Serum syndecan-1 reflects organ dysfunction in critically ill patients

Abstract Syndecan-1 (SDC-1) is found in the endothelial glycocalyx and shed into the blood during systemic inflammatory conditions. We investigated organ dysfunction associated with changing serum SDC-1 levels for early detection of organ dysfunction in critically ill patients. To evaluate the effec...

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Autores principales: Keiko Suzuki, Hideshi Okada, Kazuyuki Sumi, Hiroyuki Tomita, Ryo Kobayashi, Takuma Ishihara, Yoshinori Kakino, Kodai Suzuki, Naomasa Yoshiyama, Ryu Yasuda, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Haruka Okamoto, Tomoaki Doi, Takahiro Yoshida, Shozo Yoshida, Shinji Ogura, Akio Suzuki
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/af37f7bf72324037a4a2453605026188
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spelling oai:doaj.org-article:af37f7bf72324037a4a24536050261882021-12-02T15:27:06ZSerum syndecan-1 reflects organ dysfunction in critically ill patients10.1038/s41598-021-88303-72045-2322https://doaj.org/article/af37f7bf72324037a4a24536050261882021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88303-7https://doaj.org/toc/2045-2322Abstract Syndecan-1 (SDC-1) is found in the endothelial glycocalyx and shed into the blood during systemic inflammatory conditions. We investigated organ dysfunction associated with changing serum SDC-1 levels for early detection of organ dysfunction in critically ill patients. To evaluate the effect of SDC-1 on laboratory parameters measured the day after SDC-1 measurement with consideration for repeated measures, linear mixed effects models were constructed with each parameter as an outcome variable. A total of 94 patients were enrolled, and 831 samples were obtained. Analysis using mixed effects models for repeated measures with adjustment for age and sex showed that serum SDC-1 levels measured the day before significantly affected several outcomes, including aspartate aminotransferase (AST), alanine transaminase (ALT), creatinine (CRE), blood urea nitrogen (BUN), antithrombin III, fibrin degradation products, and D-dimer. Moreover, serum SDC-1 levels of the prior day significantly modified the effect between time and several outcomes, including AST, ALT, CRE, and BUN. Additionally, increasing serum SDC-1 level was a significant risk factor for mortality. Serum SDC-1 may be a useful biomarker for daily monitoring to detect early signs of kidney, liver and coagulation system dysfunction, and may be an important risk factor for mortality in critically ill patients.Keiko SuzukiHideshi OkadaKazuyuki SumiHiroyuki TomitaRyo KobayashiTakuma IshiharaYoshinori KakinoKodai SuzukiNaomasa YoshiyamaRyu YasudaYuichiro KitagawaTetsuya FukutaTakahito MiyakeHaruka OkamotoTomoaki DoiTakahiro YoshidaShozo YoshidaShinji OguraAkio SuzukiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Keiko Suzuki
Hideshi Okada
Kazuyuki Sumi
Hiroyuki Tomita
Ryo Kobayashi
Takuma Ishihara
Yoshinori Kakino
Kodai Suzuki
Naomasa Yoshiyama
Ryu Yasuda
Yuichiro Kitagawa
Tetsuya Fukuta
Takahito Miyake
Haruka Okamoto
Tomoaki Doi
Takahiro Yoshida
Shozo Yoshida
Shinji Ogura
Akio Suzuki
Serum syndecan-1 reflects organ dysfunction in critically ill patients
description Abstract Syndecan-1 (SDC-1) is found in the endothelial glycocalyx and shed into the blood during systemic inflammatory conditions. We investigated organ dysfunction associated with changing serum SDC-1 levels for early detection of organ dysfunction in critically ill patients. To evaluate the effect of SDC-1 on laboratory parameters measured the day after SDC-1 measurement with consideration for repeated measures, linear mixed effects models were constructed with each parameter as an outcome variable. A total of 94 patients were enrolled, and 831 samples were obtained. Analysis using mixed effects models for repeated measures with adjustment for age and sex showed that serum SDC-1 levels measured the day before significantly affected several outcomes, including aspartate aminotransferase (AST), alanine transaminase (ALT), creatinine (CRE), blood urea nitrogen (BUN), antithrombin III, fibrin degradation products, and D-dimer. Moreover, serum SDC-1 levels of the prior day significantly modified the effect between time and several outcomes, including AST, ALT, CRE, and BUN. Additionally, increasing serum SDC-1 level was a significant risk factor for mortality. Serum SDC-1 may be a useful biomarker for daily monitoring to detect early signs of kidney, liver and coagulation system dysfunction, and may be an important risk factor for mortality in critically ill patients.
format article
author Keiko Suzuki
Hideshi Okada
Kazuyuki Sumi
Hiroyuki Tomita
Ryo Kobayashi
Takuma Ishihara
Yoshinori Kakino
Kodai Suzuki
Naomasa Yoshiyama
Ryu Yasuda
Yuichiro Kitagawa
Tetsuya Fukuta
Takahito Miyake
Haruka Okamoto
Tomoaki Doi
Takahiro Yoshida
Shozo Yoshida
Shinji Ogura
Akio Suzuki
author_facet Keiko Suzuki
Hideshi Okada
Kazuyuki Sumi
Hiroyuki Tomita
Ryo Kobayashi
Takuma Ishihara
Yoshinori Kakino
Kodai Suzuki
Naomasa Yoshiyama
Ryu Yasuda
Yuichiro Kitagawa
Tetsuya Fukuta
Takahito Miyake
Haruka Okamoto
Tomoaki Doi
Takahiro Yoshida
Shozo Yoshida
Shinji Ogura
Akio Suzuki
author_sort Keiko Suzuki
title Serum syndecan-1 reflects organ dysfunction in critically ill patients
title_short Serum syndecan-1 reflects organ dysfunction in critically ill patients
title_full Serum syndecan-1 reflects organ dysfunction in critically ill patients
title_fullStr Serum syndecan-1 reflects organ dysfunction in critically ill patients
title_full_unstemmed Serum syndecan-1 reflects organ dysfunction in critically ill patients
title_sort serum syndecan-1 reflects organ dysfunction in critically ill patients
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/af37f7bf72324037a4a2453605026188
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