Copeptin as a novel marker predicting prognosis of liver cirrhosis and its major complications

Ahmed Khaled Tawfik,1 Amal Helmy,2 Mohamed Yousef,1 Sabry Abou-Saif,1 Abdelrahman Kobtan,1 Eman Asaad,1 Sherief Abd-Elsalam1 1Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, Tanta, Egypt; 2Department of Clinical Pathology, Faculty of Medicine, Tanta Un...

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Autores principales:	Tawfik AK, Helmy A, Yousef M, Abou-Saif S, Kobtan A, Asaad E, Abd-Elsalam S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Cirrhosis Hepatorenal syndrome liver failure Varices Prognosis Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/af19104219e346f098f39cd91b3601dc
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spelling	oai:doaj.org-article:af19104219e346f098f39cd91b3601dc2021-12-02T03:34:25ZCopeptin as a novel marker predicting prognosis of liver cirrhosis and its major complications1179-1535https://doaj.org/article/af19104219e346f098f39cd91b3601dc2018-09-01T00:00:00Zhttps://www.dovepress.com/copeptin-as-a-novel-marker-predicting-prognosis-of-liver-cirrhosis-and-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535Ahmed Khaled Tawfik,1 Amal Helmy,2 Mohamed Yousef,1 Sabry Abou-Saif,1 Abdelrahman Kobtan,1 Eman Asaad,1 Sherief Abd-Elsalam1 1Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, Tanta, Egypt; 2Department of Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt Objectives: The aim of the work was to assess the level of copeptin as a surrogate marker predicting the severity of liver diseases and its major complications.Patients and methods: This was a cross-sectional study that included 40 patients and 10 controls and was performed in Tanta University Hospital between June 2016 and November 2016. The studied cases were divided into five groups: group I (10 patients): compensated cirrhosis; group II (10 patients): cirrhosis with gastrointestinal hemorrhage due to portal hypertension; group III (10 patients): cirrhosis with hepatorenal syndrome; group IV (10 patients): cirrhosis with liver cell failure; and group V (10 controls): normal healthy individuals.Results: Regarding serum copeptin in the studied groups, copeptin showed a significant decrease in group I vs group II&sbquo; group I vs group III, and group I vs group IV; and there was a significant increase in group II vs group III&sbquo; group II vs group IV&sbquo; group II vs control&sbquo; group III vs control, and group IV vs control. No significance was detected between group I vs control and group III vs group IV.Conclusions: Copeptin is a novel marker for the determination of prognosis of liver cirrhosis. There is significant association between serum level of copeptin and complications of liver cirrhosis. Keywords: cirrhosis, hepatorenal syndrome, liver failure, varices, prognosisTawfik AKHelmy AYousef MAbou-Saif SKobtan AAsaad EAbd-Elsalam SDove Medical PressarticleCirrhosisHepatorenal syndromeliver failureVaricesPrognosisDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol Volume 10, Pp 87-93 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cirrhosis Hepatorenal syndrome liver failure Varices Prognosis Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Cirrhosis Hepatorenal syndrome liver failure Varices Prognosis Diseases of the digestive system. Gastroenterology RC799-869 Tawfik AK Helmy A Yousef M Abou-Saif S Kobtan A Asaad E Abd-Elsalam S Copeptin as a novel marker predicting prognosis of liver cirrhosis and its major complications
description	Ahmed Khaled Tawfik,1 Amal Helmy,2 Mohamed Yousef,1 Sabry Abou-Saif,1 Abdelrahman Kobtan,1 Eman Asaad,1 Sherief Abd-Elsalam1 1Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, Tanta, Egypt; 2Department of Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt Objectives: The aim of the work was to assess the level of copeptin as a surrogate marker predicting the severity of liver diseases and its major complications.Patients and methods: This was a cross-sectional study that included 40 patients and 10 controls and was performed in Tanta University Hospital between June 2016 and November 2016. The studied cases were divided into five groups: group I (10 patients): compensated cirrhosis; group II (10 patients): cirrhosis with gastrointestinal hemorrhage due to portal hypertension; group III (10 patients): cirrhosis with hepatorenal syndrome; group IV (10 patients): cirrhosis with liver cell failure; and group V (10 controls): normal healthy individuals.Results: Regarding serum copeptin in the studied groups, copeptin showed a significant decrease in group I vs group II&sbquo; group I vs group III, and group I vs group IV; and there was a significant increase in group II vs group III&sbquo; group II vs group IV&sbquo; group II vs control&sbquo; group III vs control, and group IV vs control. No significance was detected between group I vs control and group III vs group IV.Conclusions: Copeptin is a novel marker for the determination of prognosis of liver cirrhosis. There is significant association between serum level of copeptin and complications of liver cirrhosis. Keywords: cirrhosis, hepatorenal syndrome, liver failure, varices, prognosis
format	article
author	Tawfik AK Helmy A Yousef M Abou-Saif S Kobtan A Asaad E Abd-Elsalam S
author_facet	Tawfik AK Helmy A Yousef M Abou-Saif S Kobtan A Asaad E Abd-Elsalam S
author_sort	Tawfik AK
title	Copeptin as a novel marker predicting prognosis of liver cirrhosis and its major complications
title_short	Copeptin as a novel marker predicting prognosis of liver cirrhosis and its major complications
title_full	Copeptin as a novel marker predicting prognosis of liver cirrhosis and its major complications
title_fullStr	Copeptin as a novel marker predicting prognosis of liver cirrhosis and its major complications
title_full_unstemmed	Copeptin as a novel marker predicting prognosis of liver cirrhosis and its major complications
title_sort	copeptin as a novel marker predicting prognosis of liver cirrhosis and its major complications
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/af19104219e346f098f39cd91b3601dc
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Copeptin as a novel marker predicting prognosis of liver cirrhosis and its major complications

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