Structural Remodeling of the Extracellular Matrix in Arteriogenesis: A Review

Lower extremity arterial occlusive disease (AOD) results in significant morbidity and mortality for the population, with up to 10% of patients ultimately requiring amputation. An alternative method for non-surgical revascularization which is yet to be fully understood is the optimization of the body...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rohan Kulkarni, Elizabeth Andraska, Ryan McEnaney
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	arteriogenesis extracellular matrix elastic fiber outward remodeling collateral arteries arterial occlusive disease Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/af19d21481fd4eacb260525523636a13
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:af19d21481fd4eacb260525523636a13
record_format	dspace
spelling	oai:doaj.org-article:af19d21481fd4eacb260525523636a132021-11-05T09:21:27ZStructural Remodeling of the Extracellular Matrix in Arteriogenesis: A Review2297-055X10.3389/fcvm.2021.761007https://doaj.org/article/af19d21481fd4eacb260525523636a132021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.761007/fullhttps://doaj.org/toc/2297-055XLower extremity arterial occlusive disease (AOD) results in significant morbidity and mortality for the population, with up to 10% of patients ultimately requiring amputation. An alternative method for non-surgical revascularization which is yet to be fully understood is the optimization of the body's own natural collateral arterial network in a process known as arteriogenesis. Under conditions of conductance vessel stenosis or occlusion resulting in increased flow, shear forces, and pressure gradients within collaterals, positive remodeling occurs to increase the diameter and capacity of these vessels. The creation of a distal arteriovenous fistula (AVF) will drive increased arteriogenesis as compared to collateral formation with the occlusion of a conductance vessel alone by further increasing flow through these arterioles, demonstrating the capacity for arteriogenesis to form larger, more efficient collaterals beyond what is spontaneously achieved after arterial occlusion. Arteries rely on an extracellular matrix (ECM) composed of elastic fibers and collagens that provide stability under hemodynamic stress, and ECM remodeling is necessary to allow for increased diameter and flow conductance in mature arterial structures. When positive remodeling occurs, digestion of lamella and the internal elastic lamina (IEL) by matrix metalloproteinases (MMPs) and other elastases results in the rearrangement and thinning of elastic structures and may be replaced with disordered elastin synthesis without recovery of elastic function. This results in transmission of wall strain to collagen and potential for aneurysmal degeneration along collateral networks, as is seen in the pancreaticoduodenal artery (PDA) after celiac occlusion and inferior mesenteric artery (IMA) with concurrent celiac and superior mesenteric artery (SMA) occlusions. Further understanding into the development of collaterals is required to both better understand aneurysmal degeneration and optimize collateral formation in AOD.Rohan KulkarniElizabeth AndraskaRyan McEnaneyRyan McEnaneyFrontiers Media S.A.articlearteriogenesisextracellular matrixelastic fiberoutward remodelingcollateral arteriesarterial occlusive diseaseDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arteriogenesis extracellular matrix elastic fiber outward remodeling collateral arteries arterial occlusive disease Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	arteriogenesis extracellular matrix elastic fiber outward remodeling collateral arteries arterial occlusive disease Diseases of the circulatory (Cardiovascular) system RC666-701 Rohan Kulkarni Elizabeth Andraska Ryan McEnaney Ryan McEnaney Structural Remodeling of the Extracellular Matrix in Arteriogenesis: A Review
description	Lower extremity arterial occlusive disease (AOD) results in significant morbidity and mortality for the population, with up to 10% of patients ultimately requiring amputation. An alternative method for non-surgical revascularization which is yet to be fully understood is the optimization of the body's own natural collateral arterial network in a process known as arteriogenesis. Under conditions of conductance vessel stenosis or occlusion resulting in increased flow, shear forces, and pressure gradients within collaterals, positive remodeling occurs to increase the diameter and capacity of these vessels. The creation of a distal arteriovenous fistula (AVF) will drive increased arteriogenesis as compared to collateral formation with the occlusion of a conductance vessel alone by further increasing flow through these arterioles, demonstrating the capacity for arteriogenesis to form larger, more efficient collaterals beyond what is spontaneously achieved after arterial occlusion. Arteries rely on an extracellular matrix (ECM) composed of elastic fibers and collagens that provide stability under hemodynamic stress, and ECM remodeling is necessary to allow for increased diameter and flow conductance in mature arterial structures. When positive remodeling occurs, digestion of lamella and the internal elastic lamina (IEL) by matrix metalloproteinases (MMPs) and other elastases results in the rearrangement and thinning of elastic structures and may be replaced with disordered elastin synthesis without recovery of elastic function. This results in transmission of wall strain to collagen and potential for aneurysmal degeneration along collateral networks, as is seen in the pancreaticoduodenal artery (PDA) after celiac occlusion and inferior mesenteric artery (IMA) with concurrent celiac and superior mesenteric artery (SMA) occlusions. Further understanding into the development of collaterals is required to both better understand aneurysmal degeneration and optimize collateral formation in AOD.
format	article
author	Rohan Kulkarni Elizabeth Andraska Ryan McEnaney Ryan McEnaney
author_facet	Rohan Kulkarni Elizabeth Andraska Ryan McEnaney Ryan McEnaney
author_sort	Rohan Kulkarni
title	Structural Remodeling of the Extracellular Matrix in Arteriogenesis: A Review
title_short	Structural Remodeling of the Extracellular Matrix in Arteriogenesis: A Review
title_full	Structural Remodeling of the Extracellular Matrix in Arteriogenesis: A Review
title_fullStr	Structural Remodeling of the Extracellular Matrix in Arteriogenesis: A Review
title_full_unstemmed	Structural Remodeling of the Extracellular Matrix in Arteriogenesis: A Review
title_sort	structural remodeling of the extracellular matrix in arteriogenesis: a review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/af19d21481fd4eacb260525523636a13
work_keys_str_mv	AT rohankulkarni structuralremodelingoftheextracellularmatrixinarteriogenesisareview AT elizabethandraska structuralremodelingoftheextracellularmatrixinarteriogenesisareview AT ryanmcenaney structuralremodelingoftheextracellularmatrixinarteriogenesisareview AT ryanmcenaney structuralremodelingoftheextracellularmatrixinarteriogenesisareview
_version_	1718444430129627136

Structural Remodeling of the Extracellular Matrix in Arteriogenesis: A Review

Ejemplares similares