Masaoka-Koga and TNM Staging System in Thymic Epithelial Tumors: Prognostic Comparison and the Role of the Number of Involved Structures

Background: The aim of this study was to evaluate the Masaoka–Koga and the tumor node metastases (TNM) staging system in thymic epithelial tumors (TET) considering possible improvements. Methods: We reviewed the data of 379 patients who underwent surgical resection for TET from 1 January 1985 to 1 J...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Marco Chiappetta, Filippo Lococo, Luca Pogliani, Isabella Sperduti, Diomira Tabacco, Emilio Bria, Ettore D’Argento, Mariangela Massaccesi, Luca Boldrini, Elisa Meacci, Venanzio Porziella, Dania Nachira, Maria Teresa Congedo, Stefano Margaritora
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	thymoma thymic carcinoma Masaoka–Koga TNM surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/af26c1dfc6064d20a2b9b0680e8b6561
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:af26c1dfc6064d20a2b9b0680e8b6561
record_format	dspace
spelling	oai:doaj.org-article:af26c1dfc6064d20a2b9b0680e8b65612021-11-11T15:26:22ZMasaoka-Koga and TNM Staging System in Thymic Epithelial Tumors: Prognostic Comparison and the Role of the Number of Involved Structures10.3390/cancers132152542072-6694https://doaj.org/article/af26c1dfc6064d20a2b9b0680e8b65612021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5254https://doaj.org/toc/2072-6694Background: The aim of this study was to evaluate the Masaoka–Koga and the tumor node metastases (TNM) staging system in thymic epithelial tumors (TET) considering possible improvements. Methods: We reviewed the data of 379 patients who underwent surgical resection for TET from 1 January 1985 to 1 January 2018, collecting and classifying the pathological report according to the Masaoka–Koga and the TMN system. The number of involved organs was also considered as a possible prognostic factor and integrated in the two staging systems to verify its impact. Results: Considering the Masaoka–Koga system, 5- and 10-year overall survival (5–10YOS) was 96.4% and 88.9% in stage I, 95% and 89.5% in stage II and 85.4% and 72.8% in stage III (<i>p =</i> 0.01), with overlapping in stage I and stage II curves. Considering the TNM system, 5–10YOS was 95.5% and 88.8% in T1, 84.8% and 70.7% in T2 and 88% and 76.3% in T3 (<i>p =</i> 0.02), with overlapping T2–T3 curves. Including the number of involved structures, in Masaoka–Koga stage III, patients with singular involved organs had a 100% and 76.6% vs. 87.7% 5–10YOS, which was 76.6% in patients with multiple organ infiltration. Considering the TNM, T3 patients with singular involved structures presented a 5–10YOS of 100% vs. 62.5% and 37.5% in patients with multiple organ involvement (<i>p =</i> 0.07). Conclusion: The two staging systems present limitations due to overlapping curves in early Masaoka–Koga stages and in advanced T stages for TNM. The addition of the number of involved organs seems to be a promising factor for the prognosis stratification in these patients.Marco ChiappettaFilippo LococoLuca PoglianiIsabella SperdutiDiomira TabaccoEmilio BriaEttore D’ArgentoMariangela MassaccesiLuca BoldriniElisa MeacciVenanzio PorziellaDania NachiraMaria Teresa CongedoStefano MargaritoraMDPI AGarticlethymomathymic carcinomaMasaoka–KogaTNMsurgeryNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5254, p 5254 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thymoma thymic carcinoma Masaoka–Koga TNM surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	thymoma thymic carcinoma Masaoka–Koga TNM surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Marco Chiappetta Filippo Lococo Luca Pogliani Isabella Sperduti Diomira Tabacco Emilio Bria Ettore D’Argento Mariangela Massaccesi Luca Boldrini Elisa Meacci Venanzio Porziella Dania Nachira Maria Teresa Congedo Stefano Margaritora Masaoka-Koga and TNM Staging System in Thymic Epithelial Tumors: Prognostic Comparison and the Role of the Number of Involved Structures
