Corneal biomechanics in asymmetrical normal-tension glaucoma

Hazem Helmy,1 Mahmoud Leila,2 Ahmed Atef Zaki3 1Department of Glaucoma and Optic Nerve Diseases, 2Retina Department, 3Corneal Diseases Department, Research Institute of Ophthalmology, Cairo, Egypt Purpose: We aimed to assess corneal biomechanics using the ocular response analyzer in patients with...

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Autores principales:	Helmy H, Leila M, Zaki AA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Corneal Biomechanics – Corneal Hysteresis – Corneal Resistance Factor – Asymmetrical Normal Tension Glaucoma Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/af21e61d292d4d1cb04dc537d0d01b71
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spelling	oai:doaj.org-article:af21e61d292d4d1cb04dc537d0d01b712021-12-02T02:52:35ZCorneal biomechanics in asymmetrical normal-tension glaucoma1177-5483https://doaj.org/article/af21e61d292d4d1cb04dc537d0d01b712016-03-01T00:00:00Zhttps://www.dovepress.com/corneal-biomechanics-in-asymmetrical-normal-tension-glaucoma-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Hazem Helmy,1 Mahmoud Leila,2 Ahmed Atef Zaki3 1Department of Glaucoma and Optic Nerve Diseases, 2Retina Department, 3Corneal Diseases Department, Research Institute of Ophthalmology, Cairo, Egypt Purpose: We aimed to assess corneal biomechanics using the ocular response analyzer in patients with normal-tension glaucoma (NTG), and to evaluate the relationship between corneal biomechanics and visual field loss. Methods: This was a prospective observational case series including patients with bilateral asymmetric NTG. For all patients, corneal hysteresis (CH), corneal resistance factor (CRF), CH - CRF difference, and central corneal thickness values were matched against the mean deviation (MD) of the visual field and the cup/disc ratio. For paired-eye comparison in each patient, both eyes were categorized into a better-eyes group and a worse-eyes group according to lower and higher corneal-compensated intraocular pressure readings, respectively. Statistical analysis was carried out with the independent-samples Student’s t-test, and the level of statistical significance was set at 0.05. Correlation was assessed using Pearson’s correlation coefficient. Results: The study included 240 eyes of 120 patients. CH was inversely proportional to the MD in the visual field (P=0.01). CRF in both eyes was inversely proportional to the MD of the visual field (P=0.01). CH - CRF difference was directly proportional to the MD of the visual field (P=0.01). For paired-eye comparison, lower corneal-compensated intraocular pressure was associated with higher CH, higher CRF, smaller cup/disc ratio, and less deterioration of MD of visual field. Conclusion: CH, CRF, and CH - CRF are more powerful predictors of NTG progression than central corneal thickness. Keywords: corneal-compensated intraocular pressure, corneal hysteresis, corneal resistance factorHelmy HLeila MZaki AADove Medical PressarticleCorneal Biomechanics – Corneal Hysteresis – Corneal Resistance Factor – Asymmetrical Normal Tension GlaucomaOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 503-510 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Corneal Biomechanics – Corneal Hysteresis – Corneal Resistance Factor – Asymmetrical Normal Tension Glaucoma Ophthalmology RE1-994
spellingShingle	Corneal Biomechanics – Corneal Hysteresis – Corneal Resistance Factor – Asymmetrical Normal Tension Glaucoma Ophthalmology RE1-994 Helmy H Leila M Zaki AA Corneal biomechanics in asymmetrical normal-tension glaucoma
description	Hazem Helmy,1 Mahmoud Leila,2 Ahmed Atef Zaki3 1Department of Glaucoma and Optic Nerve Diseases, 2Retina Department, 3Corneal Diseases Department, Research Institute of Ophthalmology, Cairo, Egypt Purpose: We aimed to assess corneal biomechanics using the ocular response analyzer in patients with normal-tension glaucoma (NTG), and to evaluate the relationship between corneal biomechanics and visual field loss. Methods: This was a prospective observational case series including patients with bilateral asymmetric NTG. For all patients, corneal hysteresis (CH), corneal resistance factor (CRF), CH - CRF difference, and central corneal thickness values were matched against the mean deviation (MD) of the visual field and the cup/disc ratio. For paired-eye comparison in each patient, both eyes were categorized into a better-eyes group and a worse-eyes group according to lower and higher corneal-compensated intraocular pressure readings, respectively. Statistical analysis was carried out with the independent-samples Student’s t-test, and the level of statistical significance was set at 0.05. Correlation was assessed using Pearson’s correlation coefficient. Results: The study included 240 eyes of 120 patients. CH was inversely proportional to the MD in the visual field (P=0.01). CRF in both eyes was inversely proportional to the MD of the visual field (P=0.01). CH - CRF difference was directly proportional to the MD of the visual field (P=0.01). For paired-eye comparison, lower corneal-compensated intraocular pressure was associated with higher CH, higher CRF, smaller cup/disc ratio, and less deterioration of MD of visual field. Conclusion: CH, CRF, and CH - CRF are more powerful predictors of NTG progression than central corneal thickness. Keywords: corneal-compensated intraocular pressure, corneal hysteresis, corneal resistance factor
format	article
author	Helmy H Leila M Zaki AA
author_facet	Helmy H Leila M Zaki AA
author_sort	Helmy H
title	Corneal biomechanics in asymmetrical normal-tension glaucoma
title_short	Corneal biomechanics in asymmetrical normal-tension glaucoma
title_full	Corneal biomechanics in asymmetrical normal-tension glaucoma
title_fullStr	Corneal biomechanics in asymmetrical normal-tension glaucoma
title_full_unstemmed	Corneal biomechanics in asymmetrical normal-tension glaucoma
title_sort	corneal biomechanics in asymmetrical normal-tension glaucoma
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/af21e61d292d4d1cb04dc537d0d01b71
work_keys_str_mv	AT helmyh cornealbiomechanicsinasymmetricalnormaltensionglaucoma AT leilam cornealbiomechanicsinasymmetricalnormaltensionglaucoma AT zakiaa cornealbiomechanicsinasymmetricalnormaltensionglaucoma
_version_	1718402118866436096

Corneal biomechanics in asymmetrical normal-tension glaucoma

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