Ambient particulate air pollution (PM2.5) is associated with the ratio of type 2 diabetes to obesity

Abstract We used county level data for T2D prevalence across the mainland USA and matched this to county level ambient PM2.5. Multiple linear regression was used to determine the relation between prevalence of T2D with PM2.5 after adjustment for confounding factors. PM2.5 explained 6.3% of the spati...

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Autores principales:	Mohsen Mazidi, John R. Speakman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/af41d6f071dd42348ac0a32d3e104d17
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spelling	oai:doaj.org-article:af41d6f071dd42348ac0a32d3e104d172021-12-02T12:32:57ZAmbient particulate air pollution (PM2.5) is associated with the ratio of type 2 diabetes to obesity10.1038/s41598-017-08287-12045-2322https://doaj.org/article/af41d6f071dd42348ac0a32d3e104d172017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08287-1https://doaj.org/toc/2045-2322Abstract We used county level data for T2D prevalence across the mainland USA and matched this to county level ambient PM2.5. Multiple linear regression was used to determine the relation between prevalence of T2D with PM2.5 after adjustment for confounding factors. PM2.5 explained 6.3% of the spatial variation in obesity, and 17.9% of the spatial variation in T2D. After correcting the T2D prevalence for obesity, race, poverty, education and temperature, PM2.5 still explained 8.3% of the residual variation in males (P < 0.0001) and 11.5% in females (P < 0.0001). The effect on obesity prevalence corrected for poverty, race education and temperature was much lower and hence the ratio of T2D to obesity prevalence was significantly associated with PM2.5 in males (R2 = 11.1%, P < 0.0001) and females (R2 = 16.8%, P < 0.0001). This association was repeated across non-African countries (R2 = 14.9%, P < 0.0001). High levels of PM2.5 probably contribute to increased T2D prevalence in the USA, but have a more minor effect on the obesity. Exposure to high environmental levels of PM2.5 (relative to the USA) may explain the disproportional risk of T2D in relation to obesity in Asian populations.Mohsen MazidiJohn R. SpeakmanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohsen Mazidi John R. Speakman Ambient particulate air pollution (PM2.5) is associated with the ratio of type 2 diabetes to obesity
description	Abstract We used county level data for T2D prevalence across the mainland USA and matched this to county level ambient PM2.5. Multiple linear regression was used to determine the relation between prevalence of T2D with PM2.5 after adjustment for confounding factors. PM2.5 explained 6.3% of the spatial variation in obesity, and 17.9% of the spatial variation in T2D. After correcting the T2D prevalence for obesity, race, poverty, education and temperature, PM2.5 still explained 8.3% of the residual variation in males (P < 0.0001) and 11.5% in females (P < 0.0001). The effect on obesity prevalence corrected for poverty, race education and temperature was much lower and hence the ratio of T2D to obesity prevalence was significantly associated with PM2.5 in males (R2 = 11.1%, P < 0.0001) and females (R2 = 16.8%, P < 0.0001). This association was repeated across non-African countries (R2 = 14.9%, P < 0.0001). High levels of PM2.5 probably contribute to increased T2D prevalence in the USA, but have a more minor effect on the obesity. Exposure to high environmental levels of PM2.5 (relative to the USA) may explain the disproportional risk of T2D in relation to obesity in Asian populations.
format	article
author	Mohsen Mazidi John R. Speakman
author_facet	Mohsen Mazidi John R. Speakman
author_sort	Mohsen Mazidi
title	Ambient particulate air pollution (PM2.5) is associated with the ratio of type 2 diabetes to obesity
title_short	Ambient particulate air pollution (PM2.5) is associated with the ratio of type 2 diabetes to obesity
title_full	Ambient particulate air pollution (PM2.5) is associated with the ratio of type 2 diabetes to obesity
title_fullStr	Ambient particulate air pollution (PM2.5) is associated with the ratio of type 2 diabetes to obesity
title_full_unstemmed	Ambient particulate air pollution (PM2.5) is associated with the ratio of type 2 diabetes to obesity
title_sort	ambient particulate air pollution (pm2.5) is associated with the ratio of type 2 diabetes to obesity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/af41d6f071dd42348ac0a32d3e104d17
work_keys_str_mv	AT mohsenmazidi ambientparticulateairpollutionpm25isassociatedwiththeratiooftype2diabetestoobesity AT johnrspeakman ambientparticulateairpollutionpm25isassociatedwiththeratiooftype2diabetestoobesity
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Ambient particulate air pollution (PM2.5) is associated with the ratio of type 2 diabetes to obesity

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