Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities

The mechanism of U6 small nuclear ribonucleoprotein (snRNP) biogenesis is not well understood. Here the authors characterize the enzymatic activities and structures of yeast and human U6 RNA processing enzyme Usb1, reconstitute post-transcriptional assembly of yeast U6 snRNP in vitro, and propose a...

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Autores principales:	Allison L. Didychuk, Eric J. Montemayor, Tucker J. Carrocci, Andrew T. DeLaitsch, Stefani E. Lucarelli, William M. Westler, David A. Brow, Aaron A. Hoskins, Samuel E. Butcher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af0bae0e35e0403b9769387c02748283
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spelling	oai:doaj.org-article:af0bae0e35e0403b9769387c027482832021-12-02T17:06:21ZUsb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities10.1038/s41467-017-00484-w2041-1723https://doaj.org/article/af0bae0e35e0403b9769387c027482832017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00484-whttps://doaj.org/toc/2041-1723The mechanism of U6 small nuclear ribonucleoprotein (snRNP) biogenesis is not well understood. Here the authors characterize the enzymatic activities and structures of yeast and human U6 RNA processing enzyme Usb1, reconstitute post-transcriptional assembly of yeast U6 snRNP in vitro, and propose a model for U6 snRNP assembly.Allison L. DidychukEric J. MontemayorTucker J. CarrocciAndrew T. DeLaitschStefani E. LucarelliWilliam M. WestlerDavid A. BrowAaron A. HoskinsSamuel E. ButcherNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Allison L. Didychuk Eric J. Montemayor Tucker J. Carrocci Andrew T. DeLaitsch Stefani E. Lucarelli William M. Westler David A. Brow Aaron A. Hoskins Samuel E. Butcher Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities
description	The mechanism of U6 small nuclear ribonucleoprotein (snRNP) biogenesis is not well understood. Here the authors characterize the enzymatic activities and structures of yeast and human U6 RNA processing enzyme Usb1, reconstitute post-transcriptional assembly of yeast U6 snRNP in vitro, and propose a model for U6 snRNP assembly.
format	article
author	Allison L. Didychuk Eric J. Montemayor Tucker J. Carrocci Andrew T. DeLaitsch Stefani E. Lucarelli William M. Westler David A. Brow Aaron A. Hoskins Samuel E. Butcher
author_facet	Allison L. Didychuk Eric J. Montemayor Tucker J. Carrocci Andrew T. DeLaitsch Stefani E. Lucarelli William M. Westler David A. Brow Aaron A. Hoskins Samuel E. Butcher
author_sort	Allison L. Didychuk
title	Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities
title_short	Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities
title_full	Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities
title_fullStr	Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities
title_full_unstemmed	Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities
title_sort	usb1 controls u6 snrnp assembly through evolutionarily divergent cyclic phosphodiesterase activities
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/af0bae0e35e0403b9769387c02748283
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Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities

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