description	Background: The aim of this study was to evaluate the Masaoka–Koga and the tumor node metastases (TNM) staging system in thymic epithelial tumors (TET) considering possible improvements. Methods: We reviewed the data of 379 patients who underwent surgical resection for TET from 1 January 1985 to 1 January 2018, collecting and classifying the pathological report according to the Masaoka–Koga and the TMN system. The number of involved organs was also considered as a possible prognostic factor and integrated in the two staging systems to verify its impact. Results: Considering the Masaoka–Koga system, 5- and 10-year overall survival (5–10YOS) was 96.4% and 88.9% in stage I, 95% and 89.5% in stage II and 85.4% and 72.8% in stage III (<i>p =</i> 0.01), with overlapping in stage I and stage II curves. Considering the TNM system, 5–10YOS was 95.5% and 88.8% in T1, 84.8% and 70.7% in T2 and 88% and 76.3% in T3 (<i>p =</i> 0.02), with overlapping T2–T3 curves. Including the number of involved structures, in Masaoka–Koga stage III, patients with singular involved organs had a 100% and 76.6% vs. 87.7% 5–10YOS, which was 76.6% in patients with multiple organ infiltration. Considering the TNM, T3 patients with singular involved structures presented a 5–10YOS of 100% vs. 62.5% and 37.5% in patients with multiple organ involvement (<i>p =</i> 0.07). Conclusion: The two staging systems present limitations due to overlapping curves in early Masaoka–Koga stages and in advanced T stages for TNM. The addition of the number of involved organs seems to be a promising factor for the prognosis stratification in these patients.
format	article
author	Marco Chiappetta Filippo Lococo Luca Pogliani Isabella Sperduti Diomira Tabacco Emilio Bria Ettore D’Argento Mariangela Massaccesi Luca Boldrini Elisa Meacci Venanzio Porziella Dania Nachira Maria Teresa Congedo Stefano Margaritora
author_facet	Marco Chiappetta Filippo Lococo Luca Pogliani Isabella Sperduti Diomira Tabacco Emilio Bria Ettore D’Argento Mariangela Massaccesi Luca Boldrini Elisa Meacci Venanzio Porziella Dania Nachira Maria Teresa Congedo Stefano Margaritora
author_sort	Marco Chiappetta
title	Masaoka-Koga and TNM Staging System in Thymic Epithelial Tumors: Prognostic Comparison and the Role of the Number of Involved Structures
title_short	Masaoka-Koga and TNM Staging System in Thymic Epithelial Tumors: Prognostic Comparison and the Role of the Number of Involved Structures
title_full	Masaoka-Koga and TNM Staging System in Thymic Epithelial Tumors: Prognostic Comparison and the Role of the Number of Involved Structures
title_fullStr	Masaoka-Koga and TNM Staging System in Thymic Epithelial Tumors: Prognostic Comparison and the Role of the Number of Involved Structures
title_full_unstemmed	Masaoka-Koga and TNM Staging System in Thymic Epithelial Tumors: Prognostic Comparison and the Role of the Number of Involved Structures
title_sort	masaoka-koga and tnm staging system in thymic epithelial tumors: prognostic comparison and the role of the number of involved structures
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/af26c1dfc6064d20a2b9b0680e8b6561
work_keys_str_mv	AT marcochiappetta masaokakogaandtnmstagingsysteminthymicepithelialtumorsprognosticcomparisonandtheroleofthenumberofinvolvedstructures AT filippolococo masaokakogaandtnmstagingsysteminthymicepithelialtumorsprognosticcomparisonandtheroleofthenumberofinvolvedstructures AT lucapogliani masaokakogaandtnmstagingsysteminthymicepithelialtumorsprognosticcomparisonandtheroleofthenumberofinvolvedstructures AT isabellasperduti masaokakogaandtnmstagingsysteminthymicepithelialtumorsprognosticcomparisonandtheroleofthenumberofinvolvedstructures AT diomiratabacco masaokakogaandtnmstagingsysteminthymicepithelialtumorsprognosticcomparisonandtheroleofthenumberofinvolvedstructures AT emiliobria masaokakogaandtnmstagingsysteminthymicepithelialtumorsprognosticcomparisonandtheroleofthenumberofinvolvedstructures AT ettoredargento masaokakogaandtnmstagingsysteminthymicepithelialtumorsprognosticcomparisonandtheroleofthenumberofinvolvedstructures AT mariangelamassaccesi masaokakogaandtnmstagingsysteminthymicepithelialtumorsprognosticcomparisonandtheroleofthenumberofinvolvedstructures AT lucaboldrini masaokakogaandtnmstagingsysteminthymicepithelialtumorsprognosticcomparisonandtheroleofthenumberofinvolvedstructures AT elisameacci masaokakogaandtnmstagingsysteminthymicepithelialtumorsprognosticcomparisonandtheroleofthenumberofinvolvedstructures AT venanzioporziella masaokakogaandtnmstagingsysteminthymicepithelialtumorsprognosticcomparisonandtheroleofthenumberofinvolvedstructures AT danianachira masaokakogaandtnmstagingsysteminthymicepithelialtumorsprognosticcomparisonandtheroleofthenumberofinvolvedstructures AT mariateresacongedo masaokakogaandtnmstagingsysteminthymicepithelialtumorsprognosticcomparisonandtheroleofthenumberofinvolvedstructures AT stefanomargaritora masaokakogaandtnmstagingsysteminthymicepithelialtumorsprognosticcomparisonandtheroleofthenumberofinvolvedstructures
_version_	1718435328010747904

Masaoka-Koga and TNM Staging System in Thymic Epithelial Tumors: Prognostic Comparison and the Role of the Number of Involved Structures

Ejemplares similares