Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β.

Bisphenol-A (BPA) is a widespread endocrine-disrupting chemical (EDC) used as the base compound in the manufacture of polycarbonate plastics. It alters pancreatic β-cell function and can be considered a risk factor for type 2 diabetes in rodents. Here we used ERβ-/- mice to study whether ERβ is invo...

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Autores principales:	Sergi Soriano, Paloma Alonso-Magdalena, Marta García-Arévalo, Anna Novials, Sarheed J Muhammed, Albert Salehi, Jan-Ake Gustafsson, Ivan Quesada, Angel Nadal
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aeeebe0be17f439882d1e2539c0e31c4
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spelling	oai:doaj.org-article:aeeebe0be17f439882d1e2539c0e31c42021-11-18T07:28:40ZRapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β.1932-620310.1371/journal.pone.0031109https://doaj.org/article/aeeebe0be17f439882d1e2539c0e31c42012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22347437/?tool=EBIhttps://doaj.org/toc/1932-6203Bisphenol-A (BPA) is a widespread endocrine-disrupting chemical (EDC) used as the base compound in the manufacture of polycarbonate plastics. It alters pancreatic β-cell function and can be considered a risk factor for type 2 diabetes in rodents. Here we used ERβ-/- mice to study whether ERβ is involved in the rapid regulation of K(ATP) channel activity, calcium signals and insulin release elicited by environmentally relevant doses of BPA (1 nM). We also investigated these effects of BPA in β-cells and whole islets of Langerhans from humans. 1 nM BPA rapidly decreased K(ATP) channel activity, increased glucose-induced [Ca(2+)](i) signals and insulin release in β-cells from WT mice but not in cells from ERβ-/- mice. The rapid reduction in the K(ATP) channel activity and the insulinotropic effect was seen in human cells and islets. BPA actions were stronger in human islets compared to mouse islets when the same BPA concentration was used. Our findings suggest that BPA behaves as a strong estrogen via nuclear ERβ and indicate that results obtained with BPA in mouse β-cells may be extrapolated to humans. This supports that BPA should be considered as a risk factor for metabolic disorders in humans.Sergi SorianoPaloma Alonso-MagdalenaMarta García-ArévaloAnna NovialsSarheed J MuhammedAlbert SalehiJan-Ake GustafssonIvan QuesadaAngel NadalPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e31109 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sergi Soriano Paloma Alonso-Magdalena Marta García-Arévalo Anna Novials Sarheed J Muhammed Albert Salehi Jan-Ake Gustafsson Ivan Quesada Angel Nadal Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β.
description	Bisphenol-A (BPA) is a widespread endocrine-disrupting chemical (EDC) used as the base compound in the manufacture of polycarbonate plastics. It alters pancreatic β-cell function and can be considered a risk factor for type 2 diabetes in rodents. Here we used ERβ-/- mice to study whether ERβ is involved in the rapid regulation of K(ATP) channel activity, calcium signals and insulin release elicited by environmentally relevant doses of BPA (1 nM). We also investigated these effects of BPA in β-cells and whole islets of Langerhans from humans. 1 nM BPA rapidly decreased K(ATP) channel activity, increased glucose-induced [Ca(2+)](i) signals and insulin release in β-cells from WT mice but not in cells from ERβ-/- mice. The rapid reduction in the K(ATP) channel activity and the insulinotropic effect was seen in human cells and islets. BPA actions were stronger in human islets compared to mouse islets when the same BPA concentration was used. Our findings suggest that BPA behaves as a strong estrogen via nuclear ERβ and indicate that results obtained with BPA in mouse β-cells may be extrapolated to humans. This supports that BPA should be considered as a risk factor for metabolic disorders in humans.
format	article
author	Sergi Soriano Paloma Alonso-Magdalena Marta García-Arévalo Anna Novials Sarheed J Muhammed Albert Salehi Jan-Ake Gustafsson Ivan Quesada Angel Nadal
author_facet	Sergi Soriano Paloma Alonso-Magdalena Marta García-Arévalo Anna Novials Sarheed J Muhammed Albert Salehi Jan-Ake Gustafsson Ivan Quesada Angel Nadal
author_sort	Sergi Soriano
title	Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β.
title_short	Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β.
title_full	Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β.
title_fullStr	Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β.
title_full_unstemmed	Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β.
title_sort	rapid insulinotropic action of low doses of bisphenol-a on mouse and human islets of langerhans: role of estrogen receptor β.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/aeeebe0be17f439882d1e2539c0e31c4
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Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β.

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