Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells

Caveolae are mechanosensors and mutations of their coat proteins are implicated in muscle disorders, but molecular mechanisms are unclear. Here, the authors show that caveolae can regulate IL6/STAT3 signaling in muscle cells under stress, and that dystrophy related Cav3 mutant myotubes have reduced...

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Autores principales:	Melissa Dewulf, Darius Vasco Köster, Bidisha Sinha, Christine Viaris de Lesegno, Valérie Chambon, Anne Bigot, Mona Bensalah, Elisa Negroni, Nicolas Tardif, Joanna Podkalicka, Ludger Johannes, Pierre Nassoy, Gillian Butler-Browne, Christophe Lamaze, Cedric M. Blouin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af0a410ef64d4e98b3b78ef974859a6d
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spelling	oai:doaj.org-article:af0a410ef64d4e98b3b78ef974859a6d2021-12-02T15:35:32ZDystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells10.1038/s41467-019-09405-52041-1723https://doaj.org/article/af0a410ef64d4e98b3b78ef974859a6d2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09405-5https://doaj.org/toc/2041-1723Caveolae are mechanosensors and mutations of their coat proteins are implicated in muscle disorders, but molecular mechanisms are unclear. Here, the authors show that caveolae can regulate IL6/STAT3 signaling in muscle cells under stress, and that dystrophy related Cav3 mutant myotubes have reduced caveolae and upregulated IL6 signaling.Melissa DewulfDarius Vasco KösterBidisha SinhaChristine Viaris de LesegnoValérie ChambonAnne BigotMona BensalahElisa NegroniNicolas TardifJoanna PodkalickaLudger JohannesPierre NassoyGillian Butler-BrowneChristophe LamazeCedric M. BlouinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Melissa Dewulf Darius Vasco Köster Bidisha Sinha Christine Viaris de Lesegno Valérie Chambon Anne Bigot Mona Bensalah Elisa Negroni Nicolas Tardif Joanna Podkalicka Ludger Johannes Pierre Nassoy Gillian Butler-Browne Christophe Lamaze Cedric M. Blouin Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells
description	Caveolae are mechanosensors and mutations of their coat proteins are implicated in muscle disorders, but molecular mechanisms are unclear. Here, the authors show that caveolae can regulate IL6/STAT3 signaling in muscle cells under stress, and that dystrophy related Cav3 mutant myotubes have reduced caveolae and upregulated IL6 signaling.
format	article
author	Melissa Dewulf Darius Vasco Köster Bidisha Sinha Christine Viaris de Lesegno Valérie Chambon Anne Bigot Mona Bensalah Elisa Negroni Nicolas Tardif Joanna Podkalicka Ludger Johannes Pierre Nassoy Gillian Butler-Browne Christophe Lamaze Cedric M. Blouin
author_facet	Melissa Dewulf Darius Vasco Köster Bidisha Sinha Christine Viaris de Lesegno Valérie Chambon Anne Bigot Mona Bensalah Elisa Negroni Nicolas Tardif Joanna Podkalicka Ludger Johannes Pierre Nassoy Gillian Butler-Browne Christophe Lamaze Cedric M. Blouin
author_sort	Melissa Dewulf
title	Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells
title_short	Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells
title_full	Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells
title_fullStr	Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells
title_full_unstemmed	Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells
title_sort	dystrophy-associated caveolin-3 mutations reveal that caveolae couple il6/stat3 signaling with mechanosensing in human muscle cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/af0a410ef64d4e98b3b78ef974859a6d
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Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells

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