Accelerated stability test of snakehead fish and kelulut honey ointment with CMC-Na as a binder

The extract of snakehead fish (Channa striata) and kelulut honey (Heterotrigona itama) ointment was proven to have activity in wound healing. However, previous studies showed instability in the ointment as indicated by the occurrence of phase separation. This study used CMC-Na (Carboxymethyl Cellulo...

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Autores principales:	Wintari Taurina, Mohamad Andrie, Nur Firdiena Titian Ratu
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Ahmad Dahlan 2021
Materias:	ointment cmc-na snakehead fish extract kelulut honey accelerated stability Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/af238dece03941c18fe284b334e5e761
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spelling	oai:doaj.org-article:af238dece03941c18fe284b334e5e7612021-11-17T06:58:31ZAccelerated stability test of snakehead fish and kelulut honey ointment with CMC-Na as a binder10.12928/pharmaciana.v11i3.206282088-45592477-0256https://doaj.org/article/af238dece03941c18fe284b334e5e7612021-11-01T00:00:00Zhttp://journal.uad.ac.id/index.php/PHARMACIANA/article/view/20628/pdf_211https://doaj.org/toc/2088-4559https://doaj.org/toc/2477-0256The extract of snakehead fish (Channa striata) and kelulut honey (Heterotrigona itama) ointment was proven to have activity in wound healing. However, previous studies showed instability in the ointment as indicated by the occurrence of phase separation. This study used CMC-Na (Carboxymethyl Cellulose Sodium) with a concentration of 3% (F1), 4.5% (F2), and 6% (F3) as a binder. The stabilizer was added to increase the stability of the ointment preparation by binding to the aqueous phase and preventing it from leaving the ointment base. The test was carried out with the accelerated stability method at a temperature of 40° ± 2° C and a humidity of 75% ± 5% for 28 days. The evaluation includes organoleptic tests, homogeneity, spreadability, adhesion, and protection power. The results showed that CMC-Na increased the stability of the ointment. The data obtained show that the higher the CMC-Na concentration used, the higher the consistency and adhesion were, but the lower the spreadability of the preparation. The results of the average spreadability and adhesion power for formulation 1 were 5.09 cm and 1797.33 seconds, formulation 2 were 4.42 cm and 1798.33 seconds, and formulation 3 were 3.69 cm and 1799 seconds. The results of the One-Way ANOVA showed that all formulations experienced a significant decrease in adhesion and increase in spreadability during 28 days of storage. The best ointment that meets the physical stability criteria is shown by the CMC-Na 3% (F1) formulation, with a soft texture, homogeneous, a good spreadability (5-7 cm), a good adhesion (more than 4 seconds), and a good protective power for 28 days of testing.Wintari TaurinaMohamad AndrieNur Firdiena Titian RatuUniversitas Ahmad Dahlanarticleointmentcmc-nasnakehead fish extractkelulut honeyaccelerated stabilityPharmacy and materia medicaRS1-441ENPharmaciana, Vol 11, Iss 3, Pp 385-393 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ointment cmc-na snakehead fish extract kelulut honey accelerated stability Pharmacy and materia medica RS1-441
spellingShingle	ointment cmc-na snakehead fish extract kelulut honey accelerated stability Pharmacy and materia medica RS1-441 Wintari Taurina Mohamad Andrie Nur Firdiena Titian Ratu Accelerated stability test of snakehead fish and kelulut honey ointment with CMC-Na as a binder
description	The extract of snakehead fish (Channa striata) and kelulut honey (Heterotrigona itama) ointment was proven to have activity in wound healing. However, previous studies showed instability in the ointment as indicated by the occurrence of phase separation. This study used CMC-Na (Carboxymethyl Cellulose Sodium) with a concentration of 3% (F1), 4.5% (F2), and 6% (F3) as a binder. The stabilizer was added to increase the stability of the ointment preparation by binding to the aqueous phase and preventing it from leaving the ointment base. The test was carried out with the accelerated stability method at a temperature of 40° ± 2° C and a humidity of 75% ± 5% for 28 days. The evaluation includes organoleptic tests, homogeneity, spreadability, adhesion, and protection power. The results showed that CMC-Na increased the stability of the ointment. The data obtained show that the higher the CMC-Na concentration used, the higher the consistency and adhesion were, but the lower the spreadability of the preparation. The results of the average spreadability and adhesion power for formulation 1 were 5.09 cm and 1797.33 seconds, formulation 2 were 4.42 cm and 1798.33 seconds, and formulation 3 were 3.69 cm and 1799 seconds. The results of the One-Way ANOVA showed that all formulations experienced a significant decrease in adhesion and increase in spreadability during 28 days of storage. The best ointment that meets the physical stability criteria is shown by the CMC-Na 3% (F1) formulation, with a soft texture, homogeneous, a good spreadability (5-7 cm), a good adhesion (more than 4 seconds), and a good protective power for 28 days of testing.
format	article
author	Wintari Taurina Mohamad Andrie Nur Firdiena Titian Ratu
author_facet	Wintari Taurina Mohamad Andrie Nur Firdiena Titian Ratu
author_sort	Wintari Taurina
title	Accelerated stability test of snakehead fish and kelulut honey ointment with CMC-Na as a binder
title_short	Accelerated stability test of snakehead fish and kelulut honey ointment with CMC-Na as a binder
title_full	Accelerated stability test of snakehead fish and kelulut honey ointment with CMC-Na as a binder
title_fullStr	Accelerated stability test of snakehead fish and kelulut honey ointment with CMC-Na as a binder
title_full_unstemmed	Accelerated stability test of snakehead fish and kelulut honey ointment with CMC-Na as a binder
title_sort	accelerated stability test of snakehead fish and kelulut honey ointment with cmc-na as a binder
publisher	Universitas Ahmad Dahlan
publishDate	2021
url	https://doaj.org/article/af238dece03941c18fe284b334e5e761
work_keys_str_mv	AT wintaritaurina acceleratedstabilitytestofsnakeheadfishandkeluluthoneyointmentwithcmcnaasabinder AT mohamadandrie acceleratedstabilitytestofsnakeheadfishandkeluluthoneyointmentwithcmcnaasabinder AT nurfirdienatitianratu acceleratedstabilitytestofsnakeheadfishandkeluluthoneyointmentwithcmcnaasabinder
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Accelerated stability test of snakehead fish and kelulut honey ointment with CMC-Na as a binder

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