Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder

<sup>123</sup>I-metaiodobenzylguanidine (MIBG) cardiac scintigraphy was performed to assess cardiac autonomic dysfunction and demonstrate its correlation with clinical and polysomnographic characteristics in patients with isolated rapid eye movement (REM) sleep behavior disorder. All sub...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sooyeoun You, Kyoung Sook Won, Keun Tae Kim, Hyang Woon Lee, Yong Won Cho
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	REM sleep behavior disorder (RBD) sleep autonomic dysfunction <sup>123</sup>I-metaiodobenzylguanidine (MIBG) scintigraphy REM sleep without atonia Medicine R
Acceso en línea:	https://doaj.org/article/af2e6d3396cd4352934127ec6ba2f9c4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:af2e6d3396cd4352934127ec6ba2f9c4
record_format	dspace
spelling	oai:doaj.org-article:af2e6d3396cd4352934127ec6ba2f9c42021-11-25T18:02:34ZCardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder10.3390/jcm102254142077-0383https://doaj.org/article/af2e6d3396cd4352934127ec6ba2f9c42021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5414https://doaj.org/toc/2077-0383<sup>123</sup>I-metaiodobenzylguanidine (MIBG) cardiac scintigraphy was performed to assess cardiac autonomic dysfunction and demonstrate its correlation with clinical and polysomnographic characteristics in patients with isolated rapid eye movement (REM) sleep behavior disorder. All subjects including 39 patients with isolated REM sleep behavior disorder and 17 healthy controls underwent MIBG cardiac scintigraphy for cardiac autonomic dysfunction assessment. The isolated REM sleep behavior disorder was confirmed by in-lab overnight polysomnography. A receiver operating curve was constructed to determine the cut-off value of the early and delayed heart-to-mediastinum ratio in patients with isolated REM sleep behavior disorder. Based on each cut-off value, a comparison analysis of REM sleep without atonia was performed by dividing isolated REM sleep behavior disorder patients into two groups. MIBG uptake below the cut-off value was associated with higher REM sleep without atonia. The lower heart-to-mediastinum ratio had significantly higher REM sleep without atonia (%), both with cut-off values of early (11.0 ± 5.6 vs. 29.3 ± 23.2%, <i>p</i> = 0.018) and delayed heart-to-mediastinum ratio (9.1 ± 4.3 vs. 30.0 ± 22.9%, <i>p</i> = 0.011). These findings indicate that reduced MIBG uptake is associated with higher REM sleep without atonia in isolated REM sleep behavior disorder.Sooyeoun YouKyoung Sook WonKeun Tae KimHyang Woon LeeYong Won ChoMDPI AGarticleREM sleep behavior disorder (RBD)sleepautonomic dysfunction<sup>123</sup>I-metaiodobenzylguanidine (MIBG) scintigraphyREM sleep without atoniaMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5414, p 5414 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	REM sleep behavior disorder (RBD) sleep autonomic dysfunction <sup>123</sup>I-metaiodobenzylguanidine (MIBG) scintigraphy REM sleep without atonia Medicine R
spellingShingle	REM sleep behavior disorder (RBD) sleep autonomic dysfunction <sup>123</sup>I-metaiodobenzylguanidine (MIBG) scintigraphy REM sleep without atonia Medicine R Sooyeoun You Kyoung Sook Won Keun Tae Kim Hyang Woon Lee Yong Won Cho Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder
description	<sup>123</sup>I-metaiodobenzylguanidine (MIBG) cardiac scintigraphy was performed to assess cardiac autonomic dysfunction and demonstrate its correlation with clinical and polysomnographic characteristics in patients with isolated rapid eye movement (REM) sleep behavior disorder. All subjects including 39 patients with isolated REM sleep behavior disorder and 17 healthy controls underwent MIBG cardiac scintigraphy for cardiac autonomic dysfunction assessment. The isolated REM sleep behavior disorder was confirmed by in-lab overnight polysomnography. A receiver operating curve was constructed to determine the cut-off value of the early and delayed heart-to-mediastinum ratio in patients with isolated REM sleep behavior disorder. Based on each cut-off value, a comparison analysis of REM sleep without atonia was performed by dividing isolated REM sleep behavior disorder patients into two groups. MIBG uptake below the cut-off value was associated with higher REM sleep without atonia. The lower heart-to-mediastinum ratio had significantly higher REM sleep without atonia (%), both with cut-off values of early (11.0 ± 5.6 vs. 29.3 ± 23.2%, <i>p</i> = 0.018) and delayed heart-to-mediastinum ratio (9.1 ± 4.3 vs. 30.0 ± 22.9%, <i>p</i> = 0.011). These findings indicate that reduced MIBG uptake is associated with higher REM sleep without atonia in isolated REM sleep behavior disorder.
format	article
author	Sooyeoun You Kyoung Sook Won Keun Tae Kim Hyang Woon Lee Yong Won Cho
author_facet	Sooyeoun You Kyoung Sook Won Keun Tae Kim Hyang Woon Lee Yong Won Cho
author_sort	Sooyeoun You
title	Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder
title_short	Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder
title_full	Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder
title_fullStr	Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder
title_full_unstemmed	Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder
title_sort	cardiac autonomic dysfunction is associated with severity of rem sleep without atonia in isolated rem sleep behavior disorder
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/af2e6d3396cd4352934127ec6ba2f9c4
work_keys_str_mv	AT sooyeounyou cardiacautonomicdysfunctionisassociatedwithseverityofremsleepwithoutatoniainisolatedremsleepbehaviordisorder AT kyoungsookwon cardiacautonomicdysfunctionisassociatedwithseverityofremsleepwithoutatoniainisolatedremsleepbehaviordisorder AT keuntaekim cardiacautonomicdysfunctionisassociatedwithseverityofremsleepwithoutatoniainisolatedremsleepbehaviordisorder AT hyangwoonlee cardiacautonomicdysfunctionisassociatedwithseverityofremsleepwithoutatoniainisolatedremsleepbehaviordisorder AT yongwoncho cardiacautonomicdysfunctionisassociatedwithseverityofremsleepwithoutatoniainisolatedremsleepbehaviordisorder
_version_	1718411701198520320

Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder

Ejemplares similares