Consistency of the disposition index in the face of diet induced insulin resistance: potential role of FFA.

<h4>Objective</h4>Insulin resistance induces hyperinsulinemic compensation, which in turn maintains almost a constant disposition index. However, the signal that gives rise to the hyperinsulinemic compensation for insulin resistance remains unknown.<h4>Methods</h4>In a dog mo...

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Autores principales:	Darko Stefanovski, Joyce M Richey, Orison Woolcott, Maya Lottati, Dan Zheng, Lisa N Harrison, Viorica Ionut, Stella P Kim, Isabel Hsu, Richard N Bergman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/af10d06985ef4017b754aa68995fdbb7
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spelling	oai:doaj.org-article:af10d06985ef4017b754aa68995fdbb72021-11-18T06:56:30ZConsistency of the disposition index in the face of diet induced insulin resistance: potential role of FFA.1932-620310.1371/journal.pone.0018134https://doaj.org/article/af10d06985ef4017b754aa68995fdbb72011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21479217/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Insulin resistance induces hyperinsulinemic compensation, which in turn maintains almost a constant disposition index. However, the signal that gives rise to the hyperinsulinemic compensation for insulin resistance remains unknown.<h4>Methods</h4>In a dog model of obesity we examined the possibility that potential early-week changes in plasma FFA, glucose, or both could be part of a cascade of signals that lead to compensatory hyperinsulinemia induced by insulin resistance.<h4>Results</h4>Hypercaloric high fat feeding in dogs resulted in modest weight gain, and an increase in adipose tissue with no change in the non-adipose tissue size. To compensate for the drop in insulin sensitivity, there was a significant rise in plasma insulin, which can be attributed in part to a decrease in the metabolic clearance rate of insulin and increased insulin secretion. In this study we observed complete compensation for high fat diet induced insulin resistance as measured by the disposition index. The compensatory hyperinsulinemia was coupled with significant changes in plasma FFAs and no change in plasma glucose.<h4>Conclusions</h4>We postulate that early in the development of diet induced insulin resistance, a change in plasma FFAs may directly, through signaling at the level of β-cell, or indirectly, by decreasing hepatic insulin clearance, result in the observed hyperinsulinemic compensation.Darko StefanovskiJoyce M RicheyOrison WoolcottMaya LottatiDan ZhengLisa N HarrisonViorica IonutStella P KimIsabel HsuRichard N BergmanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 3, p e18134 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Darko Stefanovski Joyce M Richey Orison Woolcott Maya Lottati Dan Zheng Lisa N Harrison Viorica Ionut Stella P Kim Isabel Hsu Richard N Bergman Consistency of the disposition index in the face of diet induced insulin resistance: potential role of FFA.
description	<h4>Objective</h4>Insulin resistance induces hyperinsulinemic compensation, which in turn maintains almost a constant disposition index. However, the signal that gives rise to the hyperinsulinemic compensation for insulin resistance remains unknown.<h4>Methods</h4>In a dog model of obesity we examined the possibility that potential early-week changes in plasma FFA, glucose, or both could be part of a cascade of signals that lead to compensatory hyperinsulinemia induced by insulin resistance.<h4>Results</h4>Hypercaloric high fat feeding in dogs resulted in modest weight gain, and an increase in adipose tissue with no change in the non-adipose tissue size. To compensate for the drop in insulin sensitivity, there was a significant rise in plasma insulin, which can be attributed in part to a decrease in the metabolic clearance rate of insulin and increased insulin secretion. In this study we observed complete compensation for high fat diet induced insulin resistance as measured by the disposition index. The compensatory hyperinsulinemia was coupled with significant changes in plasma FFAs and no change in plasma glucose.<h4>Conclusions</h4>We postulate that early in the development of diet induced insulin resistance, a change in plasma FFAs may directly, through signaling at the level of β-cell, or indirectly, by decreasing hepatic insulin clearance, result in the observed hyperinsulinemic compensation.
format	article
author	Darko Stefanovski Joyce M Richey Orison Woolcott Maya Lottati Dan Zheng Lisa N Harrison Viorica Ionut Stella P Kim Isabel Hsu Richard N Bergman
author_facet	Darko Stefanovski Joyce M Richey Orison Woolcott Maya Lottati Dan Zheng Lisa N Harrison Viorica Ionut Stella P Kim Isabel Hsu Richard N Bergman
author_sort	Darko Stefanovski
title	Consistency of the disposition index in the face of diet induced insulin resistance: potential role of FFA.
title_short	Consistency of the disposition index in the face of diet induced insulin resistance: potential role of FFA.
title_full	Consistency of the disposition index in the face of diet induced insulin resistance: potential role of FFA.
title_fullStr	Consistency of the disposition index in the face of diet induced insulin resistance: potential role of FFA.
title_full_unstemmed	Consistency of the disposition index in the face of diet induced insulin resistance: potential role of FFA.
title_sort	consistency of the disposition index in the face of diet induced insulin resistance: potential role of ffa.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/af10d06985ef4017b754aa68995fdbb7
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Consistency of the disposition index in the face of diet induced insulin resistance: potential role of FFA.

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