The role of platelets in mediating a response to human influenza infection

Influenza viremia is rare in human blood and not well studied. Here, the authors show that influenza can be found in human platelets and that platelet engulfment of influenza A results in TLR7-dependent C3 release, which in turn promotes neutrophil-DNA release and formation of platelet-DNA aggregate...

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Autores principales:	Milka Koupenova, Heather A. Corkrey, Olga Vitseva, Giorgia Manni, Catherine J. Pang, Lauren Clancy, Chen Yao, Jeffrey Rade, Daniel Levy, Jennifer P. Wang, Robert W. Finberg, Evelyn A. Kurt-Jones, Jane E. Freedman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af0f74c3b44c481eb070539a669dd2de
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spelling	oai:doaj.org-article:af0f74c3b44c481eb070539a669dd2de2021-12-02T17:01:32ZThe role of platelets in mediating a response to human influenza infection10.1038/s41467-019-09607-x2041-1723https://doaj.org/article/af0f74c3b44c481eb070539a669dd2de2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09607-xhttps://doaj.org/toc/2041-1723Influenza viremia is rare in human blood and not well studied. Here, the authors show that influenza can be found in human platelets and that platelet engulfment of influenza A results in TLR7-dependent C3 release, which in turn promotes neutrophil-DNA release and formation of platelet-DNA aggregates.Milka KoupenovaHeather A. CorkreyOlga VitsevaGiorgia ManniCatherine J. PangLauren ClancyChen YaoJeffrey RadeDaniel LevyJennifer P. WangRobert W. FinbergEvelyn A. Kurt-JonesJane E. FreedmanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Milka Koupenova Heather A. Corkrey Olga Vitseva Giorgia Manni Catherine J. Pang Lauren Clancy Chen Yao Jeffrey Rade Daniel Levy Jennifer P. Wang Robert W. Finberg Evelyn A. Kurt-Jones Jane E. Freedman The role of platelets in mediating a response to human influenza infection
description	Influenza viremia is rare in human blood and not well studied. Here, the authors show that influenza can be found in human platelets and that platelet engulfment of influenza A results in TLR7-dependent C3 release, which in turn promotes neutrophil-DNA release and formation of platelet-DNA aggregates.
format	article
author	Milka Koupenova Heather A. Corkrey Olga Vitseva Giorgia Manni Catherine J. Pang Lauren Clancy Chen Yao Jeffrey Rade Daniel Levy Jennifer P. Wang Robert W. Finberg Evelyn A. Kurt-Jones Jane E. Freedman
author_facet	Milka Koupenova Heather A. Corkrey Olga Vitseva Giorgia Manni Catherine J. Pang Lauren Clancy Chen Yao Jeffrey Rade Daniel Levy Jennifer P. Wang Robert W. Finberg Evelyn A. Kurt-Jones Jane E. Freedman
author_sort	Milka Koupenova
title	The role of platelets in mediating a response to human influenza infection
title_short	The role of platelets in mediating a response to human influenza infection
title_full	The role of platelets in mediating a response to human influenza infection
title_fullStr	The role of platelets in mediating a response to human influenza infection
title_full_unstemmed	The role of platelets in mediating a response to human influenza infection
title_sort	role of platelets in mediating a response to human influenza infection
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/af0f74c3b44c481eb070539a669dd2de
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The role of platelets in mediating a response to human influenza infection

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