Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

Therapies are needed for the prevention of chondrocyte hypertrophy and thinning of articular cartilage, features of osteoarthritic joint destruction. Here, the authors show that interfering with Sik3 signalling can increase the size of the chondrocyte population and reduce severity of a surgically i...

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Autores principales:	Yasuhito Yahara, Hiroshi Takemori, Minoru Okada, Azuma Kosai, Akihiro Yamashita, Tomohito Kobayashi, Kaori Fujita, Yumi Itoh, Masahiro Nakamura, Hiroyuki Fuchino, Nobuo Kawahara, Naoshi Fukui, Akira Watanabe, Tomoatsu Kimura, Noriyuki Tsumaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af3b32aa0cfb449abeb0966d62633a55
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spelling	oai:doaj.org-article:af3b32aa0cfb449abeb0966d62633a552021-12-02T14:39:34ZPterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik310.1038/ncomms109592041-1723https://doaj.org/article/af3b32aa0cfb449abeb0966d62633a552016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10959https://doaj.org/toc/2041-1723Therapies are needed for the prevention of chondrocyte hypertrophy and thinning of articular cartilage, features of osteoarthritic joint destruction. Here, the authors show that interfering with Sik3 signalling can increase the size of the chondrocyte population and reduce severity of a surgically induced mouse model of osteoarthritis.Yasuhito YaharaHiroshi TakemoriMinoru OkadaAzuma KosaiAkihiro YamashitaTomohito KobayashiKaori FujitaYumi ItohMasahiro NakamuraHiroyuki FuchinoNobuo KawaharaNaoshi FukuiAkira WatanabeTomoatsu KimuraNoriyuki TsumakiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yasuhito Yahara Hiroshi Takemori Minoru Okada Azuma Kosai Akihiro Yamashita Tomohito Kobayashi Kaori Fujita Yumi Itoh Masahiro Nakamura Hiroyuki Fuchino Nobuo Kawahara Naoshi Fukui Akira Watanabe Tomoatsu Kimura Noriyuki Tsumaki Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
description	Therapies are needed for the prevention of chondrocyte hypertrophy and thinning of articular cartilage, features of osteoarthritic joint destruction. Here, the authors show that interfering with Sik3 signalling can increase the size of the chondrocyte population and reduce severity of a surgically induced mouse model of osteoarthritis.
format	article
author	Yasuhito Yahara Hiroshi Takemori Minoru Okada Azuma Kosai Akihiro Yamashita Tomohito Kobayashi Kaori Fujita Yumi Itoh Masahiro Nakamura Hiroyuki Fuchino Nobuo Kawahara Naoshi Fukui Akira Watanabe Tomoatsu Kimura Noriyuki Tsumaki
author_facet	Yasuhito Yahara Hiroshi Takemori Minoru Okada Azuma Kosai Akihiro Yamashita Tomohito Kobayashi Kaori Fujita Yumi Itoh Masahiro Nakamura Hiroyuki Fuchino Nobuo Kawahara Naoshi Fukui Akira Watanabe Tomoatsu Kimura Noriyuki Tsumaki
author_sort	Yasuhito Yahara
title	Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
title_short	Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
title_full	Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
title_fullStr	Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
title_full_unstemmed	Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
title_sort	pterosin b prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting sik3
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/af3b32aa0cfb449abeb0966d62633a55
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Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

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