Entacapone reduces cortical activation in Parkinson's disease with wearing-off: a f-MRI study.

<h4>Background and purpose</h4>Wearing-off is one of the most frequent problems encountered by levodopa-treated patients. Entacapone, a peripheral inhibitor of catechol-O-methyltransferase (COMT), reduces this motor complication by prolonging the effect of levodopa. We sought to understa...

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Autores principales:	Nicola Tambasco, Marco Muti, Pietro Chiarini, Roberto Tarducci, Stefano Caproni, Anna Castrioto, Pasquale Nigro, Lucilla Parnetti, Pietro Floridi, Aroldo Rossi, Paolo Calabresi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/af39b1d1cef64071ab39c349b1eb0fb5
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spelling	oai:doaj.org-article:af39b1d1cef64071ab39c349b1eb0fb52021-11-18T08:19:14ZEntacapone reduces cortical activation in Parkinson's disease with wearing-off: a f-MRI study.1932-620310.1371/journal.pone.0096806https://doaj.org/article/af39b1d1cef64071ab39c349b1eb0fb52014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24830331/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and purpose</h4>Wearing-off is one of the most frequent problems encountered by levodopa-treated patients. Entacapone, a peripheral inhibitor of catechol-O-methyltransferase (COMT), reduces this motor complication by prolonging the effect of levodopa. We sought to understand the impact of COMT-inhibition on movement execution in PD patients with wearing-off by comparing functional magnetic resonance imaging (f-MRI) activation patterns prior to and during entacapone treatment. Our hypothesis was to determine whether changes in cortical activation are associated to COMT-inhibitor treatment.<h4>Methods</h4>Nine levodopa-treated non-demented PD patients with wearing-off were prospectively studied in two f-MRI session, prior to and during entacapone treatment. A group of control subjects were also studied for comparison.<h4>Results</h4>The patients significantly improved under COMT-inhibitor treatment based on home diaries. F-MRI results showed that at baseline the patients presented a bilateral activation of the primary motor, controlateral premotor cortex and supplementary motor area, as well as ipsilateral cerebellum. During treatment with entacapone, PD patients showed reductions in the activations of these cortical areas and a decreased activation in the ipsilateral cerebellum.<h4>Conclusions</h4>Our preliminary findings indicate that f-MRI is able to detect cortical activation changes during long-term modulation of dopaminergic treatment in PD patients with wearing-off, and thus, this technique could be further investigated in advanced PD patients.Nicola TambascoMarco MutiPietro ChiariniRoberto TarducciStefano CaproniAnna CastriotoPasquale NigroLucilla ParnettiPietro FloridiAroldo RossiPaolo CalabresiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e96806 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nicola Tambasco Marco Muti Pietro Chiarini Roberto Tarducci Stefano Caproni Anna Castrioto Pasquale Nigro Lucilla Parnetti Pietro Floridi Aroldo Rossi Paolo Calabresi Entacapone reduces cortical activation in Parkinson's disease with wearing-off: a f-MRI study.
description	<h4>Background and purpose</h4>Wearing-off is one of the most frequent problems encountered by levodopa-treated patients. Entacapone, a peripheral inhibitor of catechol-O-methyltransferase (COMT), reduces this motor complication by prolonging the effect of levodopa. We sought to understand the impact of COMT-inhibition on movement execution in PD patients with wearing-off by comparing functional magnetic resonance imaging (f-MRI) activation patterns prior to and during entacapone treatment. Our hypothesis was to determine whether changes in cortical activation are associated to COMT-inhibitor treatment.<h4>Methods</h4>Nine levodopa-treated non-demented PD patients with wearing-off were prospectively studied in two f-MRI session, prior to and during entacapone treatment. A group of control subjects were also studied for comparison.<h4>Results</h4>The patients significantly improved under COMT-inhibitor treatment based on home diaries. F-MRI results showed that at baseline the patients presented a bilateral activation of the primary motor, controlateral premotor cortex and supplementary motor area, as well as ipsilateral cerebellum. During treatment with entacapone, PD patients showed reductions in the activations of these cortical areas and a decreased activation in the ipsilateral cerebellum.<h4>Conclusions</h4>Our preliminary findings indicate that f-MRI is able to detect cortical activation changes during long-term modulation of dopaminergic treatment in PD patients with wearing-off, and thus, this technique could be further investigated in advanced PD patients.
format	article
author	Nicola Tambasco Marco Muti Pietro Chiarini Roberto Tarducci Stefano Caproni Anna Castrioto Pasquale Nigro Lucilla Parnetti Pietro Floridi Aroldo Rossi Paolo Calabresi
author_facet	Nicola Tambasco Marco Muti Pietro Chiarini Roberto Tarducci Stefano Caproni Anna Castrioto Pasquale Nigro Lucilla Parnetti Pietro Floridi Aroldo Rossi Paolo Calabresi
author_sort	Nicola Tambasco
title	Entacapone reduces cortical activation in Parkinson's disease with wearing-off: a f-MRI study.
title_short	Entacapone reduces cortical activation in Parkinson's disease with wearing-off: a f-MRI study.
title_full	Entacapone reduces cortical activation in Parkinson's disease with wearing-off: a f-MRI study.
title_fullStr	Entacapone reduces cortical activation in Parkinson's disease with wearing-off: a f-MRI study.
title_full_unstemmed	Entacapone reduces cortical activation in Parkinson's disease with wearing-off: a f-MRI study.
title_sort	entacapone reduces cortical activation in parkinson's disease with wearing-off: a f-mri study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/af39b1d1cef64071ab39c349b1eb0fb5
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Entacapone reduces cortical activation in Parkinson's disease with wearing-off: a f-MRI study.

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