Estrogen receptor β activation impairs prostatic regeneration by inducing apoptosis in murine and human stem/progenitor enriched cell populations.

Androgen depletion is the primary treatment for prostate disease; however, it fails to target residual castrate-resistant cells that are regenerative and cells of origin of prostate cancer. Estrogens, like androgens, regulate survival in prostatic cells, and the goal of this study was to determine t...

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Autores principales: Shirin Hussain, Mitchell G Lawrence, Renea A Taylor, Camden Yeung-Wah Lo, APC BioResource, Mark Frydenberg, Stuart J Ellem, Luc Furic, Gail P Risbridger
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/af2fe4a94dca42c6bb0b8c712ee49467
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