taking into account later onset of disease, second-degree relatives and number of affected relatives, on profiling cardiovascular risk and atherosclerotic burden in the general population.<h4>Design</h4>Longitudinal population study.<h4>Setting</h4>Random, representative population sample from Erpe-Mere and Nieuwerkerken (Belgium, primary care).<h4>Subjects</h4>2524 male/female volunteers, aged 35-55 years, free from overt CVD.<h4>Main outcome measures</h4>Subjects were extensively phenotyped including presence of atherosclerosis (ultrasound) and a newly developed FH questionnaire (4 generations).<h4>Results</h4>Compared to cFH, eFH was superior in predicting an adverse risk profile (glycemic state, elevated blood pressure, lipid abnormalities, presence of metabolic syndrome components) and presence of atherosclerosis (all age & sex-adjusted p<0.05). Unlike cFH, eFH remained a significant predictor of subclinical atherosclerosis after adjusting for confounders. Most relations with eFH were not graded but showed clear informational breakpoints, with absence of CVD (including late onset) in any first-degree relative being a negative predictor of atherosclerosis, and a particularly interesting phenotype for further study.<h4>Conclusions</h4>A novel, extended FH definition is superior to the conventional definition in profiling cardiovascular risk and atherosclerotic burden in the general population. There remain clear opportunities to refine and increase the performance and informational content of this simple, readily-available inexpensive tool.
format	article
author	Caroline M Van daele Tim De Meyer Marc L De Buyzere Thierry C Gillebert Simon L I J Denil Sofie Bekaert Julio A Chirinos Patrick Segers Guy G De Backer Dirk De Bacquer Ernst R Rietzschel Asklepios Investigators
author_facet	Caroline M Van daele Tim De Meyer Marc L De Buyzere Thierry C Gillebert Simon L I J Denil Sofie Bekaert Julio A Chirinos Patrick Segers Guy G De Backer Dirk De Bacquer Ernst R Rietzschel Asklepios Investigators
author_sort	Caroline M Van daele
title	Addition of a novel, protective family history category allows better profiling of cardiovascular risk and atherosclerotic burden in the general population. The Asklepios Study.
title_short	Addition of a novel, protective family history category allows better profiling of cardiovascular risk and atherosclerotic burden in the general population. The Asklepios Study.
title_full	Addition of a novel, protective family history category allows better profiling of cardiovascular risk and atherosclerotic burden in the general population. The Asklepios Study.
title_fullStr	Addition of a novel, protective family history category allows better profiling of cardiovascular risk and atherosclerotic burden in the general population. The Asklepios Study.
title_full_unstemmed	Addition of a novel, protective family history category allows better profiling of cardiovascular risk and atherosclerotic burden in the general population. The Asklepios Study.
title_sort	addition of a novel, protective family history category allows better profiling of cardiovascular risk and atherosclerotic burden in the general population. the asklepios study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/aeeaf38d494849048eb912fa299fa251
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Addition of a novel, protective family history category allows better profiling of cardiovascular risk and atherosclerotic burden in the general population. The Asklepios Study.

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