Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway

Abstract SARS-CoV2 is a previously uncharacterized coronavirus and causative agent of the COVID-19 pandemic. The host response to SARS-CoV2 has not yet been fully delineated, hampering a precise approach to therapy. To address this, we carried out a comprehensive analysis of gene expression data fro...

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Autores principales:	Andrea R. Daamen, Prathyusha Bachali, Katherine A. Owen, Kathryn M. Kingsmore, Erika L. Hubbard, Adam C. Labonte, Robert Robl, Sneha Shrotri, Amrie C. Grammer, Peter E. Lipsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/af04a84c540243f9813b38aac1d0e6e6
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spelling	oai:doaj.org-article:af04a84c540243f9813b38aac1d0e6e62021-12-02T14:23:23ZComprehensive transcriptomic analysis of COVID-19 blood, lung, and airway10.1038/s41598-021-86002-x2045-2322https://doaj.org/article/af04a84c540243f9813b38aac1d0e6e62021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86002-xhttps://doaj.org/toc/2045-2322Abstract SARS-CoV2 is a previously uncharacterized coronavirus and causative agent of the COVID-19 pandemic. The host response to SARS-CoV2 has not yet been fully delineated, hampering a precise approach to therapy. To address this, we carried out a comprehensive analysis of gene expression data from the blood, lung, and airway of COVID-19 patients. Our results indicate that COVID-19 pathogenesis is driven by populations of myeloid-lineage cells with highly inflammatory but distinct transcriptional signatures in each compartment. The relative absence of cytotoxic cells in the lung suggests a model in which delayed clearance of the virus may permit exaggerated myeloid cell activation that contributes to disease pathogenesis by the production of inflammatory mediators. The gene expression profiles also identify potential therapeutic targets that could be modified with available drugs. The data suggest that transcriptomic profiling can provide an understanding of the pathogenesis of COVID-19 in individual patients.Andrea R. DaamenPrathyusha BachaliKatherine A. OwenKathryn M. KingsmoreErika L. HubbardAdam C. LabonteRobert RoblSneha ShrotriAmrie C. GrammerPeter E. LipskyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrea R. Daamen Prathyusha Bachali Katherine A. Owen Kathryn M. Kingsmore Erika L. Hubbard Adam C. Labonte Robert Robl Sneha Shrotri Amrie C. Grammer Peter E. Lipsky Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway
description	Abstract SARS-CoV2 is a previously uncharacterized coronavirus and causative agent of the COVID-19 pandemic. The host response to SARS-CoV2 has not yet been fully delineated, hampering a precise approach to therapy. To address this, we carried out a comprehensive analysis of gene expression data from the blood, lung, and airway of COVID-19 patients. Our results indicate that COVID-19 pathogenesis is driven by populations of myeloid-lineage cells with highly inflammatory but distinct transcriptional signatures in each compartment. The relative absence of cytotoxic cells in the lung suggests a model in which delayed clearance of the virus may permit exaggerated myeloid cell activation that contributes to disease pathogenesis by the production of inflammatory mediators. The gene expression profiles also identify potential therapeutic targets that could be modified with available drugs. The data suggest that transcriptomic profiling can provide an understanding of the pathogenesis of COVID-19 in individual patients.
format	article
author	Andrea R. Daamen Prathyusha Bachali Katherine A. Owen Kathryn M. Kingsmore Erika L. Hubbard Adam C. Labonte Robert Robl Sneha Shrotri Amrie C. Grammer Peter E. Lipsky
author_facet	Andrea R. Daamen Prathyusha Bachali Katherine A. Owen Kathryn M. Kingsmore Erika L. Hubbard Adam C. Labonte Robert Robl Sneha Shrotri Amrie C. Grammer Peter E. Lipsky
author_sort	Andrea R. Daamen
title	Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway
title_short	Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway
title_full	Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway
title_fullStr	Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway
title_full_unstemmed	Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway
title_sort	comprehensive transcriptomic analysis of covid-19 blood, lung, and airway
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/af04a84c540243f9813b38aac1d0e6e6
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Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway

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