Association of Interleukin-10 Gene Polymorphisms with Ulcerative Colitis

This literature review is devoted to the study of the role of polymorphic variants of the anti-inflammatory interleukin-10 gene (Interleukin-10, IL10) in the etiology and pathogenesis of ulcerative colitis in patients of various ethnic groups.Aim. To generalize the results obtained from electronic d...

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Autores principales:	I. V. Zhilin, E. Yu. Chashkova, A. A. Zhilina, A. V. Markovskiy, A. D. Kim
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	il10 gene polymorphism ethnic groups ulcerative colitis inflammatory bowel diseases Science Q
Acceso en línea:	https://doaj.org/article/af415d6253fe43cea457c1d122dc854f
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spelling	oai:doaj.org-article:af415d6253fe43cea457c1d122dc854f2021-11-23T06:14:45ZAssociation of Interleukin-10 Gene Polymorphisms with Ulcerative Colitis2541-94202587-959610.29413/ABS.2020-5.6.7https://doaj.org/article/af415d6253fe43cea457c1d122dc854f2021-01-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2496https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596This literature review is devoted to the study of the role of polymorphic variants of the anti-inflammatory interleukin-10 gene (Interleukin-10, IL10) in the etiology and pathogenesis of ulcerative colitis in patients of various ethnic groups.Aim. To generalize the results obtained from electronic databases on the study of the characteristics of the course of ulcerative colitis in patients of different ethnic groups, taking into account the carriage of IL10 gene polymorphisms.Materials and methods. Twenty-five studies were selected, including four meta-analyzes devoted to the study of associative relationships of single nucleotide polymorphisms (SNPs) of the IL10 gene isolated from blood samples at positions -592AA/CA, -819CT, -1082АА/GA, and rs3024505 in the development and course of ulcerative colitis.Results. A number of researchers from Europe, Saudi Arabia report an increased incidence of ulcerative colitis among carriers of the IL10-1082AA SNP and a low incidence among carriers of -592AA. Positive associations of IL10-819CT with the prevalence of ulcerative colitis are presented in single reports from Europe, the Middle East and in a number of studies from Asian countries. However, the identified associations, even within the same population, are often contradictory. Perhaps the discrepancies are due to the ethnic heterogeneity of the groups in the considered cohorts, and therefore it is necessary to continue epidemiological studies with a large sample size in specific geographic areas.I. V. ZhilinE. Yu. ChashkovaA. A. ZhilinaA. V. MarkovskiyA. D. KimScientific Сentre for Family Health and Human Reproduction Problemsarticleil10 gene polymorphismethnic groupsulcerative colitisinflammatory bowel diseasesScienceQRUActa Biomedica Scientifica, Vol 5, Iss 6, Pp 58-65 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	il10 gene polymorphism ethnic groups ulcerative colitis inflammatory bowel diseases Science Q
spellingShingle	il10 gene polymorphism ethnic groups ulcerative colitis inflammatory bowel diseases Science Q I. V. Zhilin E. Yu. Chashkova A. A. Zhilina A. V. Markovskiy A. D. Kim Association of Interleukin-10 Gene Polymorphisms with Ulcerative Colitis
description	This literature review is devoted to the study of the role of polymorphic variants of the anti-inflammatory interleukin-10 gene (Interleukin-10, IL10) in the etiology and pathogenesis of ulcerative colitis in patients of various ethnic groups.Aim. To generalize the results obtained from electronic databases on the study of the characteristics of the course of ulcerative colitis in patients of different ethnic groups, taking into account the carriage of IL10 gene polymorphisms.Materials and methods. Twenty-five studies were selected, including four meta-analyzes devoted to the study of associative relationships of single nucleotide polymorphisms (SNPs) of the IL10 gene isolated from blood samples at positions -592AA/CA, -819CT, -1082АА/GA, and rs3024505 in the development and course of ulcerative colitis.Results. A number of researchers from Europe, Saudi Arabia report an increased incidence of ulcerative colitis among carriers of the IL10-1082AA SNP and a low incidence among carriers of -592AA. Positive associations of IL10-819CT with the prevalence of ulcerative colitis are presented in single reports from Europe, the Middle East and in a number of studies from Asian countries. However, the identified associations, even within the same population, are often contradictory. Perhaps the discrepancies are due to the ethnic heterogeneity of the groups in the considered cohorts, and therefore it is necessary to continue epidemiological studies with a large sample size in specific geographic areas.
format	article
author	I. V. Zhilin E. Yu. Chashkova A. A. Zhilina A. V. Markovskiy A. D. Kim
author_facet	I. V. Zhilin E. Yu. Chashkova A. A. Zhilina A. V. Markovskiy A. D. Kim
author_sort	I. V. Zhilin
title	Association of Interleukin-10 Gene Polymorphisms with Ulcerative Colitis
title_short	Association of Interleukin-10 Gene Polymorphisms with Ulcerative Colitis
title_full	Association of Interleukin-10 Gene Polymorphisms with Ulcerative Colitis
title_fullStr	Association of Interleukin-10 Gene Polymorphisms with Ulcerative Colitis
title_full_unstemmed	Association of Interleukin-10 Gene Polymorphisms with Ulcerative Colitis
title_sort	association of interleukin-10 gene polymorphisms with ulcerative colitis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/af415d6253fe43cea457c1d122dc854f
work_keys_str_mv	AT ivzhilin associationofinterleukin10genepolymorphismswithulcerativecolitis AT eyuchashkova associationofinterleukin10genepolymorphismswithulcerativecolitis AT aazhilina associationofinterleukin10genepolymorphismswithulcerativecolitis AT avmarkovskiy associationofinterleukin10genepolymorphismswithulcerativecolitis AT adkim associationofinterleukin10genepolymorphismswithulcerativecolitis
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Association of Interleukin-10 Gene Polymorphisms with Ulcerative Colitis

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