Diagnosis of fusion genes using targeted RNA sequencing

Rapid and accurate detection of fusion genes is important in cancer diagnostics. Here, the authors demonstrate that targeted RNA sequencing provides fast, sensitive and quantitative gene fusion detection and overcomes the limitations of approaches currently in clinical use.

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Autores principales:	Erin E. Heyer, Ira W. Deveson, Danson Wooi, Christina I. Selinger, Ruth J. Lyons, Vanessa M. Hayes, Sandra A. O’Toole, Mandy L. Ballinger, Devinder Gill, David M. Thomas, Tim R. Mercer, James Blackburn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aeee7920b057490a96c8d9d9d1354b59
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spelling	oai:doaj.org-article:aeee7920b057490a96c8d9d9d1354b592021-12-02T16:51:00ZDiagnosis of fusion genes using targeted RNA sequencing10.1038/s41467-019-09374-92041-1723https://doaj.org/article/aeee7920b057490a96c8d9d9d1354b592019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09374-9https://doaj.org/toc/2041-1723Rapid and accurate detection of fusion genes is important in cancer diagnostics. Here, the authors demonstrate that targeted RNA sequencing provides fast, sensitive and quantitative gene fusion detection and overcomes the limitations of approaches currently in clinical use.Erin E. HeyerIra W. DevesonDanson WooiChristina I. SelingerRuth J. LyonsVanessa M. HayesSandra A. O’TooleMandy L. BallingerDevinder GillDavid M. ThomasTim R. MercerJames BlackburnNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erin E. Heyer Ira W. Deveson Danson Wooi Christina I. Selinger Ruth J. Lyons Vanessa M. Hayes Sandra A. O’Toole Mandy L. Ballinger Devinder Gill David M. Thomas Tim R. Mercer James Blackburn Diagnosis of fusion genes using targeted RNA sequencing
description	Rapid and accurate detection of fusion genes is important in cancer diagnostics. Here, the authors demonstrate that targeted RNA sequencing provides fast, sensitive and quantitative gene fusion detection and overcomes the limitations of approaches currently in clinical use.
format	article
author	Erin E. Heyer Ira W. Deveson Danson Wooi Christina I. Selinger Ruth J. Lyons Vanessa M. Hayes Sandra A. O’Toole Mandy L. Ballinger Devinder Gill David M. Thomas Tim R. Mercer James Blackburn
author_facet	Erin E. Heyer Ira W. Deveson Danson Wooi Christina I. Selinger Ruth J. Lyons Vanessa M. Hayes Sandra A. O’Toole Mandy L. Ballinger Devinder Gill David M. Thomas Tim R. Mercer James Blackburn
author_sort	Erin E. Heyer
title	Diagnosis of fusion genes using targeted RNA sequencing
title_short	Diagnosis of fusion genes using targeted RNA sequencing
title_full	Diagnosis of fusion genes using targeted RNA sequencing
title_fullStr	Diagnosis of fusion genes using targeted RNA sequencing
title_full_unstemmed	Diagnosis of fusion genes using targeted RNA sequencing
title_sort	diagnosis of fusion genes using targeted rna sequencing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/aeee7920b057490a96c8d9d9d1354b59
work_keys_str_mv	AT erineheyer diagnosisoffusiongenesusingtargetedrnasequencing AT irawdeveson diagnosisoffusiongenesusingtargetedrnasequencing AT dansonwooi diagnosisoffusiongenesusingtargetedrnasequencing AT christinaiselinger diagnosisoffusiongenesusingtargetedrnasequencing AT ruthjlyons diagnosisoffusiongenesusingtargetedrnasequencing AT vanessamhayes diagnosisoffusiongenesusingtargetedrnasequencing AT sandraaotoole diagnosisoffusiongenesusingtargetedrnasequencing AT mandylballinger diagnosisoffusiongenesusingtargetedrnasequencing AT devindergill diagnosisoffusiongenesusingtargetedrnasequencing AT davidmthomas diagnosisoffusiongenesusingtargetedrnasequencing AT timrmercer diagnosisoffusiongenesusingtargetedrnasequencing AT jamesblackburn diagnosisoffusiongenesusingtargetedrnasequencing
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Diagnosis of fusion genes using targeted RNA sequencing

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