Impact of chronic schistosomiasis and HBV/HCV co-infection on the liver: current perspectives

Hanan Hassan Omar Clinical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia, EgyptCorrespondence: Hanan Hassan OmarClinical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia 41111, EgyptTel +20 109 362 7403Email hananhassan1978@gmail.comAbstract: Sc...

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Autor principal:	Omar HH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	schistosomiasis co-infection HBV;HCV Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/aeef5993a48b43849df6e6ab51a9b174
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spelling	oai:doaj.org-article:aeef5993a48b43849df6e6ab51a9b1742021-12-02T08:27:53ZImpact of chronic schistosomiasis and HBV/HCV co-infection on the liver: current perspectives1179-1535https://doaj.org/article/aeef5993a48b43849df6e6ab51a9b1742019-09-01T00:00:00Zhttps://www.dovepress.com/impact-of-chronic-schistosomiasis-and-hbvhcv-co-infection-on-the-liver-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535Hanan Hassan Omar Clinical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia, EgyptCorrespondence: Hanan Hassan OmarClinical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia 41111, EgyptTel +20 109 362 7403Email hananhassan1978@gmail.comAbstract: Schistosomiasis is a public health problem in many countries. Its prevalence is increasing annually; the current infection rate is one in 30 individuals. The WHO reported that at least 206.4 million people all over the world required preventive treatments for schistosomiasis in 2016. Chronic schistosomiasis, hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infection are common in countries where schistosomiasis is endemic. The effects of the hepatotropic virus co-infection may modify the Th2-dominated granulomatous phase of schistosomal infection. These viruses induce a strong-specific T cell response, with infiltration of large numbers of specific interferon-γ-producing CD8+ cells into the liver. The outcome of liver diseases depends on the underlying causes, host immune response and concomitant infections. Co-infection of schistosomiasis with HBV/HCV infection causes advanced liver disease and worsens the outcome, especially with higher viral load titers, which increase the mortality rate through an increased incidence of liver cirrhosis and hepatocellular carcinoma. The exposure risk for HBV in patients with HCV and schistosomiasis was two and half times greater than that in CHC patients without schistosomiasis. Finally, chronic schistosomiasis and HBV/HCV co-infection have serious effects on liver pathology. Co-infection accelerates the progression of liver disease and leads to advanced liver diseases and liver failure.Keywords: schistosomiasis, co-infection, HBV, HCVOmar HHDove Medical Pressarticleschistosomiasisco-infectionHBV;HCVDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol Volume 11, Pp 131-136 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	schistosomiasis co-infection HBV;HCV Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	schistosomiasis co-infection HBV;HCV Diseases of the digestive system. Gastroenterology RC799-869 Omar HH Impact of chronic schistosomiasis and HBV/HCV co-infection on the liver: current perspectives
description	Hanan Hassan Omar Clinical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia, EgyptCorrespondence: Hanan Hassan OmarClinical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia 41111, EgyptTel +20 109 362 7403Email hananhassan1978@gmail.comAbstract: Schistosomiasis is a public health problem in many countries. Its prevalence is increasing annually; the current infection rate is one in 30 individuals. The WHO reported that at least 206.4 million people all over the world required preventive treatments for schistosomiasis in 2016. Chronic schistosomiasis, hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infection are common in countries where schistosomiasis is endemic. The effects of the hepatotropic virus co-infection may modify the Th2-dominated granulomatous phase of schistosomal infection. These viruses induce a strong-specific T cell response, with infiltration of large numbers of specific interferon-γ-producing CD8+ cells into the liver. The outcome of liver diseases depends on the underlying causes, host immune response and concomitant infections. Co-infection of schistosomiasis with HBV/HCV infection causes advanced liver disease and worsens the outcome, especially with higher viral load titers, which increase the mortality rate through an increased incidence of liver cirrhosis and hepatocellular carcinoma. The exposure risk for HBV in patients with HCV and schistosomiasis was two and half times greater than that in CHC patients without schistosomiasis. Finally, chronic schistosomiasis and HBV/HCV co-infection have serious effects on liver pathology. Co-infection accelerates the progression of liver disease and leads to advanced liver diseases and liver failure.Keywords: schistosomiasis, co-infection, HBV, HCV
format	article
author	Omar HH
author_facet	Omar HH
author_sort	Omar HH
title	Impact of chronic schistosomiasis and HBV/HCV co-infection on the liver: current perspectives
title_short	Impact of chronic schistosomiasis and HBV/HCV co-infection on the liver: current perspectives
title_full	Impact of chronic schistosomiasis and HBV/HCV co-infection on the liver: current perspectives
title_fullStr	Impact of chronic schistosomiasis and HBV/HCV co-infection on the liver: current perspectives
title_full_unstemmed	Impact of chronic schistosomiasis and HBV/HCV co-infection on the liver: current perspectives
title_sort	impact of chronic schistosomiasis and hbv/hcv co-infection on the liver: current perspectives
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/aeef5993a48b43849df6e6ab51a9b174
work_keys_str_mv	AT omarhh impactofchronicschistosomiasisandhbvhcvcoinfectiononthelivercurrentperspectives
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Impact of chronic schistosomiasis and HBV/HCV co-infection on the liver: current perspectives

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