Dopaminergic Modulation of Spectral and Spatial Characteristics of Parkinsonian Subthalamic Nucleus Beta Bursts

In Parkinson’s disease (PD), subthalamic nucleus (STN) beta burst activity is pathologically elevated. These bursts are reduced by dopamine and deep brain stimulation (DBS). Therefore, these bursts have been tested as a trigger for closed-loop DBS. To provide better targeted parameters for closed-lo...

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Autores principales:	Matthias Sure, Jan Vesper, Alfons Schnitzler, Esther Florin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	beta bursts directional leads local field potentials closed-loop DBS Parkinson’s disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/af3e8cb4c20945ee8716d67bb75d0d98
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spelling	oai:doaj.org-article:af3e8cb4c20945ee8716d67bb75d0d982021-11-11T05:39:37ZDopaminergic Modulation of Spectral and Spatial Characteristics of Parkinsonian Subthalamic Nucleus Beta Bursts1662-453X10.3389/fnins.2021.724334https://doaj.org/article/af3e8cb4c20945ee8716d67bb75d0d982021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.724334/fullhttps://doaj.org/toc/1662-453XIn Parkinson’s disease (PD), subthalamic nucleus (STN) beta burst activity is pathologically elevated. These bursts are reduced by dopamine and deep brain stimulation (DBS). Therefore, these bursts have been tested as a trigger for closed-loop DBS. To provide better targeted parameters for closed-loop stimulation, we investigate the spatial distribution of beta bursts within the STN and if they are specific to a beta sub-band. Local field potentials (LFP) were acquired in the STN of 27 PD patients while resting. Based on the orientation of segmented DBS electrodes, the LFPs were classified as anterior, postero-medial, and postero-lateral. Each recording lasted 30 min with (ON) and without (OFF) dopamine. Bursts were detected in three frequency bands: ±3 Hz around the individual beta peak frequency, low beta band (lBB), and high beta band (hBB). Medication reduced the duration and the number of bursts per minute but not the amplitude of the beta bursts. The burst amplitude was spatially modulated, while the burst duration and rate were frequency dependent. Furthermore, the hBB burst duration was positively correlated with the akinetic-rigid UPDRS III subscore. Overall, these findings on differential dopaminergic modulation of beta burst parameters suggest that hBB burst duration is a promising target for closed-loop stimulation and that burst parameters could guide DBS programming.Matthias SureJan VesperAlfons SchnitzlerAlfons SchnitzlerEsther FlorinFrontiers Media S.A.articlebeta burstsdirectional leadslocal field potentialsclosed-loop DBSParkinson’s diseaseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	beta bursts directional leads local field potentials closed-loop DBS Parkinson’s disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	beta bursts directional leads local field potentials closed-loop DBS Parkinson’s disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Matthias Sure Jan Vesper Alfons Schnitzler Alfons Schnitzler Esther Florin Dopaminergic Modulation of Spectral and Spatial Characteristics of Parkinsonian Subthalamic Nucleus Beta Bursts
description	In Parkinson’s disease (PD), subthalamic nucleus (STN) beta burst activity is pathologically elevated. These bursts are reduced by dopamine and deep brain stimulation (DBS). Therefore, these bursts have been tested as a trigger for closed-loop DBS. To provide better targeted parameters for closed-loop stimulation, we investigate the spatial distribution of beta bursts within the STN and if they are specific to a beta sub-band. Local field potentials (LFP) were acquired in the STN of 27 PD patients while resting. Based on the orientation of segmented DBS electrodes, the LFPs were classified as anterior, postero-medial, and postero-lateral. Each recording lasted 30 min with (ON) and without (OFF) dopamine. Bursts were detected in three frequency bands: ±3 Hz around the individual beta peak frequency, low beta band (lBB), and high beta band (hBB). Medication reduced the duration and the number of bursts per minute but not the amplitude of the beta bursts. The burst amplitude was spatially modulated, while the burst duration and rate were frequency dependent. Furthermore, the hBB burst duration was positively correlated with the akinetic-rigid UPDRS III subscore. Overall, these findings on differential dopaminergic modulation of beta burst parameters suggest that hBB burst duration is a promising target for closed-loop stimulation and that burst parameters could guide DBS programming.
format	article
author	Matthias Sure Jan Vesper Alfons Schnitzler Alfons Schnitzler Esther Florin
author_facet	Matthias Sure Jan Vesper Alfons Schnitzler Alfons Schnitzler Esther Florin
author_sort	Matthias Sure
title	Dopaminergic Modulation of Spectral and Spatial Characteristics of Parkinsonian Subthalamic Nucleus Beta Bursts
title_short	Dopaminergic Modulation of Spectral and Spatial Characteristics of Parkinsonian Subthalamic Nucleus Beta Bursts
title_full	Dopaminergic Modulation of Spectral and Spatial Characteristics of Parkinsonian Subthalamic Nucleus Beta Bursts
title_fullStr	Dopaminergic Modulation of Spectral and Spatial Characteristics of Parkinsonian Subthalamic Nucleus Beta Bursts
title_full_unstemmed	Dopaminergic Modulation of Spectral and Spatial Characteristics of Parkinsonian Subthalamic Nucleus Beta Bursts
title_sort	dopaminergic modulation of spectral and spatial characteristics of parkinsonian subthalamic nucleus beta bursts
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/af3e8cb4c20945ee8716d67bb75d0d98
work_keys_str_mv	AT matthiassure dopaminergicmodulationofspectralandspatialcharacteristicsofparkinsoniansubthalamicnucleusbetabursts AT janvesper dopaminergicmodulationofspectralandspatialcharacteristicsofparkinsoniansubthalamicnucleusbetabursts AT alfonsschnitzler dopaminergicmodulationofspectralandspatialcharacteristicsofparkinsoniansubthalamicnucleusbetabursts AT alfonsschnitzler dopaminergicmodulationofspectralandspatialcharacteristicsofparkinsoniansubthalamicnucleusbetabursts AT estherflorin dopaminergicmodulationofspectralandspatialcharacteristicsofparkinsoniansubthalamicnucleusbetabursts
_version_	1718439527721205760

Dopaminergic Modulation of Spectral and Spatial Characteristics of Parkinsonian Subthalamic Nucleus Beta Bursts

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