Efficacy of an artificial tear emulsion in patients with dry eye associated with meibomian gland dysfunction

Christine W Sindt,1 Gary N Foulks2 1Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, IA, 2Kentucky Lions Eye Center, Department of Ophthalmology and Visual Science, University of Louisville, Louisville, KY, USA Objectives: The aim of the study rep...

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Autores principales:	Sindt CW, Foulks GN
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/af01a9218a2141e7bf8869e62273a707
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spelling	oai:doaj.org-article:af01a9218a2141e7bf8869e62273a7072021-12-02T07:33:55ZEfficacy of an artificial tear emulsion in patients with dry eye associated with meibomian gland dysfunction1177-54671177-5483https://doaj.org/article/af01a9218a2141e7bf8869e62273a7072013-08-01T00:00:00Zhttp://www.dovepress.com/efficacy-of-an-artificial-tear-emulsion-in-patients-with-dry-eye-assoc-a14172https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Christine W Sindt,1 Gary N Foulks2 1Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, IA, 2Kentucky Lions Eye Center, Department of Ophthalmology and Visual Science, University of Louisville, Louisville, KY, USA Objectives: The aim of the study reported here was to assess the efficacy of an artificial tear emulsion for the treatment of dry eye associated with meibomian gland dysfunction (MGD). Methods: At five clinics, patients completed a 1-week treatment with their habitual topical therapy and then a 4-week treatment with open-label study medication: Systane® Balance Lubricant Eye Drops (Alcon, Alcon Inc, Fort Worth, TX, USA). Subjective assessments included a preference survey, the Impact of Dry Eye in Everyday Life questionnaire, and the Work Productivity and Activity Impairment questionnaire. Objective assessments by unmasked investigators included visual acuity, meibomian gland expression and dropout, tear film breakup time, corneal staining, and dosing frequency. Results: At baseline, the 49 patients had mean meibomian gland expression grades and gland dropout that indicated mild to moderate MGD. Patients administered their habitual therapy 2.5 ± 1.3 times per day. After 4 weeks of study medication, the Impact of Dry Eye in Everyday Life questionnaire results indicated statistically and clinically significant improvements. Fewer than half of the participants were employed, limiting the usefulness of the Work Productivity and Activity Impairment questionnaire. Visual acuity remained statistically similar, while corneal staining and tear film breakup time improved significantly (P < 0.05) but modestly. The outcomes were achieved with 1.9 ± 1.1 doses per day of study medication, a significantly lower frequency than the habitual frequency (P < 0.001). The most common medication-related adverse event was blurred vision (3/49 patients, 6.1%). At study conclusion, 27/44 (61.4%) survey respondents preferred the study medication to their habitual therapy. Conclusion: The artificial tear emulsion was effective for treating the signs and symptoms of dry eye in MGD patients. Keywords: ophthalmic solutions, Work Productivity and Activity Impairment, Impact on Dry Eye in Everyday Life, MGD, tear film breakup time, corneal stainingSindt CWFoulks GNDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 1713-1722 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Sindt CW Foulks GN Efficacy of an artificial tear emulsion in patients with dry eye associated with meibomian gland dysfunction
description	Christine W Sindt,1 Gary N Foulks2 1Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, IA, 2Kentucky Lions Eye Center, Department of Ophthalmology and Visual Science, University of Louisville, Louisville, KY, USA Objectives: The aim of the study reported here was to assess the efficacy of an artificial tear emulsion for the treatment of dry eye associated with meibomian gland dysfunction (MGD). Methods: At five clinics, patients completed a 1-week treatment with their habitual topical therapy and then a 4-week treatment with open-label study medication: Systane® Balance Lubricant Eye Drops (Alcon, Alcon Inc, Fort Worth, TX, USA). Subjective assessments included a preference survey, the Impact of Dry Eye in Everyday Life questionnaire, and the Work Productivity and Activity Impairment questionnaire. Objective assessments by unmasked investigators included visual acuity, meibomian gland expression and dropout, tear film breakup time, corneal staining, and dosing frequency. Results: At baseline, the 49 patients had mean meibomian gland expression grades and gland dropout that indicated mild to moderate MGD. Patients administered their habitual therapy 2.5 ± 1.3 times per day. After 4 weeks of study medication, the Impact of Dry Eye in Everyday Life questionnaire results indicated statistically and clinically significant improvements. Fewer than half of the participants were employed, limiting the usefulness of the Work Productivity and Activity Impairment questionnaire. Visual acuity remained statistically similar, while corneal staining and tear film breakup time improved significantly (P < 0.05) but modestly. The outcomes were achieved with 1.9 ± 1.1 doses per day of study medication, a significantly lower frequency than the habitual frequency (P < 0.001). The most common medication-related adverse event was blurred vision (3/49 patients, 6.1%). At study conclusion, 27/44 (61.4%) survey respondents preferred the study medication to their habitual therapy. Conclusion: The artificial tear emulsion was effective for treating the signs and symptoms of dry eye in MGD patients. Keywords: ophthalmic solutions, Work Productivity and Activity Impairment, Impact on Dry Eye in Everyday Life, MGD, tear film breakup time, corneal staining
format	article
author	Sindt CW Foulks GN
author_facet	Sindt CW Foulks GN
author_sort	Sindt CW
title	Efficacy of an artificial tear emulsion in patients with dry eye associated with meibomian gland dysfunction
title_short	Efficacy of an artificial tear emulsion in patients with dry eye associated with meibomian gland dysfunction
title_full	Efficacy of an artificial tear emulsion in patients with dry eye associated with meibomian gland dysfunction
title_fullStr	Efficacy of an artificial tear emulsion in patients with dry eye associated with meibomian gland dysfunction
title_full_unstemmed	Efficacy of an artificial tear emulsion in patients with dry eye associated with meibomian gland dysfunction
title_sort	efficacy of an artificial tear emulsion in patients with dry eye associated with meibomian gland dysfunction
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/af01a9218a2141e7bf8869e62273a707
work_keys_str_mv	AT sindtcw efficacyofanartificialtearemulsioninpatientswithdryeyeassociatedwithmeibomianglanddysfunction AT foulksgn efficacyofanartificialtearemulsioninpatientswithdryeyeassociatedwithmeibomianglanddysfunction
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Efficacy of an artificial tear emulsion in patients with dry eye associated with meibomian gland dysfunction

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