How air pollution alters brain development: the role of neuroinflammation

The present review synthesizes lines of emerging evidence showing how several samples of children populations living in large cities around the world suffer to some degree neural, behavioral and cognitive changes associated with air pollution exposure. The breakdown of natural barriers warding again...

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Autores principales:	Brockmeyer Sam, D’Angiulli Amedeo
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2016
Materias:	air pollution child brain development children's health early prevention and intervention neurodegeneration neuroinflammation public health Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/af33dbe20d9a4fff80f7388b4f7d2e8a
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spelling	oai:doaj.org-article:af33dbe20d9a4fff80f7388b4f7d2e8a2021-12-05T14:11:04ZHow air pollution alters brain development: the role of neuroinflammation2081-693610.1515/tnsci-2016-0005https://doaj.org/article/af33dbe20d9a4fff80f7388b4f7d2e8a2016-01-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2016-0005https://doaj.org/toc/2081-6936The present review synthesizes lines of emerging evidence showing how several samples of children populations living in large cities around the world suffer to some degree neural, behavioral and cognitive changes associated with air pollution exposure. The breakdown of natural barriers warding against the entry of toxic particles, including the nasal, gut and lung epithelial barriers, as well as widespread breakdown of the blood-brain barrier facilitatethe passage of airborne pollutants into the body of young urban residents. Extensive neuroinflammation contributes to cell loss within the central nervous system, and likely is a crucial mechanism by which cognitive deficits may arise. Although subtle, neurocognitive effects of air pollution are substantial, apparent across all populations, and potentially clinically relevant as early evidence of evolving neurodegenerative changes. The diffuse nature of the neuroinflammation risk suggests an integrated neuroscientific approach incorporating current clinical, cognitive, neurophysiological, radiological and epidemiologic research. Neuropediatric air pollution research requires extensive multidisciplinary collaborations to accomplish the goal of protecting exposed children through multidimensional interventions having both broad impact and reach. While intervening by improving environmental quality at a global scale is imperative, we also need to devise efficient strategies on how the neurocognitive effects on local pediatric populations should be monitored.Brockmeyer SamD’Angiulli AmedeoDe Gruyterarticleair pollutionchild brain developmentchildren's healthearly prevention and interventionneurodegenerationneuroinflammationpublic healthNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 7, Iss 1, Pp 24-30 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	air pollution child brain development children's health early prevention and intervention neurodegeneration neuroinflammation public health Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	air pollution child brain development children's health early prevention and intervention neurodegeneration neuroinflammation public health Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Brockmeyer Sam D’Angiulli Amedeo How air pollution alters brain development: the role of neuroinflammation
description	The present review synthesizes lines of emerging evidence showing how several samples of children populations living in large cities around the world suffer to some degree neural, behavioral and cognitive changes associated with air pollution exposure. The breakdown of natural barriers warding against the entry of toxic particles, including the nasal, gut and lung epithelial barriers, as well as widespread breakdown of the blood-brain barrier facilitatethe passage of airborne pollutants into the body of young urban residents. Extensive neuroinflammation contributes to cell loss within the central nervous system, and likely is a crucial mechanism by which cognitive deficits may arise. Although subtle, neurocognitive effects of air pollution are substantial, apparent across all populations, and potentially clinically relevant as early evidence of evolving neurodegenerative changes. The diffuse nature of the neuroinflammation risk suggests an integrated neuroscientific approach incorporating current clinical, cognitive, neurophysiological, radiological and epidemiologic research. Neuropediatric air pollution research requires extensive multidisciplinary collaborations to accomplish the goal of protecting exposed children through multidimensional interventions having both broad impact and reach. While intervening by improving environmental quality at a global scale is imperative, we also need to devise efficient strategies on how the neurocognitive effects on local pediatric populations should be monitored.
format	article
author	Brockmeyer Sam D’Angiulli Amedeo
author_facet	Brockmeyer Sam D’Angiulli Amedeo
author_sort	Brockmeyer Sam
title	How air pollution alters brain development: the role of neuroinflammation
title_short	How air pollution alters brain development: the role of neuroinflammation
title_full	How air pollution alters brain development: the role of neuroinflammation
title_fullStr	How air pollution alters brain development: the role of neuroinflammation
title_full_unstemmed	How air pollution alters brain development: the role of neuroinflammation
title_sort	how air pollution alters brain development: the role of neuroinflammation
publisher	De Gruyter
publishDate	2016
url	https://doaj.org/article/af33dbe20d9a4fff80f7388b4f7d2e8a
work_keys_str_mv	AT brockmeyersam howairpollutionaltersbraindevelopmenttheroleofneuroinflammation AT dangiulliamedeo howairpollutionaltersbraindevelopmenttheroleofneuroinflammation
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How air pollution alters brain development: the role of neuroinflammation

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