The Cooperative Re-Engagement Controlled trial (CoRECT): A randomised trial to assess a collaborative data to care model to improve HIV care continuum outcomes

Background: Persons with HIV (PWH), aware of their HIV infection but not in care account for an estimated 42.6% of HIV transmissions in the United States. Health departments and clinics implemented a collaborative data-to-care strategy to identify persons newly out-of-care with the objective of incr...

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Autores principales:	Robyn Neblett Fanfair, George Khalil, Tiffany Williams, Kathleen Brady, Alfred DeMaria, Merceditas Villanueva, Liisa M. Randall, Heidi Jenkins, Frederick L. Altice, Nasima Camp, Crystal Lucas, Marianne Buchelli, Taraz Samandari, Paul J. Weidle
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Randomized Trial HIV/AIDS Data to Care Health Department Interventions Re-engagement in care Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/aef30e9710124346a1dbcd22747b51d4
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spelling	oai:doaj.org-article:aef30e9710124346a1dbcd22747b51d42021-11-12T04:50:25ZThe Cooperative Re-Engagement Controlled trial (CoRECT): A randomised trial to assess a collaborative data to care model to improve HIV care continuum outcomes2667-193X10.1016/j.lana.2021.100057https://doaj.org/article/aef30e9710124346a1dbcd22747b51d42021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667193X21000491https://doaj.org/toc/2667-193XBackground: Persons with HIV (PWH), aware of their HIV infection but not in care account for an estimated 42.6% of HIV transmissions in the United States. Health departments and clinics implemented a collaborative data-to-care strategy to identify persons newly out-of-care with the objective of increasing re-engagement, retention in medical care, and viral load suppression Methods: A multi-site, prospective randomised trial was conducted to identify newly out-of-care PWH using surveillance and clinic data in Connecticut (CT), Massachusetts (MA) and Philadelphia (PHL). All out-of-care participants were randomised to receive standard of care or an active public health intervention. Re-engagement in care was defined as having a documented CD4 count and/or HIV viral load within 90 days of randomization. Retention was defined as having at least two CD4 count and/or HIV viral load results ≥ 3 months apart within 12 months of randomization, and viral load suppression as having a viral load < 200 copies/ml within 12 months of randomization. Findings: Between August 2016 and July 2018, 1893 out-of-care participants were randomised from CT (N = 654), MA (N = 630), and PHL (N = 609). Participants were male (69.5%), non-Hispanic Black (48.3%) and men who have sex with men (38.8%). Re-engagement within 90 days was significantly higher for the intervention group overall and in all three jurisdictions (All sites: 54.9% vs 42.1%, p < 0.0001; CT: 51.2% vs 41.9%, p = 0.02; MA: 52.7% vs 44.1%, p = 0.03; PHL 61.2% vs 40.3%, p < 0.0001). Retention in care over 12 months improved overall (p = 0.04). Median time to viral suppression was reduced overall (p = 0.0006); CT (p = 0.32), MA (p = 0.02) and PHL (p < 0.0001). Interpretation: This trial showed that a collaborative, data-to-care strategy, and active public health intervention led by health departments significantly increases the proportion of PWH re-engaged in HIV care and may improve retention in care and decrease time to viral suppression.Robyn Neblett FanfairGeorge KhalilTiffany WilliamsKathleen BradyAlfred DeMariaMerceditas VillanuevaLiisa M. RandallHeidi JenkinsFrederick L. AlticeNasima CampCrystal LucasMarianne BuchelliTaraz SamandariPaul J. WeidleElsevierarticleRandomized TrialHIV/AIDSData to CareHealth Department InterventionsRe-engagement in carePublic aspects of medicineRA1-1270ENThe Lancet Regional Health. Americas, Vol 3, Iss , Pp 100057- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Randomized Trial HIV/AIDS Data to Care Health Department Interventions Re-engagement in care Public aspects of medicine RA1-1270
