Complimentary action of structured and unstructured domains of epsin supports clathrin-mediated endocytosis at high tension

Using imaging and molecular dynamics simulations, Joseph et al characterize the tension-responsive recruitment of the membrane bending protein epsin and its stabilization of clathrin-coated structures (CCSs) to form clathrin-coated pits. They find epsin’s ENTH- and unstructured IDP domains play comp...

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Autores principales:	Jophin G. Joseph, Carlos Osorio, Vivian Yee, Ashutosh Agrawal, Allen P. Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/af160bb607ba4d5e9eee489c34d49af9
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spelling	oai:doaj.org-article:af160bb607ba4d5e9eee489c34d49af92021-12-02T12:33:13ZComplimentary action of structured and unstructured domains of epsin supports clathrin-mediated endocytosis at high tension10.1038/s42003-020-01471-62399-3642https://doaj.org/article/af160bb607ba4d5e9eee489c34d49af92020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01471-6https://doaj.org/toc/2399-3642Using imaging and molecular dynamics simulations, Joseph et al characterize the tension-responsive recruitment of the membrane bending protein epsin and its stabilization of clathrin-coated structures (CCSs) to form clathrin-coated pits. They find epsin’s ENTH- and unstructured IDP domains play complementary roles in CCS maturation under high tension.Jophin G. JosephCarlos OsorioVivian YeeAshutosh AgrawalAllen P. LiuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jophin G. Joseph Carlos Osorio Vivian Yee Ashutosh Agrawal Allen P. Liu Complimentary action of structured and unstructured domains of epsin supports clathrin-mediated endocytosis at high tension
description	Using imaging and molecular dynamics simulations, Joseph et al characterize the tension-responsive recruitment of the membrane bending protein epsin and its stabilization of clathrin-coated structures (CCSs) to form clathrin-coated pits. They find epsin’s ENTH- and unstructured IDP domains play complementary roles in CCS maturation under high tension.
format	article
author	Jophin G. Joseph Carlos Osorio Vivian Yee Ashutosh Agrawal Allen P. Liu
author_facet	Jophin G. Joseph Carlos Osorio Vivian Yee Ashutosh Agrawal Allen P. Liu
author_sort	Jophin G. Joseph
title	Complimentary action of structured and unstructured domains of epsin supports clathrin-mediated endocytosis at high tension
title_short	Complimentary action of structured and unstructured domains of epsin supports clathrin-mediated endocytosis at high tension
title_full	Complimentary action of structured and unstructured domains of epsin supports clathrin-mediated endocytosis at high tension
title_fullStr	Complimentary action of structured and unstructured domains of epsin supports clathrin-mediated endocytosis at high tension
title_full_unstemmed	Complimentary action of structured and unstructured domains of epsin supports clathrin-mediated endocytosis at high tension
title_sort	complimentary action of structured and unstructured domains of epsin supports clathrin-mediated endocytosis at high tension
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/af160bb607ba4d5e9eee489c34d49af9
work_keys_str_mv	AT jophingjoseph complimentaryactionofstructuredandunstructureddomainsofepsinsupportsclathrinmediatedendocytosisathightension AT carlososorio complimentaryactionofstructuredandunstructureddomainsofepsinsupportsclathrinmediatedendocytosisathightension AT vivianyee complimentaryactionofstructuredandunstructureddomainsofepsinsupportsclathrinmediatedendocytosisathightension AT ashutoshagrawal complimentaryactionofstructuredandunstructureddomainsofepsinsupportsclathrinmediatedendocytosisathightension AT allenpliu complimentaryactionofstructuredandunstructureddomainsofepsinsupportsclathrinmediatedendocytosisathightension
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Complimentary action of structured and unstructured domains of epsin supports clathrin-mediated endocytosis at high tension

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