Affective lability as a prospective predictor of subsequent bipolar disorder diagnosis: a systematic review

Abstract Objectives The early pathogenesis and precursors of Bipolar Disorder (BD) are poorly understood. There is some cross-sectional and retrospective evidence of affective lability as a predictor of BD, but this is subject to recall biases. The present review synthesises the prospective evidence...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rosie H. Taylor, Andrea Ulrichsen, Allan H. Young, Rebecca Strawbridge
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Bipolar disorder Systematic review Affective lability Mood instability Prospective Predictor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/af23b21484554302884c749f9230e65c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:af23b21484554302884c749f9230e65c
record_format	dspace
spelling	oai:doaj.org-article:af23b21484554302884c749f9230e65c2021-11-08T10:44:20ZAffective lability as a prospective predictor of subsequent bipolar disorder diagnosis: a systematic review10.1186/s40345-021-00237-12194-7511https://doaj.org/article/af23b21484554302884c749f9230e65c2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40345-021-00237-1https://doaj.org/toc/2194-7511Abstract Objectives The early pathogenesis and precursors of Bipolar Disorder (BD) are poorly understood. There is some cross-sectional and retrospective evidence of affective lability as a predictor of BD, but this is subject to recall biases. The present review synthesises the prospective evidence examining affective lability and the subsequent development of BD at follow-up. Methods The authors performed a systematic search of PubMed, PsycInfo and Embase (1960–June 2020) and conducted hand searches to identify studies assessing affective lability (according to a conceptually-inclusive definition) at baseline assessment in individuals without a BD diagnosis, and a longitudinal follow-up assessment of bipolar (spectrum) disorders. Results are reported according to the PRISMA guidelines, and the synthesis without meta-analysis (SWiM) reporting guidelines were used to strengthen the narrative synthesis. The Newcastle–Ottawa Scale was used to assess risk of bias (ROB). Results 11 articles describing 10 studies were included. Being identified as having affective lability at baseline was associated with an increased rate of bipolar diagnoses at follow-up; this association was statistically significant in six of eight studies assessing BD type I/II at follow-up and in all four studies assessing for bipolar spectrum disorder (BSD) criteria. Most studies received a ‘fair’ or ‘poor’ ROB grade. Conclusions Despite a paucity of studies, an overall association between prospectively-identified affective lability and a later diagnosis of BD or BSD is apparent with relative consistency between studies. This association and further longitudinal studies could inform future clinical screening of those who may be at risk of BD, with the potential to improve diagnostic accuracy and facilitate early intervention.Rosie H. TaylorAndrea UlrichsenAllan H. YoungRebecca StrawbridgeSpringerOpenarticleBipolar disorderSystematic reviewAffective labilityMood instabilityProspectivePredictorNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurophysiology and neuropsychologyQP351-495ENInternational Journal of Bipolar Disorders, Vol 9, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bipolar disorder Systematic review Affective lability Mood instability Prospective Predictor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Bipolar disorder Systematic review Affective lability Mood instability Prospective Predictor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495 Rosie H. Taylor Andrea Ulrichsen Allan H. Young Rebecca Strawbridge Affective lability as a prospective predictor of subsequent bipolar disorder diagnosis: a systematic review
description	Abstract Objectives The early pathogenesis and precursors of Bipolar Disorder (BD) are poorly understood. There is some cross-sectional and retrospective evidence of affective lability as a predictor of BD, but this is subject to recall biases. The present review synthesises the prospective evidence examining affective lability and the subsequent development of BD at follow-up. Methods The authors performed a systematic search of PubMed, PsycInfo and Embase (1960–June 2020) and conducted hand searches to identify studies assessing affective lability (according to a conceptually-inclusive definition) at baseline assessment in individuals without a BD diagnosis, and a longitudinal follow-up assessment of bipolar (spectrum) disorders. Results are reported according to the PRISMA guidelines, and the synthesis without meta-analysis (SWiM) reporting guidelines were used to strengthen the narrative synthesis. The Newcastle–Ottawa Scale was used to assess risk of bias (ROB). Results 11 articles describing 10 studies were included. Being identified as having affective lability at baseline was associated with an increased rate of bipolar diagnoses at follow-up; this association was statistically significant in six of eight studies assessing BD type I/II at follow-up and in all four studies assessing for bipolar spectrum disorder (BSD) criteria. Most studies received a ‘fair’ or ‘poor’ ROB grade. Conclusions Despite a paucity of studies, an overall association between prospectively-identified affective lability and a later diagnosis of BD or BSD is apparent with relative consistency between studies. This association and further longitudinal studies could inform future clinical screening of those who may be at risk of BD, with the potential to improve diagnostic accuracy and facilitate early intervention.
format	article
author	Rosie H. Taylor Andrea Ulrichsen Allan H. Young Rebecca Strawbridge
author_facet	Rosie H. Taylor Andrea Ulrichsen Allan H. Young Rebecca Strawbridge
author_sort	Rosie H. Taylor
title	Affective lability as a prospective predictor of subsequent bipolar disorder diagnosis: a systematic review
title_short	Affective lability as a prospective predictor of subsequent bipolar disorder diagnosis: a systematic review
title_full	Affective lability as a prospective predictor of subsequent bipolar disorder diagnosis: a systematic review
title_fullStr	Affective lability as a prospective predictor of subsequent bipolar disorder diagnosis: a systematic review
title_full_unstemmed	Affective lability as a prospective predictor of subsequent bipolar disorder diagnosis: a systematic review
title_sort	affective lability as a prospective predictor of subsequent bipolar disorder diagnosis: a systematic review
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/af23b21484554302884c749f9230e65c
work_keys_str_mv	AT rosiehtaylor affectivelabilityasaprospectivepredictorofsubsequentbipolardisorderdiagnosisasystematicreview AT andreaulrichsen affectivelabilityasaprospectivepredictorofsubsequentbipolardisorderdiagnosisasystematicreview AT allanhyoung affectivelabilityasaprospectivepredictorofsubsequentbipolardisorderdiagnosisasystematicreview AT rebeccastrawbridge affectivelabilityasaprospectivepredictorofsubsequentbipolardisorderdiagnosisasystematicreview
_version_	1718442652965273600

Affective lability as a prospective predictor of subsequent bipolar disorder diagnosis: a systematic review

Ejemplares similares