spellingShingle	Randomized Trial HIV/AIDS Data to Care Health Department Interventions Re-engagement in care Public aspects of medicine RA1-1270 Robyn Neblett Fanfair George Khalil Tiffany Williams Kathleen Brady Alfred DeMaria Merceditas Villanueva Liisa M. Randall Heidi Jenkins Frederick L. Altice Nasima Camp Crystal Lucas Marianne Buchelli Taraz Samandari Paul J. Weidle The Cooperative Re-Engagement Controlled trial (CoRECT): A randomised trial to assess a collaborative data to care model to improve HIV care continuum outcomes
description	Background: Persons with HIV (PWH), aware of their HIV infection but not in care account for an estimated 42.6% of HIV transmissions in the United States. Health departments and clinics implemented a collaborative data-to-care strategy to identify persons newly out-of-care with the objective of increasing re-engagement, retention in medical care, and viral load suppression Methods: A multi-site, prospective randomised trial was conducted to identify newly out-of-care PWH using surveillance and clinic data in Connecticut (CT), Massachusetts (MA) and Philadelphia (PHL). All out-of-care participants were randomised to receive standard of care or an active public health intervention. Re-engagement in care was defined as having a documented CD4 count and/or HIV viral load within 90 days of randomization. Retention was defined as having at least two CD4 count and/or HIV viral load results ≥ 3 months apart within 12 months of randomization, and viral load suppression as having a viral load < 200 copies/ml within 12 months of randomization. Findings: Between August 2016 and July 2018, 1893 out-of-care participants were randomised from CT (N = 654), MA (N = 630), and PHL (N = 609). Participants were male (69.5%), non-Hispanic Black (48.3%) and men who have sex with men (38.8%). Re-engagement within 90 days was significantly higher for the intervention group overall and in all three jurisdictions (All sites: 54.9% vs 42.1%, p < 0.0001; CT: 51.2% vs 41.9%, p = 0.02; MA: 52.7% vs 44.1%, p = 0.03; PHL 61.2% vs 40.3%, p < 0.0001). Retention in care over 12 months improved overall (p = 0.04). Median time to viral suppression was reduced overall (p = 0.0006); CT (p = 0.32), MA (p = 0.02) and PHL (p < 0.0001). Interpretation: This trial showed that a collaborative, data-to-care strategy, and active public health intervention led by health departments significantly increases the proportion of PWH re-engaged in HIV care and may improve retention in care and decrease time to viral suppression.
format	article
author	Robyn Neblett Fanfair George Khalil Tiffany Williams Kathleen Brady Alfred DeMaria Merceditas Villanueva Liisa M. Randall Heidi Jenkins Frederick L. Altice Nasima Camp Crystal Lucas Marianne Buchelli Taraz Samandari Paul J. Weidle
author_facet	Robyn Neblett Fanfair George Khalil Tiffany Williams Kathleen Brady Alfred DeMaria Merceditas Villanueva Liisa M. Randall Heidi Jenkins Frederick L. Altice Nasima Camp Crystal Lucas Marianne Buchelli Taraz Samandari Paul J. Weidle
author_sort	Robyn Neblett Fanfair
title	The Cooperative Re-Engagement Controlled trial (CoRECT): A randomised trial to assess a collaborative data to care model to improve HIV care continuum outcomes
title_short	The Cooperative Re-Engagement Controlled trial (CoRECT): A randomised trial to assess a collaborative data to care model to improve HIV care continuum outcomes
title_full	The Cooperative Re-Engagement Controlled trial (CoRECT): A randomised trial to assess a collaborative data to care model to improve HIV care continuum outcomes
title_fullStr	The Cooperative Re-Engagement Controlled trial (CoRECT): A randomised trial to assess a collaborative data to care model to improve HIV care continuum outcomes
title_full_unstemmed	The Cooperative Re-Engagement Controlled trial (CoRECT): A randomised trial to assess a collaborative data to care model to improve HIV care continuum outcomes
title_sort	cooperative re-engagement controlled trial (corect): a randomised trial to assess a collaborative data to care model to improve hiv care continuum outcomes
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/aef30e9710124346a1dbcd22747b51d4
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The Cooperative Re-Engagement Controlled trial (CoRECT): A randomised trial to assess a collaborative data to care model to improve HIV care continuum outcomes

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