Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation

The mechanisms that regulate the activity of Ca2 +/calmodulin-dependent protein kinase II (CaMKII) in the context of heart failure are incompletely understood. Here the authors show that protein arginine methyltransferase 1 (PRMT1) prevents cardiac hyperactivation of CaMKII and heart failure develop...

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Autores principales:	Jung-Hoon Pyun, Hyun-Ji Kim, Myong-Ho Jeong, Byeong-Yun Ahn, Tuan Anh Vuong, Dong I. Lee, Seri Choi, Seung-Hoi Koo, Hana Cho, Jong-Sun Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af3a2e76bb0b4a2582ff80e76159a01c
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spelling	oai:doaj.org-article:af3a2e76bb0b4a2582ff80e76159a01c2021-12-02T14:38:50ZCardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation10.1038/s41467-018-07606-y2041-1723https://doaj.org/article/af3a2e76bb0b4a2582ff80e76159a01c2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07606-yhttps://doaj.org/toc/2041-1723The mechanisms that regulate the activity of Ca2 +/calmodulin-dependent protein kinase II (CaMKII) in the context of heart failure are incompletely understood. Here the authors show that protein arginine methyltransferase 1 (PRMT1) prevents cardiac hyperactivation of CaMKII and heart failure development by methylating CaMKII at arginine residues 9 and 275.Jung-Hoon PyunHyun-Ji KimMyong-Ho JeongByeong-Yun AhnTuan Anh VuongDong I. LeeSeri ChoiSeung-Hoi KooHana ChoJong-Sun KangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jung-Hoon Pyun Hyun-Ji Kim Myong-Ho Jeong Byeong-Yun Ahn Tuan Anh Vuong Dong I. Lee Seri Choi Seung-Hoi Koo Hana Cho Jong-Sun Kang Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
description	The mechanisms that regulate the activity of Ca2 +/calmodulin-dependent protein kinase II (CaMKII) in the context of heart failure are incompletely understood. Here the authors show that protein arginine methyltransferase 1 (PRMT1) prevents cardiac hyperactivation of CaMKII and heart failure development by methylating CaMKII at arginine residues 9 and 275.
format	article
author	Jung-Hoon Pyun Hyun-Ji Kim Myong-Ho Jeong Byeong-Yun Ahn Tuan Anh Vuong Dong I. Lee Seri Choi Seung-Hoi Koo Hana Cho Jong-Sun Kang
author_facet	Jung-Hoon Pyun Hyun-Ji Kim Myong-Ho Jeong Byeong-Yun Ahn Tuan Anh Vuong Dong I. Lee Seri Choi Seung-Hoi Koo Hana Cho Jong-Sun Kang
author_sort	Jung-Hoon Pyun
title	Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
title_short	Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
title_full	Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
title_fullStr	Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
title_full_unstemmed	Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
title_sort	cardiac specific prmt1 ablation causes heart failure through camkii dysregulation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/af3a2e76bb0b4a2582ff80e76159a01c
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Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation

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