A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information

Network-based data integration for drug–target prediction is a promising avenue for drug repositioning, but performance is wanting. Here, the authors introduce DTINet, whose performance is enhanced in the face of noisy, incomplete and high-dimensional biological data by learning low-dimensional vect...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yunan Luo, Xinbin Zhao, Jingtian Zhou, Jinglin Yang, Yanqing Zhang, Wenhua Kuang, Jian Peng, Ligong Chen, Jianyang Zeng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af0ec87cc2674025b7de4031ef5792be
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:af0ec87cc2674025b7de4031ef5792be
record_format	dspace
spelling	oai:doaj.org-article:af0ec87cc2674025b7de4031ef5792be2021-12-02T14:40:26ZA network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information10.1038/s41467-017-00680-82041-1723https://doaj.org/article/af0ec87cc2674025b7de4031ef5792be2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00680-8https://doaj.org/toc/2041-1723Network-based data integration for drug–target prediction is a promising avenue for drug repositioning, but performance is wanting. Here, the authors introduce DTINet, whose performance is enhanced in the face of noisy, incomplete and high-dimensional biological data by learning low-dimensional vector representations.Yunan LuoXinbin ZhaoJingtian ZhouJinglin YangYanqing ZhangWenhua KuangJian PengLigong ChenJianyang ZengNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yunan Luo Xinbin Zhao Jingtian Zhou Jinglin Yang Yanqing Zhang Wenhua Kuang Jian Peng Ligong Chen Jianyang Zeng A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information
description	Network-based data integration for drug–target prediction is a promising avenue for drug repositioning, but performance is wanting. Here, the authors introduce DTINet, whose performance is enhanced in the face of noisy, incomplete and high-dimensional biological data by learning low-dimensional vector representations.
format	article
author	Yunan Luo Xinbin Zhao Jingtian Zhou Jinglin Yang Yanqing Zhang Wenhua Kuang Jian Peng Ligong Chen Jianyang Zeng
author_facet	Yunan Luo Xinbin Zhao Jingtian Zhou Jinglin Yang Yanqing Zhang Wenhua Kuang Jian Peng Ligong Chen Jianyang Zeng
author_sort	Yunan Luo
title	A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information
title_short	A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information
title_full	A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information
title_fullStr	A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information
title_full_unstemmed	A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information
title_sort	network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/af0ec87cc2674025b7de4031ef5792be
work_keys_str_mv	AT yunanluo anetworkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation AT xinbinzhao anetworkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation AT jingtianzhou anetworkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation AT jinglinyang anetworkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation AT yanqingzhang anetworkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation AT wenhuakuang anetworkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation AT jianpeng anetworkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation AT ligongchen anetworkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation AT jianyangzeng anetworkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation AT yunanluo networkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation AT xinbinzhao networkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation AT jingtianzhou networkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation AT jinglinyang networkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation AT yanqingzhang networkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation AT wenhuakuang networkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation AT jianpeng networkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation AT ligongchen networkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation AT jianyangzeng networkintegrationapproachfordrugtargetinteractionpredictionandcomputationaldrugrepositioningfromheterogeneousinformation
_version_	1718390317968785408

A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information

Ejemplares similares