The controversies surrounding Giardia intestinalis assemblages A and B

Giardia intestinalis continues to be one of the most encountered parasitic diseases around the world. Although more frequently detected in developing countries, Giardia infections nonetheless pose significant public health problems in developed countries as well. Molecular characterisation of Giardi...

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Autores principales:	Patricia Zajaczkowski, Rogan Lee, Stephanie M. Fletcher-Lartey, Kate Alexander, Abela Mahimbo, Damien Stark, John T. Ellis
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Giardiasis Molecular biology Assemblages Zoonotic potential Typing Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/af3e2a634fec48f29c9be4de512a9735
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spelling	oai:doaj.org-article:af3e2a634fec48f29c9be4de512a97352021-11-12T04:49:55ZThe controversies surrounding Giardia intestinalis assemblages A and B2667-114X10.1016/j.crpvbd.2021.100055https://doaj.org/article/af3e2a634fec48f29c9be4de512a97352021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667114X21000492https://doaj.org/toc/2667-114XGiardia intestinalis continues to be one of the most encountered parasitic diseases around the world. Although more frequently detected in developing countries, Giardia infections nonetheless pose significant public health problems in developed countries as well. Molecular characterisation of Giardia isolates from humans and animals reveals that there are two genetically different assemblages (known as assemblage A and B) that cause human infections. However, the current molecular assays used to genotype G. intestinalis isolates are quite controversial. This is in part due to a complex phenomenon where assemblages are incorrectly typed and underreported depending on which targeted locus is sequenced. In this review, we outline current knowledge based on molecular epidemiological studies and raise questions as to the reliability of current genotyping assays and a lack of a globally accepted method. Additionally, we discuss the clinical symptoms caused by G. intestinalis infection and how these symptoms vary depending on the assemblage infecting an individual. We also introduce the host-parasite factors that play a role in the subsequent clinical presentation of an infected person, and explore which assemblages are most seen globally.Patricia ZajaczkowskiRogan LeeStephanie M. Fletcher-LarteyKate AlexanderAbela MahimboDamien StarkJohn T. EllisElsevierarticleGiardiasisMolecular biologyAssemblagesZoonotic potentialTypingInfectious and parasitic diseasesRC109-216ENCurrent Research in Parasitology and Vector-Borne Diseases, Vol 1, Iss , Pp 100055- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Giardiasis Molecular biology Assemblages Zoonotic potential Typing Infectious and parasitic diseases RC109-216
spellingShingle	Giardiasis Molecular biology Assemblages Zoonotic potential Typing Infectious and parasitic diseases RC109-216 Patricia Zajaczkowski Rogan Lee Stephanie M. Fletcher-Lartey Kate Alexander Abela Mahimbo Damien Stark John T. Ellis The controversies surrounding Giardia intestinalis assemblages A and B
description	Giardia intestinalis continues to be one of the most encountered parasitic diseases around the world. Although more frequently detected in developing countries, Giardia infections nonetheless pose significant public health problems in developed countries as well. Molecular characterisation of Giardia isolates from humans and animals reveals that there are two genetically different assemblages (known as assemblage A and B) that cause human infections. However, the current molecular assays used to genotype G. intestinalis isolates are quite controversial. This is in part due to a complex phenomenon where assemblages are incorrectly typed and underreported depending on which targeted locus is sequenced. In this review, we outline current knowledge based on molecular epidemiological studies and raise questions as to the reliability of current genotyping assays and a lack of a globally accepted method. Additionally, we discuss the clinical symptoms caused by G. intestinalis infection and how these symptoms vary depending on the assemblage infecting an individual. We also introduce the host-parasite factors that play a role in the subsequent clinical presentation of an infected person, and explore which assemblages are most seen globally.
format	article
author	Patricia Zajaczkowski Rogan Lee Stephanie M. Fletcher-Lartey Kate Alexander Abela Mahimbo Damien Stark John T. Ellis
author_facet	Patricia Zajaczkowski Rogan Lee Stephanie M. Fletcher-Lartey Kate Alexander Abela Mahimbo Damien Stark John T. Ellis
author_sort	Patricia Zajaczkowski
title	The controversies surrounding Giardia intestinalis assemblages A and B
title_short	The controversies surrounding Giardia intestinalis assemblages A and B
title_full	The controversies surrounding Giardia intestinalis assemblages A and B
title_fullStr	The controversies surrounding Giardia intestinalis assemblages A and B
title_full_unstemmed	The controversies surrounding Giardia intestinalis assemblages A and B
title_sort	controversies surrounding giardia intestinalis assemblages a and b
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/af3e2a634fec48f29c9be4de512a9735
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The controversies surrounding Giardia intestinalis assemblages A and B

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