Exosomes: Novel Bio-Inspired Nanocarriers for Efficient Targeting of Glioblastoma Tumor Cells

BACKGROUND AND OBJECTIVE: Glioblastoma is a highly malignant brain tumor that is characterized by poor prognosis and high recurrence rate in patients. Surgery, chemotherapy and radiotherapy are considered as standard methods of glioblastoma treatment. However, these methods have not been able to com...

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Autores principales:	V Taghdiri Nooshabadi, S Arab, Z Taghdiri Nooshabadi
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2021
Materias:	exosome nanocarrier glioblastoma. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/af2f7bf32bb64cf5880bc1e1d7dd55a9
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spelling	oai:doaj.org-article:af2f7bf32bb64cf5880bc1e1d7dd55a92021-11-29T07:40:49ZExosomes: Novel Bio-Inspired Nanocarriers for Efficient Targeting of Glioblastoma Tumor Cells1561-41072251-7170https://doaj.org/article/af2f7bf32bb64cf5880bc1e1d7dd55a92021-03-01T00:00:00Zhttp://jbums.org/article-1-9338-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Glioblastoma is a highly malignant brain tumor that is characterized by poor prognosis and high recurrence rate in patients. Surgery, chemotherapy and radiotherapy are considered as standard methods of glioblastoma treatment. However, these methods have not been able to completely kill cancer cells. One of the most important barriers to the treatment of glioblastoma is the blood-brain barrier, which prevents drugs from reaching the brain tissue. The aim of this study was to investigate the possibility of using exosomes as drug carriers in the treatment of glioblastoma tumor. METHODS: In this review article, we searched Google Scholar and Pub Med databases using the keyword “exosomes”, “glioblastomas”, and “drug delivery systems” to provide an overview of exosomes as an opportunity for the delivery of drug into the central nervous system through the blood-brain barrier. FINDINGS: In the initial search, 14400 articles were found, and after an initial review and removal of unrelated studies, 40 articles were finally reviewed. Exosomes are natural nanoparticles that are secreted from different cells. Using exosomes in drug delivery systems is an efficient approach for transferring various contents to cancer cells. These particles are also able to transfer biological and drug molecules from the blood-brain barrier to brain cells. These natural nanoparticles are stable with long circulations that do not cause immune rejection responses. CONCLUSION: According to the results of this study, as a potential carrier with very interesting and attractive advantages in drug delivery and transfer of drug agents, exosome-based nanocarriers can be used to treat brain tumors such as glioblastoma multiforme.V Taghdiri NooshabadiS ArabZ Taghdiri NooshabadiBabol University of Medical Sciencesarticleexosomenanocarrierglioblastoma.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 23, Iss 1, Pp 16-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	exosome nanocarrier glioblastoma. Medicine R Medicine (General) R5-920
spellingShingle	exosome nanocarrier glioblastoma. Medicine R Medicine (General) R5-920 V Taghdiri Nooshabadi S Arab Z Taghdiri Nooshabadi Exosomes: Novel Bio-Inspired Nanocarriers for Efficient Targeting of Glioblastoma Tumor Cells
description	BACKGROUND AND OBJECTIVE: Glioblastoma is a highly malignant brain tumor that is characterized by poor prognosis and high recurrence rate in patients. Surgery, chemotherapy and radiotherapy are considered as standard methods of glioblastoma treatment. However, these methods have not been able to completely kill cancer cells. One of the most important barriers to the treatment of glioblastoma is the blood-brain barrier, which prevents drugs from reaching the brain tissue. The aim of this study was to investigate the possibility of using exosomes as drug carriers in the treatment of glioblastoma tumor. METHODS: In this review article, we searched Google Scholar and Pub Med databases using the keyword “exosomes”, “glioblastomas”, and “drug delivery systems” to provide an overview of exosomes as an opportunity for the delivery of drug into the central nervous system through the blood-brain barrier. FINDINGS: In the initial search, 14400 articles were found, and after an initial review and removal of unrelated studies, 40 articles were finally reviewed. Exosomes are natural nanoparticles that are secreted from different cells. Using exosomes in drug delivery systems is an efficient approach for transferring various contents to cancer cells. These particles are also able to transfer biological and drug molecules from the blood-brain barrier to brain cells. These natural nanoparticles are stable with long circulations that do not cause immune rejection responses. CONCLUSION: According to the results of this study, as a potential carrier with very interesting and attractive advantages in drug delivery and transfer of drug agents, exosome-based nanocarriers can be used to treat brain tumors such as glioblastoma multiforme.
format	article
author	V Taghdiri Nooshabadi S Arab Z Taghdiri Nooshabadi
author_facet	V Taghdiri Nooshabadi S Arab Z Taghdiri Nooshabadi
author_sort	V Taghdiri Nooshabadi
title	Exosomes: Novel Bio-Inspired Nanocarriers for Efficient Targeting of Glioblastoma Tumor Cells
title_short	Exosomes: Novel Bio-Inspired Nanocarriers for Efficient Targeting of Glioblastoma Tumor Cells
title_full	Exosomes: Novel Bio-Inspired Nanocarriers for Efficient Targeting of Glioblastoma Tumor Cells
title_fullStr	Exosomes: Novel Bio-Inspired Nanocarriers for Efficient Targeting of Glioblastoma Tumor Cells
title_full_unstemmed	Exosomes: Novel Bio-Inspired Nanocarriers for Efficient Targeting of Glioblastoma Tumor Cells
title_sort	exosomes: novel bio-inspired nanocarriers for efficient targeting of glioblastoma tumor cells
publisher	Babol University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/af2f7bf32bb64cf5880bc1e1d7dd55a9
work_keys_str_mv	AT vtaghdirinooshabadi exosomesnovelbioinspirednanocarriersforefficienttargetingofglioblastomatumorcells AT sarab exosomesnovelbioinspirednanocarriersforefficienttargetingofglioblastomatumorcells AT ztaghdirinooshabadi exosomesnovelbioinspirednanocarriersforefficienttargetingofglioblastomatumorcells
_version_	1718407545243041792

Exosomes: Novel Bio-Inspired Nanocarriers for Efficient Targeting of Glioblastoma Tumor Cells

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