Isolation and genetic characterization of a relapsing fever spirochete isolated from Ornithodoros puertoricensis collected in central Panama.

Tick-borne relapsing fever (TBRF) spirochetes are likely an overlooked cause of disease in Latin America. In Panama, the pathogens were first reported to cause human disease in the early 1900s. Recent collections of Ornithodoros puertoricensis from human dwellings in Panama prompted our interest to...

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Autores principales:	Sergio E Bermúdez, Brittany A Armstrong, Lillian Domínguez, Aparna Krishnavajhala, Alexander R Kneubehl, Sarah M Gunter, Adam Replogle, Jeannine M Petersen, Job E Lopez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/af310e26220648fda08db10a8133a991
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spelling	oai:doaj.org-article:af310e26220648fda08db10a8133a9912021-12-02T20:23:39ZIsolation and genetic characterization of a relapsing fever spirochete isolated from Ornithodoros puertoricensis collected in central Panama.1935-27271935-273510.1371/journal.pntd.0009642https://doaj.org/article/af310e26220648fda08db10a8133a9912021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009642https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Tick-borne relapsing fever (TBRF) spirochetes are likely an overlooked cause of disease in Latin America. In Panama, the pathogens were first reported to cause human disease in the early 1900s. Recent collections of Ornithodoros puertoricensis from human dwellings in Panama prompted our interest to determine whether spirochetes still circulate in the country. Ornithodoros puertoricensis ticks were collected at field sites around the City of Panama. In the laboratory, the ticks were determined to be infected with TBRF spirochetes by transmission to mice, and we report the laboratory isolation and genetic characterization of a species of TBRF spirochete from Panama. Since this was the first isolation of a species of TBRF spirochete from Central America, we propose to designate the bacteria as Borrelia puertoricensis sp. nov. This is consistent with TBRF spirochete species nomenclature from North America that are designated after their tick vector. These findings warrant further investigations to assess the threat B. puertoricensis sp. nov. may impose on human health.Sergio E BermúdezBrittany A ArmstrongLillian DomínguezAparna KrishnavajhalaAlexander R KneubehlSarah M GunterAdam ReplogleJeannine M PetersenJob E LopezPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009642 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sergio E Bermúdez Brittany A Armstrong Lillian Domínguez Aparna Krishnavajhala Alexander R Kneubehl Sarah M Gunter Adam Replogle Jeannine M Petersen Job E Lopez Isolation and genetic characterization of a relapsing fever spirochete isolated from Ornithodoros puertoricensis collected in central Panama.
description	Tick-borne relapsing fever (TBRF) spirochetes are likely an overlooked cause of disease in Latin America. In Panama, the pathogens were first reported to cause human disease in the early 1900s. Recent collections of Ornithodoros puertoricensis from human dwellings in Panama prompted our interest to determine whether spirochetes still circulate in the country. Ornithodoros puertoricensis ticks were collected at field sites around the City of Panama. In the laboratory, the ticks were determined to be infected with TBRF spirochetes by transmission to mice, and we report the laboratory isolation and genetic characterization of a species of TBRF spirochete from Panama. Since this was the first isolation of a species of TBRF spirochete from Central America, we propose to designate the bacteria as Borrelia puertoricensis sp. nov. This is consistent with TBRF spirochete species nomenclature from North America that are designated after their tick vector. These findings warrant further investigations to assess the threat B. puertoricensis sp. nov. may impose on human health.
format	article
author	Sergio E Bermúdez Brittany A Armstrong Lillian Domínguez Aparna Krishnavajhala Alexander R Kneubehl Sarah M Gunter Adam Replogle Jeannine M Petersen Job E Lopez
author_facet	Sergio E Bermúdez Brittany A Armstrong Lillian Domínguez Aparna Krishnavajhala Alexander R Kneubehl Sarah M Gunter Adam Replogle Jeannine M Petersen Job E Lopez
author_sort	Sergio E Bermúdez
title	Isolation and genetic characterization of a relapsing fever spirochete isolated from Ornithodoros puertoricensis collected in central Panama.
title_short	Isolation and genetic characterization of a relapsing fever spirochete isolated from Ornithodoros puertoricensis collected in central Panama.
title_full	Isolation and genetic characterization of a relapsing fever spirochete isolated from Ornithodoros puertoricensis collected in central Panama.
title_fullStr	Isolation and genetic characterization of a relapsing fever spirochete isolated from Ornithodoros puertoricensis collected in central Panama.
title_full_unstemmed	Isolation and genetic characterization of a relapsing fever spirochete isolated from Ornithodoros puertoricensis collected in central Panama.
title_sort	isolation and genetic characterization of a relapsing fever spirochete isolated from ornithodoros puertoricensis collected in central panama.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/af310e26220648fda08db10a8133a991
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Isolation and genetic characterization of a relapsing fever spirochete isolated from Ornithodoros puertoricensis collected in central Panama.

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