Sox17 is required for endothelial regeneration following inflammation-induced vascular injury

Endothelial cell regeneration is essential for blood vessels to recover from inflammation-induced injury. Here Liu et al. show that the transcription factor Sox17 is required for endothelial regeneration following endotoxemia, and that delivery of a transgene expressing Sox17 to lung endothelial cel...

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Autores principales:	Menglin Liu, Lianghui Zhang, Glenn Marsboom, Ankit Jambusaria, Shiqin Xiong, Peter T. Toth, Elizaveta V. Benevolenskaya, Jalees Rehman, Asrar B. Malik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aef5d536288346a9aed9848b8a1f6268
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spelling	oai:doaj.org-article:aef5d536288346a9aed9848b8a1f62682021-12-02T16:58:05ZSox17 is required for endothelial regeneration following inflammation-induced vascular injury10.1038/s41467-019-10134-y2041-1723https://doaj.org/article/aef5d536288346a9aed9848b8a1f62682019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10134-yhttps://doaj.org/toc/2041-1723Endothelial cell regeneration is essential for blood vessels to recover from inflammation-induced injury. Here Liu et al. show that the transcription factor Sox17 is required for endothelial regeneration following endotoxemia, and that delivery of a transgene expressing Sox17 to lung endothelial cells enhances recovery after injury.Menglin LiuLianghui ZhangGlenn MarsboomAnkit JambusariaShiqin XiongPeter T. TothElizaveta V. BenevolenskayaJalees RehmanAsrar B. MalikNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Menglin Liu Lianghui Zhang Glenn Marsboom Ankit Jambusaria Shiqin Xiong Peter T. Toth Elizaveta V. Benevolenskaya Jalees Rehman Asrar B. Malik Sox17 is required for endothelial regeneration following inflammation-induced vascular injury
description	Endothelial cell regeneration is essential for blood vessels to recover from inflammation-induced injury. Here Liu et al. show that the transcription factor Sox17 is required for endothelial regeneration following endotoxemia, and that delivery of a transgene expressing Sox17 to lung endothelial cells enhances recovery after injury.
format	article
author	Menglin Liu Lianghui Zhang Glenn Marsboom Ankit Jambusaria Shiqin Xiong Peter T. Toth Elizaveta V. Benevolenskaya Jalees Rehman Asrar B. Malik
author_facet	Menglin Liu Lianghui Zhang Glenn Marsboom Ankit Jambusaria Shiqin Xiong Peter T. Toth Elizaveta V. Benevolenskaya Jalees Rehman Asrar B. Malik
author_sort	Menglin Liu
title	Sox17 is required for endothelial regeneration following inflammation-induced vascular injury
title_short	Sox17 is required for endothelial regeneration following inflammation-induced vascular injury
title_full	Sox17 is required for endothelial regeneration following inflammation-induced vascular injury
title_fullStr	Sox17 is required for endothelial regeneration following inflammation-induced vascular injury
title_full_unstemmed	Sox17 is required for endothelial regeneration following inflammation-induced vascular injury
title_sort	sox17 is required for endothelial regeneration following inflammation-induced vascular injury
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/aef5d536288346a9aed9848b8a1f6268
work_keys_str_mv	AT menglinliu sox17isrequiredforendothelialregenerationfollowinginflammationinducedvascularinjury AT lianghuizhang sox17isrequiredforendothelialregenerationfollowinginflammationinducedvascularinjury AT glennmarsboom sox17isrequiredforendothelialregenerationfollowinginflammationinducedvascularinjury AT ankitjambusaria sox17isrequiredforendothelialregenerationfollowinginflammationinducedvascularinjury AT shiqinxiong sox17isrequiredforendothelialregenerationfollowinginflammationinducedvascularinjury AT peterttoth sox17isrequiredforendothelialregenerationfollowinginflammationinducedvascularinjury AT elizavetavbenevolenskaya sox17isrequiredforendothelialregenerationfollowinginflammationinducedvascularinjury AT jaleesrehman sox17isrequiredforendothelialregenerationfollowinginflammationinducedvascularinjury AT asrarbmalik sox17isrequiredforendothelialregenerationfollowinginflammationinducedvascularinjury
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Sox17 is required for endothelial regeneration following inflammation-induced vascular injury

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