The incidence trends of liver cirrhosis caused by nonalcoholic steatohepatitis via the GBD study 2017

Abstract Nonalcoholic steatohepatitis (NASH) has rapidly become the most common cause of chronic liver diseases. We aimed to explore the incidence and distribution characteristics of NASH by sex, region and sociodemographic index (SDI). We collected data, including sex and region, on NASH-related li...

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Autores principales:	Mimi Zhai, Zhide Liu, Jianhai Long, Qingxiang Zhou, Leping Yang, Qin Zhou, Sushun Liu, Yu Dai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aef9abade1d141af880105cdb3f3792f
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spelling	oai:doaj.org-article:aef9abade1d141af880105cdb3f3792f2021-12-02T15:54:13ZThe incidence trends of liver cirrhosis caused by nonalcoholic steatohepatitis via the GBD study 201710.1038/s41598-021-84577-z2045-2322https://doaj.org/article/aef9abade1d141af880105cdb3f3792f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84577-zhttps://doaj.org/toc/2045-2322Abstract Nonalcoholic steatohepatitis (NASH) has rapidly become the most common cause of chronic liver diseases. We aimed to explore the incidence and distribution characteristics of NASH by sex, region and sociodemographic index (SDI). We collected data, including sex and region, on NASH-related liver cirrhosis from the 2017 GBD study. The age-standardized incidence rates (ASRs) and estimated annual percentage changes (EAPCs) were used to estimate the incidence trend and distribution characteristics. Globally, the incidence of liver cirrhosis caused by NASH increased from 178,430 cases in 1990 to 367,780 cases in 2017, an increase of approximately 105.56%. The ASR of NASH increased by an average of 1.35% per year (95% CI 1.28–1.42). Meanwhile, large differences in the ASR and the EAPC were observed across regions. The middle-high SDI region had the highest increase among all five SDI regions, followed by middle SDI region. In addition, Eastern Europe, Andean Latin America and Central Asia showed a more significant growth trend of ASR. In contrast, the high SDI region demonstrated the slowest increasing trend of ASR, and the high-income Asia Pacific demonstrated a decreasing trend among the 21 regions. Liver cirrhosis has caused a huge and rising health burden in many countries and regions. In addition, with the growth of obesity, population and aging, NASH might replace viral hepatitis as the most important cause of liver cirrhosis in the near future. Therefore, appropriate interventions are needed in coming decades to realize early diagnosis and prevention of NASH-related liver cirrhosis.Mimi ZhaiZhide LiuJianhai LongQingxiang ZhouLeping YangQin ZhouSushun LiuYu DaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mimi Zhai Zhide Liu Jianhai Long Qingxiang Zhou Leping Yang Qin Zhou Sushun Liu Yu Dai The incidence trends of liver cirrhosis caused by nonalcoholic steatohepatitis via the GBD study 2017
description	Abstract Nonalcoholic steatohepatitis (NASH) has rapidly become the most common cause of chronic liver diseases. We aimed to explore the incidence and distribution characteristics of NASH by sex, region and sociodemographic index (SDI). We collected data, including sex and region, on NASH-related liver cirrhosis from the 2017 GBD study. The age-standardized incidence rates (ASRs) and estimated annual percentage changes (EAPCs) were used to estimate the incidence trend and distribution characteristics. Globally, the incidence of liver cirrhosis caused by NASH increased from 178,430 cases in 1990 to 367,780 cases in 2017, an increase of approximately 105.56%. The ASR of NASH increased by an average of 1.35% per year (95% CI 1.28–1.42). Meanwhile, large differences in the ASR and the EAPC were observed across regions. The middle-high SDI region had the highest increase among all five SDI regions, followed by middle SDI region. In addition, Eastern Europe, Andean Latin America and Central Asia showed a more significant growth trend of ASR. In contrast, the high SDI region demonstrated the slowest increasing trend of ASR, and the high-income Asia Pacific demonstrated a decreasing trend among the 21 regions. Liver cirrhosis has caused a huge and rising health burden in many countries and regions. In addition, with the growth of obesity, population and aging, NASH might replace viral hepatitis as the most important cause of liver cirrhosis in the near future. Therefore, appropriate interventions are needed in coming decades to realize early diagnosis and prevention of NASH-related liver cirrhosis.
format	article
author	Mimi Zhai Zhide Liu Jianhai Long Qingxiang Zhou Leping Yang Qin Zhou Sushun Liu Yu Dai
author_facet	Mimi Zhai Zhide Liu Jianhai Long Qingxiang Zhou Leping Yang Qin Zhou Sushun Liu Yu Dai
author_sort	Mimi Zhai
title	The incidence trends of liver cirrhosis caused by nonalcoholic steatohepatitis via the GBD study 2017
title_short	The incidence trends of liver cirrhosis caused by nonalcoholic steatohepatitis via the GBD study 2017
title_full	The incidence trends of liver cirrhosis caused by nonalcoholic steatohepatitis via the GBD study 2017
title_fullStr	The incidence trends of liver cirrhosis caused by nonalcoholic steatohepatitis via the GBD study 2017
title_full_unstemmed	The incidence trends of liver cirrhosis caused by nonalcoholic steatohepatitis via the GBD study 2017
title_sort	incidence trends of liver cirrhosis caused by nonalcoholic steatohepatitis via the gbd study 2017
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aef9abade1d141af880105cdb3f3792f
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The incidence trends of liver cirrhosis caused by nonalcoholic steatohepatitis via the GBD study 2017

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