Tumor mutation burden forecasts outcome in ovarian cancer with BRCA1 or BRCA2 mutations.

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Tumor mutation burden forecasts outcome in ovarian cancer with BRCA1 or BRCA2 mutations.

<h4>Background</h4>Increased number of single nucleotide substitutions is seen in breast and ovarian cancer genomes carrying disease-associated mutations in BRCA1 or BRCA2. The significance of these genome-wide mutations is unknown. We hypothesize genome-wide mutation burden mirrors defi...

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Détails bibliographiques
Auteurs principaux:	Nicolai Juul Birkbak, Bose Kochupurakkal, Jose M G Izarzugaza, Aron C Eklund, Yang Li, Joyce Liu, Zoltan Szallasi, Ursula A Matulonis, Andrea L Richardson, J Dirk Iglehart, Zhigang C Wang
Format:	article
Langue:	EN
Publié:	Public Library of Science (PLoS) 2013
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/af39aee1554b495da94db92c355a9275
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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