Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats
Abstract Exposed rats to normal saline and paraquat (PQ) aerosol as control and PQ group, rats exposed to PQ and treated with 20 and 80 mg/kg/day carvacrol, 5 and 10 mg/kg/day pioglitazone, low dose of pioglitazone + carvacrol and 0.03 mg/kg/day dexamethasone (Dexa) for 16 days after the end of PQ e...
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Nature Portfolio
2021
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oai:doaj.org-article:af330fac8be643fda9a482bf4bfc57972021-12-02T15:51:15ZCarvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats10.1038/s41598-021-87546-82045-2322https://doaj.org/article/af330fac8be643fda9a482bf4bfc57972021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87546-8https://doaj.org/toc/2045-2322Abstract Exposed rats to normal saline and paraquat (PQ) aerosol as control and PQ group, rats exposed to PQ and treated with 20 and 80 mg/kg/day carvacrol, 5 and 10 mg/kg/day pioglitazone, low dose of pioglitazone + carvacrol and 0.03 mg/kg/day dexamethasone (Dexa) for 16 days after the end of PQ exposure were studied (n = 6 in each group). Lung pathological changes, tracheal responsiveness to methacholine and ovalbumin (OVA) as well as transforming growth factor beta (TGF-β) and interleukin (IL)-6 level in the lung tissue homogenize as well as TGF-β, IL-6, oxidant and antioxidant levels oxidant and antioxidants were increased in PQ group (p < 0.01 to p < 0.001). Lung pathological changes, tracheal responsiveness to methacholine and OVA as well as TGF-β, IL-6 oxidant and antioxidant levels were improved in all treated groups except lung pathological changes in treated group with low dose of pioglitazone (p < 0.05 to p < 0.001). The effects of low dose of pioglitazone and carvacrol alone were significantly lower than in the combination group of low dose of pioglitazone + carvacrol (p < 0.05 to p < 0.001). Carvacrol treatment improved inhaled PQ-induced lug injury similar to the effects of dexamethasone. The synergic effect of carvacrol and pioglitazone suggests PPAR-γ receptor mediated effects of carvacrol on inhaled PQ-induced lung injury.Fatemeh AminArghavan MemarziaHamideh Kazemi RadHamid Reza KazeraniMohammad Hossein BoskabadyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021) |
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Medicine R Science Q Fatemeh Amin Arghavan Memarzia Hamideh Kazemi Rad Hamid Reza Kazerani Mohammad Hossein Boskabady Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats |
| description |
Abstract Exposed rats to normal saline and paraquat (PQ) aerosol as control and PQ group, rats exposed to PQ and treated with 20 and 80 mg/kg/day carvacrol, 5 and 10 mg/kg/day pioglitazone, low dose of pioglitazone + carvacrol and 0.03 mg/kg/day dexamethasone (Dexa) for 16 days after the end of PQ exposure were studied (n = 6 in each group). Lung pathological changes, tracheal responsiveness to methacholine and ovalbumin (OVA) as well as transforming growth factor beta (TGF-β) and interleukin (IL)-6 level in the lung tissue homogenize as well as TGF-β, IL-6, oxidant and antioxidant levels oxidant and antioxidants were increased in PQ group (p < 0.01 to p < 0.001). Lung pathological changes, tracheal responsiveness to methacholine and OVA as well as TGF-β, IL-6 oxidant and antioxidant levels were improved in all treated groups except lung pathological changes in treated group with low dose of pioglitazone (p < 0.05 to p < 0.001). The effects of low dose of pioglitazone and carvacrol alone were significantly lower than in the combination group of low dose of pioglitazone + carvacrol (p < 0.05 to p < 0.001). Carvacrol treatment improved inhaled PQ-induced lug injury similar to the effects of dexamethasone. The synergic effect of carvacrol and pioglitazone suggests PPAR-γ receptor mediated effects of carvacrol on inhaled PQ-induced lung injury. |
| format |
article |
| author |
Fatemeh Amin Arghavan Memarzia Hamideh Kazemi Rad Hamid Reza Kazerani Mohammad Hossein Boskabady |
| author_facet |
Fatemeh Amin Arghavan Memarzia Hamideh Kazemi Rad Hamid Reza Kazerani Mohammad Hossein Boskabady |
| author_sort |
Fatemeh Amin |
| title |
Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats |
| title_short |
Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats |
| title_full |
Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats |
| title_fullStr |
Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats |
| title_full_unstemmed |
Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats |
| title_sort |
carvacrol and pparγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/af330fac8be643fda9a482bf4bfc5797 |
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