Collateral Victim or Rescue Worker?—The Role of Histone Methyltransferases in DNA Damage Repair and Their Targeting for Therapeutic Opportunities in Cancer
Disrupted DNA damage signaling greatly threatens cell integrity and plays significant roles in cancer. With recent advances in understanding the human genome and gene regulation in the context of DNA damage, chromatin biology, specifically biology of histone post-translational modifications (PTMs),...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:af2381dee44245b992592dfde72c95fc2021-11-16T06:33:18ZCollateral Victim or Rescue Worker?—The Role of Histone Methyltransferases in DNA Damage Repair and Their Targeting for Therapeutic Opportunities in Cancer2296-634X10.3389/fcell.2021.735107https://doaj.org/article/af2381dee44245b992592dfde72c95fc2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.735107/fullhttps://doaj.org/toc/2296-634XDisrupted DNA damage signaling greatly threatens cell integrity and plays significant roles in cancer. With recent advances in understanding the human genome and gene regulation in the context of DNA damage, chromatin biology, specifically biology of histone post-translational modifications (PTMs), has emerged as a popular field of study with great promise for cancer therapeutics. Here, we discuss how key histone methylation pathways contribute to DNA damage repair and impact tumorigenesis within this context, as well as the potential for their targeting as part of therapeutic strategies in cancer.Lishu HeLishu HeLishu HeGwen LomberkGwen LomberkGwen LomberkGwen LomberkFrontiers Media S.A.articlecancer epigeneticschromatinepigenetic drugshistone methyltransferasesDNA damage repair (DDR)Biology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
cancer epigenetics chromatin epigenetic drugs histone methyltransferases DNA damage repair (DDR) Biology (General) QH301-705.5 |
| spellingShingle |
cancer epigenetics chromatin epigenetic drugs histone methyltransferases DNA damage repair (DDR) Biology (General) QH301-705.5 Lishu He Lishu He Lishu He Gwen Lomberk Gwen Lomberk Gwen Lomberk Gwen Lomberk Collateral Victim or Rescue Worker?—The Role of Histone Methyltransferases in DNA Damage Repair and Their Targeting for Therapeutic Opportunities in Cancer |
| description |
Disrupted DNA damage signaling greatly threatens cell integrity and plays significant roles in cancer. With recent advances in understanding the human genome and gene regulation in the context of DNA damage, chromatin biology, specifically biology of histone post-translational modifications (PTMs), has emerged as a popular field of study with great promise for cancer therapeutics. Here, we discuss how key histone methylation pathways contribute to DNA damage repair and impact tumorigenesis within this context, as well as the potential for their targeting as part of therapeutic strategies in cancer. |
| format |
article |
| author |
Lishu He Lishu He Lishu He Gwen Lomberk Gwen Lomberk Gwen Lomberk Gwen Lomberk |
| author_facet |
Lishu He Lishu He Lishu He Gwen Lomberk Gwen Lomberk Gwen Lomberk Gwen Lomberk |
| author_sort |
Lishu He |
| title |
Collateral Victim or Rescue Worker?—The Role of Histone Methyltransferases in DNA Damage Repair and Their Targeting for Therapeutic Opportunities in Cancer |
| title_short |
Collateral Victim or Rescue Worker?—The Role of Histone Methyltransferases in DNA Damage Repair and Their Targeting for Therapeutic Opportunities in Cancer |
| title_full |
Collateral Victim or Rescue Worker?—The Role of Histone Methyltransferases in DNA Damage Repair and Their Targeting for Therapeutic Opportunities in Cancer |
| title_fullStr |
Collateral Victim or Rescue Worker?—The Role of Histone Methyltransferases in DNA Damage Repair and Their Targeting for Therapeutic Opportunities in Cancer |
| title_full_unstemmed |
Collateral Victim or Rescue Worker?—The Role of Histone Methyltransferases in DNA Damage Repair and Their Targeting for Therapeutic Opportunities in Cancer |
| title_sort |
collateral victim or rescue worker?—the role of histone methyltransferases in dna damage repair and their targeting for therapeutic opportunities in cancer |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/af2381dee44245b992592dfde72c95fc |
| work_keys_str_mv |
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